Abstract：
:Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatechin-(epicatechin)7 gallate using electron-spray ionization time-of-flight mass spectrometry. Epigallocatechin-(epicatechin)7 gallate (compound 1) showed significant anti-cancer activity in PC-3 prostate cancer cells. In particular, compound 1 suppressed the gene expression of fatty acid-binding protein 5 (FABP5), which is involved in promoting cell proliferation and metastasis in prostate cancer cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sei-Ichi K,Toda K,Matsumoto K,Ishihara C,Nonobe S,Matsunaga C,Gomi YK,Senga S,Kawaguchi K,Yamamoto A,Suwannachot J,Noda R,Kobayashi S,Hamauzu Y,Makabe H,Fujii Hdoi
10.1038/s41598-019-48603-5subject
Has Abstractpub_date
2019-08-19 00:00:00pages
12046issue
1issn
2045-2322pii
10.1038/s41598-019-48603-5journal_volume
9pub_type
杂志文章abstract：:The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10984
更新日期：2015-06-04 00:00:00
abstract：:Severe sepsis and septic shock are life-threatening conditions, with Gram-negative organisms responsible for most sepsis mortality. Systemic administration of compounds that block the action of lipopolysaccharide (LPS), a constituent of the Gram-negative outer cell membrane, is hampered by their hydrophobicity and cat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29739
更新日期：2016-07-14 00:00:00
abstract：:Although 3,5,3'-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks. To determine the functional relevance of these bioactive THs, RNA-seq ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14913-9
更新日期：2017-11-08 00:00:00
abstract：:Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) activated oxidization processes in improving anaerobically digested sludge (ADS) dewaterability. The combination of Fe(II) (0-100 mg/g total solids ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24800
更新日期：2016-04-25 00:00:00
abstract：:Volcanic activity is often preceded or accompanied by different types of seismo-volcanic signals. Among these signals, the so-called tornillo (Spanish for "screw") events are considered to belong to a unique class of volcano-seismicity characterised by a long-duration coda, amplitude modulation and high-quality factor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43842-y
更新日期：2019-05-14 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57571-0
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abstract：:Keyboards and smartphones allow users to express their thoughts freely via manual control. Hands-free communication can be realized with brain-computer interfaces (BCIs) based on code-modulated visual evoked potentials (c-VEPs). Various variations of such spellers have been developed: Low-target systems, multi-target ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74143-4
更新日期：2020-10-13 00:00:00
abstract：:Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07607-9
更新日期：2017-08-15 00:00:00
abstract：:Soils - constituting the largest terrestrial carbon pool - are vulnerable to climatic warming. Currently existing uncertainties regarding carbon fluxes within terrestrial systems can be addressed by studies of past carbon cycle dynamics and related climate change recorded in sedimentary successions. Here we show an ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31930
更新日期：2016-08-24 00:00:00
abstract：:Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08663-x
更新日期：2017-08-18 00:00:00
abstract：:A new approach for achieving two - dimensional (2D) atom localization microscopy based on the projection of three - dimensional (3D) localization in the plane of the detector is described in the present work. Spatial variation of the position-dependent 2D-localization pattern in the xy-plane is obtained with the shift...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57141-z
更新日期：2020-01-17 00:00:00
abstract：:Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examined. Fibroblasts from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14313-z
更新日期：2017-10-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41591
更新日期：2017-01-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56431-w
更新日期：2019-12-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33911-z
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04600-0
更新日期：2017-06-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03208
更新日期：2013-11-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-06-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63459-w
更新日期：2020-04-14 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34163
更新日期：2016-09-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-09-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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