Abstract:
:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bakke J,Wright WC,Zamora AE,Ong SS,Wang YM,Hoyer JD,Brewer CT,Thomas PG,Chen Tdoi
10.1038/s41598-017-08267-5subject
Has Abstractpub_date
2017-08-15 00:00:00pages
8138issue
1issn
2045-2322pii
10.1038/s41598-017-08267-5journal_volume
7pub_type
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