Abstract：
:Paclitaxel drug coated balloons (DCBs) should provide optimal drug transfer exclusively to the target tissue. The aim of this study was to evaluate the particle loss by handling during angioplasty. A robotic arm was developed for systematic and reproducible drug abrasion experiments. The contact force on eight different commercially available DCB types was gradually increased, and high-resolution microscopic images of the deflated and inflated balloons were recorded. Three types of DCBs were classified: no abrasion of the drug in both statuses (deflated and inflated), significant abrasion only in the inflated status, and significant abrasion in both statuses. Quantitative measurements via image processing confirmed the qualitative classification and showed changes of the drug area between 2.25 and 45.73% (13.28 ± 14.29%) in the deflated status, and between 1.66 and 40.41% (21.43 ± 16.48%) in the inflated status. The structures and compositions of the DCBs are different, some are significantly more susceptible to drug loss. Particle loss by handling during angioplasty leads to different paclitaxel doses in the target regions for same DCB types. Susceptibility to involuntary drug loss may cause side effects, such as varying effective paclitaxel doses, which may explain variations in studies regarding the therapeutic outcome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Heinrich A,Engler MS,Güttler FV,Matthäus C,Popp J,Teichgräber UKdoi
10.1038/s41598-020-74227-1subject
Has Abstractpub_date
2020-10-14 00:00:00pages
17220issue
1issn
2045-2322pii
10.1038/s41598-020-74227-1journal_volume
10pub_type
杂志文章abstract：:An industrial waste, 1,2,3-trichloropropane (TCP), is toxic and extremely recalcitrant to biodegradation. To date, no natural TCP degraders able to mineralize TCP aerobically have been isolated. In this work, we engineered a biosafety Pseudomonas putida strain KT2440 for aerobic mineralization of TCP by implantation o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07435-x
更新日期：2017-08-01 00:00:00
abstract：:During interpersonal interactions, people perform actions with different forms of vitality, communicating their positive or negative attitude toward others. For example, a handshake can be "soft" or "vigorous", a caress can be 'kind' or 'rushed'. While previous studies have shown that the dorso-central insula is a key...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73728-3
更新日期：2020-10-09 00:00:00
abstract：:Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells. However, the role of CEP55 in pancreatic cancer (PANC) remains unclear. Herein, upregulated expression of CEP55 (associa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06132-z
更新日期：2017-07-19 00:00:00
abstract：:Surface defect of nanomaterials is an important physical parameter which significantly influences their physical and chemical performances. In this work, high concentration of surface oxygen vancancies (SOVs) are successfully introduced on {001} facets exposed BiOBr nanosheets via a simple surface modification using p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24918
更新日期：2016-04-26 00:00:00
abstract：:Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late December 2013. This event demonstrated the rapid establishment of extreme Antarctic sea ice conditions on synoptic time scales. The event was a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05317
更新日期：2014-06-17 00:00:00
abstract：:Somatic embryogenesis receptor kinases (SERKs) belong to a small gene family of receptor-like kinases involved in signal transduction. A total of 54 genes were shortlisted from the wheat genome survey sequence of which 5 were classified as SERKs and 49 were identified as SERK-like (SERLs). Tissue- specific expression ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10038-1
更新日期：2017-09-28 00:00:00
abstract：:The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15005
更新日期：2015-10-07 00:00:00
abstract：:Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66509-5
更新日期：2020-06-12 00:00:00
abstract：:α-Ketoglutarate (αKG) is a metabolite of the tricarboxylic acid cycle, important for biomass synthesis and a precursor for biotechnological products like 1,4-butanediol. In the eukaryote Saccharomyces cerevisiae αKG is present in different compartments. Compartmentation and (intra-)cellular transport could interfere w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69178-6
更新日期：2020-07-30 00:00:00
abstract：:Understanding the role of morphogen in activating its target genes, otherwise epigenetically repressed, during change in cell fate specification is a very fascinating yet relatively unexplored domain. Our in vivo loss-of-function genetic analyses reveal that specifically during ectopic eye formation, the morphogen Dec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27270
更新日期：2016-06-07 00:00:00
abstract：:Huntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05224-0
更新日期：2017-07-12 00:00:00
abstract：:Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22460
更新日期：2016-03-03 00:00:00
abstract：:Carbonic acid (H2CO3) forms in small amounts when CO2 dissolves in H2O, yet decomposes rapidly under ambient conditions of temperature and pressure. Despite its fleeting existence, H2CO3 plays an important role in the global carbon cycle and in biological carbonate-containing systems. The short lifetime in water and p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19902
更新日期：2016-01-27 00:00:00
abstract：:Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21365
更新日期：2016-02-25 00:00:00
abstract：:A great deal of attention has been recently focused on Electrochromic (EC) materials and EC based devices, promoting mainly applications related to display technology. In this case, EC based displays are usually actuated by the application of low dc bias voltages, changing their appearance from transparent to opaque. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28839
更新日期：2016-06-30 00:00:00
abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42683
更新日期：2017-02-20 00:00:00
abstract：:Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of pheromones in the crop plants. This has now been achieved by genetically engineering a hexaploid variety of wheat to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11183
更新日期：2015-06-25 00:00:00
abstract：:The recent combination of ultra-intense lasers and laser-accelerated electron beams is enabling the development of a new generation of compact x-ray light sources, the coherence of which depends directly on electron beam emittance. Although the emittance of accelerated electron beams can be low, it can grow due to the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24622
更新日期：2016-04-19 00:00:00
abstract：:In this study, novel ZnS@In2S3 core@shell hollow nanospheres were fabricated by a facile refluxing method for the first time, and the formation mechanism of hollow structure with interior architecture was discussed based on ion-exchange Ostwald ripening. As the photocatalytic material for degradation of gaseous o-Dich...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16732-4
更新日期：2017-11-27 00:00:00
abstract：:People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51383-7
更新日期：2019-10-14 00:00:00
abstract：:The risk of Helicobacter pylori infection is highest in childhood, but the colonization process of the stomach mucosa is poorly understood. We used anesthetized Mongolian gerbils to study the initial stages of H. pylori colonization. Prandial and postprandial gastric conditions characteristic of humans of different ag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00994
更新日期：2012-01-01 00:00:00
abstract：:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25461-1
更新日期：2018-05-08 00:00:00
abstract：:Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05816
更新日期：2014-07-24 00:00:00
abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11205
更新日期：2015-07-02 00:00:00
abstract：:Traditional radiomics models mainly rely on explicitly-designed handcrafted features from medical images. This paper aimed to investigate if deep features extracted via transfer learning can generate radiomics signatures for prediction of overall survival (OS) in patients with Glioblastoma Multiforme (GBM). This study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10649-8
更新日期：2017-09-04 00:00:00
abstract：:Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28137-y
更新日期：2018-06-27 00:00:00
abstract：:WRINKLED1 (WRI1), an APETALA2 (AP2)-type transcription factor, has been shown to be required for the regulation of carbon partitioning into fatty acid (FA) synthesis in plant seeds. To our knowledge, the regulatory network of WRI1 remains unknown in Prunus sibirica kernel (PSK), a novel woody biodiesel feedstock in Ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39236-9
更新日期：2019-02-25 00:00:00
abstract：:Oceanic physics at fine scale; e.g. eddies, fronts, filaments; are notoriously difficult to sample. However, an increasing number of theoretical approaches hypothesize that these processes affect phytoplankton diversity which have cascading effects on regional ecosystems. In 2015, we targeted the Iroise Sea (France) a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82071-0
更新日期：2021-01-29 00:00:00
abstract：:To investigate the potential role of vitamin D (1,25(OH)2D3) in preventing the development of nasal polyps, we examined the effect of vitamin D on myofibroblast differentiation and extracellular matrix (ECM) production in TGF-β1-induced nasal polyp-derived fibroblasts (NPDFs) and elucidated the mechanisms underlying i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07561-6
更新日期：2017-08-04 00:00:00
abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27633
更新日期：2016-06-08 00:00:00
