Abstract:
:Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic significance of Rab27 expression in solid cancer. Data were extracted by searching on PubMed, Embase and Cochrane library until February 15 2020. Pooled hazard ratio (HR) with confidence interval (CI) was calculated to evaluate the association between Rab27 expression and survival in solid cancer. Ten studies with 1434 cancer patients were including for this meta-analysis. High expression of Rab27 was associated with poor survival (HR 2.67, 95% CI 1.52-4.69, p = 0.001). High expression of Rab27A was significantly associated with lymph node metastasis (HR 1.53, 95% CI 1.00-2.34, p = 0.048). High expression of Rab27B was significantly correlated with lymph node and distant metastasis (HR 2.15, 95% CI 1.56-2.95, p < 0.001; HR 6.80, 95% CI 3.12-14.85, p < 0.001), and higher TNM stage (HR 2.55, 95% CI 1.78-3.65, p < 0.001). This meta-analysis revealed that Rab27 expression could be a potential prognostic marker in solid cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Koh HM,Jang BG,Kim DCdoi
10.1038/s41598-020-71104-9subject
Has Abstractpub_date
2020-08-24 00:00:00pages
14136issue
1issn
2045-2322pii
10.1038/s41598-020-71104-9journal_volume
10pub_type
杂志文章,meta分析abstract::Baited remote underwater video cameras were deployed in the Eastern Canadian Arctic, for the purpose of estimating local densities of the long-lived Greenland shark within five deep-water, data-poor regions of interest for fisheries development and marine conservation in Nunavut, Canada. A total of 31 camera deploymen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-19115-x
更新日期:2018-01-17 00:00:00
abstract::This study aims to assess the utility of internet search query analysis in pertussis surveillance. This study uses an empirical time series model based on internet search metrics to detect the pertussis incidence in Australia. Our research demonstrates a clear seasonal pattern of both pertussis infections and Google T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11195-z
更新日期:2017-09-05 00:00:00
abstract::We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06945
更新日期:2014-11-06 00:00:00
abstract::Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75016-6
更新日期:2020-10-22 00:00:00
abstract::The striped venus (Chamelea gallina) is an important economic resource in the Mediterranean Basin; this species has exhibited a strong quantitative decline in the Adriatic Sea. The aim of this work was to provide a comprehensive view of the biological status of C. gallina to elucidate the bioecological characteristics...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75984-9
更新日期:2020-11-05 00:00:00
abstract::Clarifying the fundamental adsorption and diffusion process of CO2 on single crystal ZnO surfaces is critical in understanding CO2 activation and transformation over ZnO-based catalysts. By using ultrahigh vacuum-Fourier transform infrared spectroscopy (UHV-FTIRS), we observed the fine structures of CO2 vibrational ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43442
更新日期:2017-03-06 00:00:00
abstract::Ulvan, which is one of the major structural polysaccharides of the cell walls of green macroalgae, is degraded by ulvan lyases via the β-elimination mechanism with the release of oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (∆) at the non-reducing end. These ulvan lyases belong ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32922-0
更新日期:2018-10-02 00:00:00
abstract::Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52090-z
更新日期:2019-11-01 00:00:00
abstract::This retrospective cohort study aims to assess the clinical and urodynamic outcomes of single-incision mesh surgery with the Uphold system. The medical records of 140 women with anterior and/or apical compartment prolapse stage 2 or greater who underwent Uphold mesh surgeries were reviewed. The clinical evaluation inc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69886-z
更新日期:2020-08-11 00:00:00
abstract::Reversible phosphorylation of proteins and the assembly of thylakoid complexes are the important protective mechanism against environmental stresses in plants. This research was aimed to investigate the different responses of the antioxidant defense system and photosystem II (PSII) to osmotic stress between drought-re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13145-1
更新日期:2017-10-05 00:00:00
abstract::Aquaculture has become imperative to cover the demands for dietary animal protein. Simultaneously, it has to overcome prejudices from excessive use of antibiotics and environmental impacts. Natural supplements are traditionally applied orally. In this study, we demonstrated another pathway: the gills. Humic substances...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80449-0
更新日期:2021-01-08 00:00:00
abstract::Identification of patients with early stage non-small cell lung cancer (NSCLC) with high risk of recurrence could help identify patients who would receive additional benefit from adjuvant therapy. In this work, we present a computational histomorphometric image classifier using nuclear orientation, texture, shape, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13773-7
更新日期:2017-10-19 00:00:00
abstract::Media reports of a celebrity's suicide may be followed by copycat suicides, and the impact may vary in different age and sex subgroups. We proposed a quantitative framework to assess the vulnerability of age and sex subgroups to copycat suicide and used this method to investigate copycat suicides in relation to the su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53833-8
更新日期:2019-11-21 00:00:00
abstract::Dengue fever is one of the most important mosquito-borne viral infections in large parts of tropical and subtropical countries and is a significant public health concern and socioeconomic burden. There is an urgent need to develop antivirals that can effectively reduce dengue virus (DENV) replication and decrease vira...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45095-1
更新日期:2019-06-18 00:00:00
abstract::Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA dou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58746-5
更新日期:2020-02-07 00:00:00
abstract::In this study, we investigated virioplankton decay rates and their responses to changes in temperature and photosynthetically active radiation (PAR) in the western Pacific Ocean. The mean decay rates for total, high-fluorescence, and low-fluorescence viruses were 1.64 ± 0.21, 2.46 ± 0.43, and 1.57 ± 0.26% h-1, respect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19678-3
更新日期:2018-01-24 00:00:00
abstract::Ubiquinol-cytochrome c reductase hinge protein (UQCRH) is the hinge protein for the multi-subunit complex III of the mitochondrial electron transport chain and is involved in the electron transfer reaction between cytochrome c1 and c. Recent genome-wide transcriptomic and epigenomic profiling of clear cell renal cell ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72107-2
更新日期:2020-09-14 00:00:00
abstract::In this study, we analyzed mutants of Clostridium acetobutylicum, an organism used in a broad range of industrial processes related to biofuel production, to facilitate future studies of bioreactor and bioprocess design and scale-up, which are very important research projects for industrial microbiology applications. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39875
更新日期:2017-01-03 00:00:00
abstract::Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37393
更新日期:2016-11-23 00:00:00
abstract::Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatechin-(epicatechin)7 gallate using electron-spray ionization time-of-flight mass sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48603-5
更新日期:2019-08-19 00:00:00
abstract::Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08842-w
更新日期:2017-08-15 00:00:00
abstract::We investigated in this paper a novel bilayer composite obtained by sol-gel and spin coating of the ferroelectric 0.92Na0.5Bi0.5TiO3-0.08BaTiO3 (abbreviated as BNT-BT0.08) and ferromagnetic CoFe2O4 phases, for miniature low-frequency magnetic sensors and piezoelectric sensors. This heterostructure, deposited on Si-Pt ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36232-3
更新日期:2018-12-14 00:00:00
abstract::Congruence theory has many applications in physical, social, biological and technological systems. Congruence arithmetic has been a fundamental tool for data security and computer algebra. However, much less attention was devoted to the topological features of congruence relations among natural numbers. Here, we explo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23714
更新日期:2016-03-31 00:00:00
abstract::The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resist...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39413
更新日期:2016-12-19 00:00:00
abstract::Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13803-4
更新日期:2017-10-17 00:00:00
abstract::The dissolution of ferrihydrite induced by low molar mass (LMM) organics is an important process that provides bioavailable iron for organisms. Here, ATR-FTIR analysis was combined with characterization of ferrihydrite nanoparticles and kinetic modeling to investigate the roles of different oxalate surface complex spe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20401-5
更新日期:2018-02-01 00:00:00
abstract::A cell-type saturable absorber has been demonstrated by filling the single mode photonic crystal fiber (SMPCF) with tungsten disulfide (WS2) nanosheets. The modulation depth, saturable intensity, and non-saturable loss of this SA are measured to be 3.53%, 159 MW/cm(2) and 23.2%, respectively. Based on this SA, a passi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12587
更新日期:2015-07-27 00:00:00
abstract::Despite recent advances in cancer management and therapy, resistance to cytotoxic medications remains a major clinical challenge; hence, combination-based anti-cancer treatment regimens are currently gaining momentum. PTC-209 reduced BMI1 protein expression, while palbociclib inhibited CDK4, Rb, and pRbSer795 protein ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50140-0
更新日期:2019-09-23 00:00:00
abstract::Colour polymorphism may be maintained within a population by disruptive-selection. One hypothesis proposes that different morphs are adapted to different ambient light conditions, with lighter morphs having a selective advantage in bright conditions and darker morphs having advantages in darker conditions. The mechani...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07829-x
更新日期:2017-08-22 00:00:00
abstract::Proton irradiation is often used as a proxy for neutron irradiation but the irradiated layer is typically <50 μm deep; this presents a problem when trying to obtain mechanical test data as a function of irradiation level. Two novel methodologies have been developed to record stress-strain curves for thin proton-irradi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62241-2
更新日期:2020-03-24 00:00:00