Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome.

abstract：:The spatial distributions of diverse facilities are often understood in terms of the optimization of the commute distance or the economic profit. Incorporating more general objective functions into such optimization framework may be useful, helping the policy decisions to meet various social and economic demands. As a...

journal_title：Scientific reports

authors： Lee MJ,Kim K,Son J,Lee DS

更新日期：2020-05-25 00:00:00

abstract：:It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects. First, we...

journal_title：Scientific reports

authors： Kimura T,Obata A,Shimoda M,Shimizu I,da Silva Xavier G,Okauchi S,Hirukawa H,Kohara K,Mune T,Moriuchi S,Hiraoka A,Tamura K,Chikazawa G,Ishida A,Yoshitaka H,Rutter GA,Kaku K,Kaneto H

更新日期：2018-07-13 00:00:00

abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

journal_title：Scientific reports

authors： Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

更新日期：2018-06-11 00:00:00

abstract：:Many deltas are likely undergoing net erosion because of rapid decreases in riverine sediment supply and rising global sea levels. However, detecting erosion in subaqueous deltas is usually difficult because of the lack of bathymetric data. In this study, by comparing bathymetric data between 1981 and 2012 and surfici...

journal_title：Scientific reports

authors： Luo XX,Yang SL,Wang RS,Zhang CY,Li P

更新日期：2017-02-01 00:00:00

abstract：:We aimed to establish a high-performing and robust classification strategy, using magnetic resonance imaging (MRI), along with combinations of feature extraction and selection in human and machine learning using radiomics or deep features by employing a small dataset. Using diffusion and contrast-enhanced T1-weighted ...

journal_title：Scientific reports

authors： Yun J,Park JE,Lee H,Ham S,Kim N,Kim HS

更新日期：2019-04-05 00:00:00

abstract：:This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and...

journal_title：Scientific reports

authors： Povedano E,Vargas E,Montiel VR,Torrente-Rodríguez RM,Pedrero M,Barderas R,Segundo-Acosta PS,Peláez-García A,Mendiola M,Hardisson D,Campuzano S,Pingarrón JM

更新日期：2018-04-23 00:00:00

abstract：:Mortuary practices in human evolution record cognitive, social changes and technological innovations. The Neolithic Revolution in the Levant was a watershed in this domain that has long fascinated the archaeological community. Plaster modelled skulls are well known at Jericho and several other Neolithic sites, and in ...

journal_title：Scientific reports

authors： Solazzo C,Courel B,Connan J,van Dongen BE,Barden H,Penkman K,Taylor S,Demarchi B,Adam P,Schaeffer P,Nissenbaum A,Bar-Yosef O,Buckley M

更新日期：2016-08-09 00:00:00

abstract：:Hereditary tyrosinemia type 1 (HT1) is a severe inborn error of metabolism, impacting the tyrosine catabolic pathway with a high incidence of hepatocellular carcinoma (HCC). Using a HT1 murine model, we investigated the changes in profiles of circulating and hepatic miRNAs. The aim was to determine if plasma miRNAs co...

journal_title：Scientific reports

authors： Angileri F,Morrow G,Scoazec JY,Gadot N,Roy V,Huang S,Wu T,Tanguay RM

更新日期：2016-06-10 00:00:00

abstract：:Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often expensive due to the excessive consumption of reagents. Microfluidics...

journal_title：Scientific reports

authors： Khot MI,Levenstein MA,de Boer GN,Armstrong G,Maisey T,Svavarsdottir HS,Andrew H,Perry SL,Kapur N,Jayne DG

更新日期：2020-09-28 00:00:00

abstract：:The hippocampus has a significant association with memory, cognition and emotions. The dopaminergic projections from both the ventral tegmental area and substantia nigra are thought to be involved in hippocampal activity. To date, however, few studies have investigated dopaminergic innervation in the hippocampus or th...

journal_title：Scientific reports

authors： Castro-Hernández J,Adlard PA,Finkelstein DI

更新日期：2017-03-14 00:00:00

abstract：:GSK3α has been identified as a new target in the treatment of acute myeloid leukemia (AML). However, most GSK3 inhibitors lack specificity for GSK3α over GSK3β and other kinases. We have previously shown in lung cancer cells that GSK3α and to a lesser extent GSK3β are inhibited by the advanced clinical candidate tivan...

journal_title：Scientific reports

authors： Kuenzi BM,Remsing Rix LL,Kinose F,Kroeger JL,Lancet JE,Padron E,Rix U

更新日期：2019-01-24 00:00:00

abstract：:The outstanding optoelectronics and photovoltaic properties of metal halide perovskites, including high carrier motilities, low carrier recombination rates, and the tunable spectral absorption range are attributed to the unique electronic properties of these materials. While DFT provides reliable structures and stabil...

journal_title：Scientific reports

authors： Tao SX,Cao X,Bobbert PA

更新日期：2017-10-30 00:00:00

abstract：:A crystal of emerging magnetic charges is expected in the phase diagram of the dipolar kagomé spin ice. An observation of charge crystallites in thermally demagnetized artificial spin ice arrays has been recently reported by S. Zhang and coworkers and explained through the thermodynamics of the system as it approaches...

journal_title：Scientific reports

authors： Montaigne F,Lacour D,Chioar IA,Rougemaille N,Louis D,Mc Murtry S,Riahi H,Burgos BS,Menteş TO,Locatelli A,Canals B,Hehn M

更新日期：2014-07-16 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...

journal_title：Scientific reports

authors： Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

更新日期：2018-02-13 00:00:00

abstract：:Spreading rumors on the Internet has become increasingly pervasive due to the proliferation of online social media. This paper investigates how rumors are amplified by a group of users who share similar interests or views, dubbed as an echo chamber. To this end, we identify and analyze 'rumor' echo chambers, each of w...

journal_title：Scientific reports

authors： Choi D,Chun S,Oh H,Han J,Kwon TT

更新日期：2020-01-15 00:00:00

abstract：:Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfolded CWD prion protein (PrP(CWD)) by western blotting, ELISA, or immunohistochemistry (IHC). These techniques require separate sample collections (frozen and fixed) which may result in discrepancies due to variation in ...

journal_title：Scientific reports

authors： Hoover CE,Davenport KA,Henderson DM,Pulscher LA,Mathiason CK,Zabel MD,Hoover EA

更新日期：2016-05-09 00:00:00

abstract：:The present study investigated the effect of acute stress on attentional bias to threat using behavioral and ERP methods. Sixty-two male participants were randomly assigned to a stress condition (Trier Social Stress Test) or a control condition. To examine the impact of stress-induced cortisol on attentional bias to t...

journal_title：Scientific reports

authors： Jiang C,Buchanan TW,Yao Z,Zhang K,Wu J,Zhang L

更新日期：2017-11-06 00:00:00

abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...

journal_title：Scientific reports

authors： Walker R,Poleszczuk J,Pilon-Thomas S,Kim S,Anderson AARA,Czerniecki BJ,Harrison LB,Moros EG,Enderling H

更新日期：2018-06-21 00:00:00

abstract：:Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants pe...

journal_title：Scientific reports

authors： Lee SH,Huh KH,Joo DJ,Kim MS,Kim SI,Lee J,Park MS,Kim YS,Kim SK,Chang J,Kim YS,Kim SY

更新日期：2017-05-08 00:00:00

abstract：:We propose efficient schemes of direct concurrence measurement for two-qubit spin and photon-polarization entangled states via the interaction between single-photon pulses and nitrogen-vacancy (NV) centers in diamond embedded in optical microcavities. For different entangled-state types, diversified quantum devices an...

journal_title：Scientific reports

authors： Cheng LY,Yang GH,Guo Q,Wang HF,Zhang S

更新日期：2016-01-18 00:00:00

abstract：:Use of human induced pluripotent stem cells (h-iPSCs) for bone tissue engineering is most appealing, because h-iPSCs are an inexhaustible source of osteocompetent cells. The present study investigated the contribution of undifferentiated h-iPSCs and elucidated aspects of the underlying mechanism(s) of the involvement ...

journal_title：Scientific reports

authors： Oudina K,Paquet J,Moya A,Massourides E,Bensidhoum M,Larochette N,Deschepper M,Pinset C,Petite H

更新日期：2018-11-20 00:00:00

abstract：:Wood density (WD) relates to important tree functions such as stem mechanics and resistance against pathogens. This functional trait can exhibit high intraindividual variability both radially and vertically. With the rise of LiDAR-based methodologies allowing nondestructive tree volume estimations, failing to account ...

journal_title：Scientific reports

authors： Momo ST,Ploton P,Martin-Ducup O,Lehnebach R,Fortunel C,Sagang LBT,Boyemba F,Couteron P,Fayolle A,Libalah M,Loumeto J,Medjibe V,Ngomanda A,Obiang D,Pélissier R,Rossi V,Yongo O,PREREDD Collaborators.,Sonké B,Barbier N

更新日期：2020-02-06 00:00:00

abstract：:Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...

journal_title：Scientific reports

authors： Koh HM,Jang BG,Kim DC

更新日期：2020-08-24 00:00:00

abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...

journal_title：Scientific reports

authors： Dragset MS,Ioerger TR,Zhang YJ,Mærk M,Ginbot Z,Sacchettini JC,Flo TH,Rubin EJ,Steigedal M

更新日期：2019-08-06 00:00:00

abstract：:Coral reefs all over the Indo-Pacific suffer from substantial damage caused by the crown-of-thorns seastar Acanthaster planci, a voracious predator that moves on and between reefs to seek out its coral prey. Chemoreception is thought to guide A. planci. As vision was recently introduced as another sense involved in se...

journal_title：Scientific reports

authors： Sigl R,Steibl S,Laforsch C

更新日期：2016-08-01 00:00:00

abstract：:In southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for th...

journal_title：Scientific reports

authors： Zhang H,Cheng H,Spötl C,Cai Y,Sinha A,Tan L,Yi L,Yan H,Kathayat G,Ning Y,Li X,Zhang F,Zhao J,Edwards RL

更新日期：2018-08-17 00:00:00

abstract：:The pulsed events of rainstorm erosion on the Loess Plateau are well-known, but little information is available concerning the characteristics of superficial soil erosion processes caused by heavy rainstorms at the watershed scale. This study statistically evaluated characteristics of pulsed runoff-erosion events base...

journal_title：Scientific reports

authors： Wu L,Jiang J,Li GX,Ma XY

更新日期：2018-02-27 00:00:00

abstract：:Today's high-power laser systems are capable of reaching photon intensities up to 1022 W cm-2, generating plasmas when interacting with material. The high intensity and ultrashort laser pulse duration (fs) make direct observation of plasma dynamics a challenging task. In the field of laser-plasma physics and especiall...

journal_title：Scientific reports

authors： Haffa D,Bin J,Speicher M,Allinger K,Hartmann J,Kreuzer C,Ridente E,Ostermayr TM,Schreiber J

更新日期：2019-05-22 00:00:00

abstract：:Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we s...

journal_title：Scientific reports

authors： Guo QS,Song Y,Hua KQ,Gao SJ

更新日期：2017-05-18 00:00:00

abstract：:Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...

journal_title：Scientific reports

authors： Pelz PM,Qiu WX,Bücker R,Kassier G,Miller RJD

更新日期：2017-08-29 00:00:00