Abstract:
:Mortuary practices in human evolution record cognitive, social changes and technological innovations. The Neolithic Revolution in the Levant was a watershed in this domain that has long fascinated the archaeological community. Plaster modelled skulls are well known at Jericho and several other Neolithic sites, and in Nahal Hemar cave (Israel, ca. 8200 -7300 cal. BC) excavations yielded six unique human skulls covered with a black organic coating applied in a net pattern evoking a headdress. This small cave was used as storage for paraphernalia in the semi-arid area of the Judean desert and the dry conditions preserved other artefacts such as baskets coated with a similar dark substance. While previous analysis had revealed the presence of amino acids consistent with a collagen signature, in the present report, specific biomarkers were characterised using combined proteomic and lipid approaches. Basket samples yielded collagen and blood proteins of bovine origin (Bos genus) and a large sequence coverage of a plant protein charybdin (Charybdis genus). The skull residue samples were dominated by benzoate and cinnamate derivatives and triterpenes consistent with a styrax-type resin (Styrax officinalis), thus providing the earliest known evidence of an odoriferous plant resin used in combination with an animal product.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Solazzo C,Courel B,Connan J,van Dongen BE,Barden H,Penkman K,Taylor S,Demarchi B,Adam P,Schaeffer P,Nissenbaum A,Bar-Yosef O,Buckley Mdoi
10.1038/srep31053subject
Has Abstractpub_date
2016-08-09 00:00:00pages
31053issn
2045-2322pii
srep31053journal_volume
6pub_type
历史文章,杂志文章abstract::Automatically detecting and grading cancerous regions on radical prostatectomy (RP) sections facilitates graphical and quantitative pathology reporting, potentially benefitting post-surgery prognosis, recurrence prediction, and treatment planning after RP. Promising results for detecting and grading prostate cancer on...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66849-2
更新日期:2020-06-18 00:00:00
abstract::Short-term exposures to outdoor air pollutants have been associated with lower lung function, but the results are inconsistence. The effects of different pollutant levels on lung function changes are still unclear. We quantified the effects of outdoor air pollution exposure (NO2, PM10, O3, and PM2.5) on lung function ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34947
更新日期:2016-10-13 00:00:00
abstract::Key calcifying reef taxa are currently threatened by thermal stress associated with elevated sea surface temperatures (SST) and reduced calcification linked to ocean acidification (OA). Here we undertook an 8 week experimental exposure to near-future climate change conditions and explored the microbiome response of th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19324
更新日期:2016-01-13 00:00:00
abstract::Hypocotyl elongation is considered an important typical seedling trait contributing directly to an increase in and stabilization of the yield in Brassica napus, but its molecular genetic mechanism is poorly understood. In the present study, hypocotyl lengths of 210 lines were measured in an illuminated culture room. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41561
更新日期:2017-01-31 00:00:00
abstract::cAMP is one of the most important second messengers in biological processes. Cellular dynamics of cAMP have been investigated using a series of fluorescent indicators; however, their sensitivity was sub-optimal for detecting cAMP dynamics at a low concentration range, due to a low ligand affinity and/or poor dynamic r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20251-1
更新日期:2018-01-30 00:00:00
abstract::CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20656-y
更新日期:2018-02-02 00:00:00
abstract::Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to better treatments for hearing disorders. To elucidate the transcriptional control mechanisms specifying the progenitor cells (i.e. prosen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45515-2
更新日期:2019-06-21 00:00:00
abstract::The ability of the cerebellar cortex to learn from experience ensures the accuracy of movements and reflex adaptation, processes which require long-term plasticity at granule cell (GC) to Purkinje neuron (PN) excitatory synapses. PNs also receive GABAergic inhibitory inputs via GCs activation of interneurons; despite ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33561
更新日期:2016-09-19 00:00:00
abstract::Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10738
更新日期:2015-06-04 00:00:00
abstract::LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/s41598-017-15712-y
更新日期:2017-11-10 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Previous studies on the association between Helicobacter pylori (HP) infection and NAFLD are inconsistent. Our study was aimed to find out the relationship between HP infection and NAFLD. We performed a large cross-sectional study in northern Chinese...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41371-2
更新日期:2019-03-19 00:00:00
abstract::Materials' mechanical properties highly depend on their internal structures. Designing novel structure is an effective route to improve materials' performance. One-dimensional disordered (ODD) structure is a kind of particular structure in silicon carbide (SiC), which highly affects its mechanical properties. Herein, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67652-9
更新日期:2020-07-09 00:00:00
abstract::The regulation of aquatic carbon cycles by temperature is a significant uncertainty in our understanding of how watersheds will respond to climate change. Aquatic ecosystems transport substantial quantities of carbon to the atmosphere and ocean, yet we have limited understanding of how temperature modifies aquatic eco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53703-3
更新日期:2019-11-26 00:00:00
abstract::VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in autophagy-related cell death has not been elucidated yet. We found that rVvhA significantly increased LC3 puncta formation and autopha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27080
更新日期:2016-06-02 00:00:00
abstract::PROspective MOtion correction (PROMO) can prevent motion artefacts. The aim of this study was to determine whether brain structure measurements of motion-corrected images with PROMO were reliable and equivalent to conventional images without motion artefacts. The following T1-weighted images were obtained in healthy s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38366
更新日期:2016-12-05 00:00:00
abstract::Refracture of cemented vertebrae occurs commonly after vertebroplasty (VP) for osteoporotic vertebral compression fracture (OVCF). It can result in severe pain or neurological deficit, but no preventive medication is available. Owing to the bone anabolic benefits of teriparatide (TP), this study was aimed to compare t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62869-0
更新日期:2020-04-07 00:00:00
abstract::Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08786-1
更新日期:2017-08-21 00:00:00
abstract::Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18302-0
更新日期:2017-12-22 00:00:00
abstract::Gait speed in laboratory settings (in-laboratory gait speed) is one of the important indicators associated with the decline in functional abilities in older adulthood. Recently, it has become possible to measure gait speed during daily living (daily gait speed) using accelerometers. However, the relationship between t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39695-0
更新日期:2019-03-05 00:00:00
abstract::Dysregulation in cytokine production has been linked to the pathogenesis of various immune-mediated traits, in which genetic variability contributes to the etiopathogenesis. GWA studies have identified many genetic variants in or near cytokine genes, nonetheless, the translation of these findings into knowledge of fun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71018-6
更新日期:2020-09-07 00:00:00
abstract::Albacore tuna (Thunnus alalunga) is an important target of tuna fisheries in the Atlantic and Indian Oceans. The commercial catch of albacore is the highest globally among all temperate tuna species, contributing around 6% in weight to global tuna catches over the last decade. The accurate assessment and management of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72369-w
更新日期:2020-09-24 00:00:00
abstract::Cry1A insecticidal toxins bind sequentially to different larval gut proteins facilitating oligomerization, membrane insertion and pore formation. Cry1Ac interaction with cadherin triggers oligomerization. However, a mutation in an ABC transporter gene (ABCC2) is linked to Cry1Ac resistance in Plutella xylostella. Cry1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02545-y
更新日期:2017-05-24 00:00:00
abstract::Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48677-1
更新日期:2019-08-27 00:00:00
abstract::Transport of mesoscale particles due to driving flow fields or external forces on a periodic surface appears in many areas. Geometrical and physical characteristics of particles affect the velocities of the particles in these periodic landscapes. In this paper, we present a numerical simulation based on solving the La...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75187-2
更新日期:2020-10-26 00:00:00
abstract::MALDI-TOF spectrometry has not been used for urinary exosome analysis. We used it for determining UC biomarkers. From 2012 to 2015, we enrolled 129 consecutive patients with UC and 62 participants without UC. Exosomes from their urine were isolated, and analyzed through MALDI-TOF spectrometry. Immunohistochemical (IHC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34446
更新日期:2016-09-30 00:00:00
abstract::APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus. Although effects of APOBEC3 members on viral DNA have been demonstrated, it is not know...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24448-2
更新日期:2018-04-13 00:00:00
abstract::N(1)-methyladenosine (m(1)A) is a prominent RNA modification involved in many biological processes. Accurate identification of m(1)A site is invaluable for better understanding the biological functions of m(1)A. However, limitations in experimental methods preclude the progress towards the identification of m(1)A site...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31080
更新日期:2016-08-11 00:00:00
abstract::The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46341
更新日期:2017-04-12 00:00:00
abstract::Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22926-1
更新日期:2018-03-20 00:00:00
abstract::The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results in the induction of expression of diverse genes and production of a broad spectrum of biological and toxic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47138-z
更新日期:2019-07-23 00:00:00