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Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy.

Abstract：

:Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examined. Fibroblasts from patients or a mouse model of SMA released exosomes containing reduced levels of SMN protein relative to normal controls. Cells overexpressing SMN protein released exosomes with dramatically elevated levels of SMN protein. We observed enhanced quantities of exosomes in the medium from SMN-depleted cells, and in serum from a mouse model of SMA and a patient with Type 3 SMA, suggesting that SMN-depletion causes a deregulation of exosome release or uptake. The quantity of SMN protein contained in the serum-derived exosomes correlated with the genotype of the animal, with progressively less protein in carrier and affected animals compared to wildtype mice. SMN protein was easily detectable in exosomes isolated from human serum, with a reduction in the amount of SMN protein in exosomes from a patient with Type 3 SMA compared to a normal control. Our results suggest that exosome-derived SMN protein may serve as an effective biomarker for SMA.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nash LA,McFall ER,Perozzo AM,Turner M,Poulin KL,De Repentigny Y,Burns JK,McMillan HJ,Warman Chardon J,Burger D,Kothary R,Parks RJ

doi

10.1038/s41598-017-14313-z

subject

Has Abstract

pub_date

2017-10-24 00:00:00

pages

13859

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14313-z

journal_volume

7

pub_type

杂志文章

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