Risk factors for Pneumocystis jirovecii pneumonia (PJP) in kidney transplantation recipients.

abstract：:Muscular dystrophy-dystroglycanopathies comprise a heterogeneous and complex group of disorders caused by loss-of-function mutations in a multitude of genes that disrupt the glycobiology of α-dystroglycan, thereby affecting its ability to function as a receptor for extracellular matrix proteins. Of the various genes i...

journal_title：Scientific reports

authors： Vannoy CH,Leroy V,Broniowska K,Lu QL

更新日期：2019-07-11 00:00:00

abstract：:Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved in regulating mitochondrial functions under physiological conditions. However, whether mtCB1R affords neuroprotection aga...

journal_title：Scientific reports

authors： Ma L,Jia J,Niu W,Jiang T,Zhai Q,Yang L,Bai F,Wang Q,Xiong L

更新日期：2015-07-28 00:00:00

abstract：:Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...

journal_title：Scientific reports

authors： Yuan S,Yin S,Liu M,Kong JQ

更新日期：2018-04-12 00:00:00

abstract：:Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase. Here we adapted th...

journal_title：Scientific reports

authors： Siegmund V,Piater B,Zakeri B,Eichhorn T,Fischer F,Deutsch C,Becker S,Toleikis L,Hock B,Betz UA,Kolmar H

更新日期：2016-12-16 00:00:00

abstract：:β-Lactamases are a major threat to the clinical use of carbapenems, which are often antibiotics of last resort. Despite this, the reaction outcomes and mechanisms by which β-lactamases degrade carbapenems are still not fully understood. The carbapenem bicyclic core consists of a β-lactam ring fused to a pyrroline ring...

journal_title：Scientific reports

authors： Lohans CT,Freeman EI,Groesen EV,Tooke CL,Hinchliffe P,Spencer J,Brem J,Schofield CJ

更新日期：2019-09-20 00:00:00

abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

journal_title：Scientific reports

authors： Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

更新日期：2016-02-10 00:00:00

abstract：:Conventional effluent trading systems (ETSs) between point sources (PSs) and nonpoint sources (NPSs) are often unreliable because of the uncertain characteristics of NPSs. In this study, a new framework was established for PS-NPS ETSs, and a comprehensive analysis was conducted by quantifying the impacts of the uncert...

journal_title：Scientific reports

authors： Chen L,Han Z,Wang G,Shen Z

更新日期：2016-07-11 00:00:00

abstract：:On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...

journal_title：Scientific reports

authors： Judd CJ,Haddow SL,Champness NR,Saywell A

更新日期：2017-11-06 00:00:00

abstract：:Dibutyl phthalate (DBP) is well known as a high-priority pollutant. This study explored the impacts of DBP on the metabolic pathways of microbes in black soils in the short term (20 days). The results showed that the microbial communities were changed in black soils with DBP. In nitrogen cycling, the abundances of the...

journal_title：Scientific reports

authors： Xu W,You Y,Wang Z,Chen W,Zeng J,Zhao X,Su Y

更新日期：2018-02-08 00:00:00

abstract：:BST-2/tetherin is an interferon-inducible antiviral protein that blocks the release of various enveloped viruses, including HIV-1. Hepatitis B virus (HBV), a major cause of liver disease, belongs to the Hepadnaviridae family of enveloped DNA viruses. Whether BST-2 regulates HBV production is largely unknown. In this r...

journal_title：Scientific reports

authors： Lv M,Zhang B,Shi Y,Han Z,Zhang Y,Zhou Y,Zhang W,Niu J,Yu XF

更新日期：2015-06-29 00:00:00

abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...

journal_title：Scientific reports

authors： Luo Y,Qu T,Cui Y,Pan Y,Yu M,Luo H,Jia Y,Tan Z,Liu J,Zhang B

更新日期：2019-07-01 00:00:00

abstract：:We formulate uncertainty relations for arbitrary N observables. Two uncertainty inequalities are presented in terms of the sum of variances and standard deviations, respectively. The lower bounds of the corresponding sum uncertainty relations are explicitly derived. These bounds are shown to be tighter than the ones s...

journal_title：Scientific reports

authors： Chen B,Fei SM

更新日期：2015-09-15 00:00:00

abstract：:Glutamate (Glu), the key excitatory neurotransmitter in the central nervous system, is considered essential for brain functioning and has a vital role in learning and memory formation. Earlier it was considered as a harmful agent but later found to be useful for many body functions. However, studies regarding the effe...

journal_title：Scientific reports

authors： Tabassum S,Ahmad S,Madiha S,Shahzad S,Batool Z,Sadir S,Haider S

更新日期：2020-07-08 00:00:00

abstract：:Root-knot nematodes (RKNs) are obligate biotrophic parasites that invade plant roots and engage in prolonged and intimate relationships with their hosts. Nematode secretions, some of which have immunosuppressing activity, play essential roles in successful parasitism; however, their mechanisms of action remain largely...

journal_title：Scientific reports

authors： Niu J,Liu P,Liu Q,Chen C,Guo Q,Yin J,Yang G,Jian H

更新日期：2016-01-22 00:00:00

abstract：:Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...

journal_title：Scientific reports

authors： Jin L,Sun S,Ryu Y,Piao ZH,Liu B,Choi SY,Kim GR,Kim HS,Kee HJ,Jeong MH

更新日期：2018-06-18 00:00:00

abstract：:This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...

journal_title：Scientific reports

authors： Shi YX,Yin JY,Shen Y,Zhang W,Zhou HH,Liu ZQ

更新日期：2017-08-14 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:Prenatal ethanol exposure (PEE) is an established risk factor for intrauterine growth retardation. The present study was designed to determine whether PEE can increase the susceptibility of high-fat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear mo...

journal_title：Scientific reports

authors： He Z,Li J,Luo H,Zhang L,Ma L,Chen L,Wang H

更新日期：2015-12-03 00:00:00

abstract：:The structural characterization correlated to the processing control of hierarchical structure of planar heterojunction perovskite layer is still incomplete due to the limitations of conventional microscopy and X-ray diffraction. This present study performed the simultaneously grazing-incidence small-angle scattering ...

journal_title：Scientific reports

authors： Huang YC,Tsao CS,Cho YJ,Chen KC,Chiang KM,Hsiao SY,Chen CW,Su CJ,Jeng US,Lin HW

更新日期：2015-09-04 00:00:00

abstract：:SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD(+)-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, w...

journal_title：Scientific reports

authors： Hu A,Huang JJ,Li RL,Lu ZY,Duan JL,Xu WH,Chen XP,Fan JP

更新日期：2015-08-24 00:00:00

abstract：:Dementia is a major public health issue worldwide and chronic use of benzodiazepine, which is very frequent in northern countries, was found to be a risk factor of dementia. This work aims at evaluating the impact of a reduction in chronic use of benzodiazepine on the future burden of dementia in France. Using estimat...

journal_title：Scientific reports

authors： Jacqmin-Gadda H,Guillet F,Mathieu C,Helmer C,Pariente A,Joly P

更新日期：2020-09-04 00:00:00

abstract：:Pinellia (Pinellia ternata (Thunb.) Breit.), as important medicinal plant, has been used to treat various ailments for a long time. The sixteen ploid plant (2n = 16 * 13 = 208) Pinellia T2Plus line was obtained from an octoploid (2n = 8 * 13 = 104) T2 line by chromosome-doubling technique. Compared with T2 line, the c...

journal_title：Scientific reports

authors： Lu J,Liu JN,Sarsaiya S,Duns GJ,Han J,Jin L,Chen J

更新日期：2020-03-12 00:00:00

abstract：:Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...

journal_title：Scientific reports

authors： Gu B,Chang J,Min Y,Ge Y,Zhu Q,Galloway JN,Peng C

更新日期：2013-01-01 00:00:00

abstract：:Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosis and portal hypertension and in experimental mouse fibrosis. We foun...

journal_title：Scientific reports

authors： Chen J,Argemi J,Odena G,Xu MJ,Cai Y,Massey V,Parrish A,Vadigepalli R,Altamirano J,Cabezas J,Gines P,Caballeria J,Snider N,Sancho-Bru P,Akira S,Rusyn I,Gao B,Bataller R

更新日期：2020-09-23 00:00:00

abstract：:A common spinning toy, called "buzzer", consists of a perforated disk and flexible threads. Despite of its simple construction, a buzzer can effectively transfer translational motions into high-speed rotations. In the present work, we find that the disk can be spun by hand at an extremely high rotational speed, e.g., ...

journal_title：Scientific reports

authors： Zhao ZL,Zhou S,Xu S,Feng XQ,Xie YM

更新日期：2017-10-13 00:00:00

abstract：:The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...

journal_title：Scientific reports

authors： Zhang D,Shang T,Huang Y,Wang S,Liu H,Wang J,Wang Y,Ji H,Zhang R

更新日期：2017-11-17 00:00:00

abstract：:Changes of intracellular and extracellular pH are involved in a variety of physiological and pathological processes, in which regulation of the Ca(2+) release activated Ca(2+) channel (I CRAC) by pH has been implicated. Ca(2+) entry mediated by I CRAC has been shown to be regulated by acidic or alkaline pH. Whereas se...

journal_title：Scientific reports

authors： Tsujikawa H,Yu AS,Xie J,Yue Z,Yang W,He Y,Yue L

更新日期：2015-11-18 00:00:00

abstract：:Aim of this study was to establish a simple and highly reproducible physiological circulation model to investigate endovascular device performance. The developed circulation model included a pneumatically driven pulsatile pump to generate a flow rate of 2.7 L/min at 70 beats per minute. Sections from the superficial f...

journal_title：Scientific reports

authors： Rusch R,Trentmann J,Hummitzsch L,Rusch M,Aludin S,Haneya A,Albrecht M,Schäfer JP,Puehler T,Cremer J,Berndt R

更新日期：2019-11-22 00:00:00

abstract：:G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-...

journal_title：Scientific reports

authors： Callegaro S,Perrone R,Scalabrin M,Doria F,Palù G,Richter SN

更新日期：2017-05-24 00:00:00

abstract：:In this study, an anatase/rutile mixed-phase titanium dioxide (TiO2) hierarchical network deposited with Au nanoparticles (Au/TiO2 ARHN) was synthesized using a facile hydrothermal method followed by a simple calcination step. Such a unique structure was designed for improving the light harvest, charge transportation/...

journal_title：Scientific reports

authors： Yen YC,Chen JA,Ou S,Chen YS,Lin KJ

更新日期：2017-02-10 00:00:00