Transcription factor ZNF148 is a negative regulator of human muscle differentiation.

Abstract:

:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen T

doi

10.1038/s41598-017-08267-5

subject

Has Abstract

pub_date

2017-08-15 00:00:00

pages

8138

issue

1

issn

2045-2322

pii

10.1038/s41598-017-08267-5

journal_volume

7

pub_type

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