DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.

abstract：:The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-engineering due to its simplicity, flexibility, and high efficiency. Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system. This raised the possibilit...

journal_title：Scientific reports

authors： Kimura Y,Hisano Y,Kawahara A,Higashijima S

更新日期：2014-10-08 00:00:00

abstract：:Teleportation plays an important role in the communication of quantum information between the nodes of a quantum network and is viewed as an essential ingredient for long-distance Quantum Cryptography. We describe a method to teleport the quantum information carried by a photon in a superposition of a number d of ligh...

journal_title：Scientific reports

authors： Goyal SK,Konrad T

更新日期：2013-12-19 00:00:00

abstract：:Some neural network can be trained by transfer learning, which uses a pre-trained neural network as the source task, for a small target task's dataset. The performance of the transfer learning depends on the knowledge (i.e., layers) selected from the pre-trained network. At present, this knowledge is usually chosen by...

journal_title：Scientific reports

authors： Imai S,Kawai S,Nobuhara H

更新日期：2020-05-18 00:00:00

abstract：:Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a...

journal_title：Scientific reports

authors： Uchida K,Himori N,Hashimoto K,Shiga Y,Tsuda S,Omodaka K,Nakazawa T

更新日期：2020-01-17 00:00:00

abstract：:In this study, electromechanical characteristics of (1-x) Bi0.5Na0.5TiO3-xSrTiO3 (ST26, x = 0.26)/(1-y) Bi0.5Na0.5TiO3-ySrTiO3 (ST10, y = 0.1) (matrix/seed) composites were studied. The ST26 (high relaxor phase) and ST10 (a relaxor ferroelectric (RF), high ferroelectric phase) composite with large (r-ST26-ST10) and sm...

journal_title：Scientific reports

authors： Saleem M,Hwan LD,Kim IS,Kim MS,Maqbool A,Nisar U,Pervez SA,Farooq U,Farooq MU,Khalil HMW,Jeong SJ

更新日期：2018-09-20 00:00:00

abstract：:Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe2+ to regulate biosynthesis rate...

journal_title：Scientific reports

authors： Khan MA,Walden WE,Theil EC,Goss DJ

更新日期：2017-08-17 00:00:00

abstract：:Over the years, electrophysiological recordings in macaque monkeys performing visuomotor tasks brought about accumulating evidence for the expression of neuronal properties (e.g., selectivity in the visuospatial and somatosensory domains, encoding of visual affordances and motor cues) in the posterior parietal area V6...

journal_title：Scientific reports

authors： Santandrea E,Breveglieri R,Bosco A,Galletti C,Fattori P

更新日期：2018-05-02 00:00:00

abstract：:This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in comb...

journal_title：Scientific reports

authors： Patterson E,Wall R,Lisai S,Ross RP,Dinan TG,Cryan JF,Fitzgerald GF,Banni S,Quigley EM,Shanahan F,Stanton C

更新日期：2017-03-07 00:00:00

abstract：:In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal chromatography (COFRADIC), were performed using tissue samples from th...

journal_title：Scientific reports

authors： Brea D,Agulla J,Staes A,Gevaert K,Campos F,Sobrino T,Blanco M,Dávalos A,Castillo J,Ramos-Cabrer P

更新日期：2015-07-08 00:00:00

abstract：:Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...

journal_title：Scientific reports

authors： Hoxmeier JC,Thompson BD,Broeckling CD,Small P,Foy BD,Prenni J,Dobos KM

更新日期：2015-03-18 00:00:00

abstract：:A relation exists between network proximity of molecular entities in interaction networks, functional similarity and association with diseases. The identification of network regions associated with biological functions and pathologies is a major goal in systems biology. We describe a network diffusion-based pipeline f...

journal_title：Scientific reports

authors： Bersanelli M,Mosca E,Remondini D,Castellani G,Milanesi L

更新日期：2016-10-12 00:00:00

abstract：:We present new evidence that shows magma mingling can be a key process during highly explosive eruptions. Using fractal analysis of the size distribution of trachybasaltic fragments found on the inner walls of bubbles in trachytic pumices, we show that the more mafic component underwent fracturing during quenching aga...

journal_title：Scientific reports

authors： Paredes-Mariño J,Dobson KJ,Ortenzi G,Kueppers U,Morgavi D,Petrelli M,Hess KU,Laeger K,Porreca M,Pimentel A,Perugini D

更新日期：2017-12-04 00:00:00

abstract：:The definition of the gene expression profile of genes encoding Ion Channels and Transporters (ICT-GEP) represents a novel and attracting aspect in cancer. We determined the ICT-GEP of Follicular Lymphoma (FL), and compared it with that of the more aggressive Diffuse Large B Cell Lymphoma (DLBCL). cDNA microarray data...

journal_title：Scientific reports

authors： Magi A,Masselli M,Sala C,Guerriero A,Laise P,Puccini B,Rigacci L,Breschi C,Crociani O,Pillozzi S,Arcangeli A

更新日期：2019-06-13 00:00:00

abstract：:A physically active lifestyle is associated with better health in body and mind, and it is urgent that supporting agents for such lifestyles be developed. In rodents, voluntary locomotor activity as an active physical behavior may be mediated by dopaminergic neurons (DNs). Thiamine phosphate esters can stimulate DNs, ...

journal_title：Scientific reports

authors： Saiki M,Matsui T,Soya M,Kashibe T,Shima T,Shimizu T,Naruto T,Kitayoshi T,Akimoto K,Ninomiya S,Soya H

更新日期：2018-07-11 00:00:00

abstract：:William Adams (Miura Anjin) was an English navigator who sailed with a Dutch trading fleet to the far East and landed in Japan in 1600. He became a vassal under the Shogun, Tokugawa Ieyasu, was bestowed with a title, lands and swords, and became the first SAMURAI from England. "Miura" comes from the name of the territ...

journal_title：Scientific reports

authors： Mizuno F,Ishiya K,Matsushita M,Matsushita T,Hampson K,Hayashi M,Tokanai F,Kurosaki K,Ueda S

更新日期：2020-12-10 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisatio...

journal_title：Scientific reports

authors： Azlan A,Obeidat SM,Yunus MA,Azzam G

更新日期：2019-08-21 00:00:00

abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

journal_title：Scientific reports

authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

更新日期：2020-12-01 00:00:00

abstract：:Zika virus infection and dengue and chikungunya fevers are emerging viral diseases that have become public health threats. Their aetiologic agents are transmitted by the bite of genus Aedes mosquitoes. Without effective therapies or vaccines, vector control is the main strategy for preventing the spread of these disea...

journal_title：Scientific reports

authors： Lopez SBG,Guimarães-Ribeiro V,Rodriguez JVG,Dorand FAPS,Salles TS,Sá-Guimarães TE,Alvarenga ESL,Melo ACA,Almeida RV,Moreira MF

更新日期：2019-03-11 00:00:00

abstract：:Local communities are assembled from larger-scale species pools via dispersal, environmental filtering, biotic interactions, and local stochastic demographic processes. The relative importance, scaling and interplay of these assembly processes can be elucidated by comparing local communities to variously circumscribed...

journal_title：Scientific reports

authors： Feng G,Mi X,Eiserhardt WL,Jin G,Sang W,Lu Z,Wang X,Li X,Li B,Sun I,Ma K,Svenning JC

更新日期：2015-03-23 00:00:00

abstract：:Fatigue is a very common and costly symptom associated with various diseases and disorders. Nonetheless, understanding the pathobiology and developing of therapies for fatigue have been difficult, partly because of a lack of consensus on the measures to phenotype this behavior, both in clinical settings and in animal ...

journal_title：Scientific reports

authors： Wolff BS,Raheem SA,Saligan LN

更新日期：2018-09-24 00:00:00

abstract：:Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. In this manner, 2D crystals, precisely layered double hydroxides, have attracted the attention of scientists due to their significant adjustability and low-toxicity and low-cost preparation ...

journal_title：Scientific reports

authors： Rabiee N,Bagherzadeh M,Ghadiri AM,Salehi G,Fatahi Y,Dinarvand R

更新日期：2020-11-26 00:00:00

abstract：:Biochar (BC) and magnetite (Fe3O4) nanoparticles (MNP) have both received considerable recent attention in part due to their potential use in water treatment. While both are effective independently in the removal of a range of anionic metals from aqueous solution, the efficacy of these materials is reduced considerabl...

journal_title：Scientific reports

authors： Alam MS,Bishop B,Chen N,Safari S,Warter V,Byrne JM,Warchola T,Kappler A,Konhauser KO,Alessi DS

更新日期：2020-11-04 00:00:00

abstract：:Cytochrome P450 superfamily proteins play important roles in detoxification of xenobiotics and during physiological and developmental processes. To contribute to our understanding of this large gene family in insects, we have investigated the function of the cytochrome P450 gene LmCYP4G102 in the migratory locust Locu...

journal_title：Scientific reports

authors： Yu Z,Zhang X,Wang Y,Moussian B,Zhu KY,Li S,Ma E,Zhang J

更新日期：2016-07-22 00:00:00

abstract：:We report abnormal magnetic field effects on electrogenerated chemiluminescence (MFEECL) based on triplet emission from the Ru(bpy)3Cl2-TPrA electrochemical system: the appearance of MFEECL after magnetic field ceases. In early studies the normal MFEECL have been observed from electrochemical systems during the applic...

journal_title：Scientific reports

authors： Pan H,Shen Y,Wang H,He L,Hu B

更新日期：2015-03-16 00:00:00

abstract：:Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been sh...

journal_title：Scientific reports

authors： Bax HJ,Bowen H,Dodev TS,Sutton BJ,Gould HJ

更新日期：2015-04-20 00:00:00

abstract：:The high neutron detection efficiency, good gamma-ray discrimination and non-toxicity of 3He made of proportional counters filled with this gas the obvious choice for neutron detection, particularly in radiation portal monitors (RPM), used to control the illicit transport of nuclear material, of which neutron detector...

journal_title：Scientific reports

authors： Amaro FD,Monteiro CM,Dos Santos JM,Antognini A

更新日期：2017-02-09 00:00:00

abstract：:The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic signi...

journal_title：Scientific reports

authors： Li G,Sun K,Guo J,Li S,Li B,Cao J,Lu P,Yang J,Zhang Y,Yang X,Gao L,He Y,Cui T,Ma B

更新日期：2017-07-12 00:00:00

abstract：:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine en...

journal_title：Scientific reports

authors： Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosens

更新日期：2017-10-03 00:00:00

abstract：:Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes. The determination of cellular senescence is time consuming and logistically intensive. Here, we propose the use of endogenous autofluoresc...

journal_title：Scientific reports

authors： Bertolo A,Baur M,Guerrero J,Pötzel T,Stoyanov J

更新日期：2019-02-14 00:00:00

abstract：:Circulating compounds such as drugs and nutritional components might adhere to the oxygenator fibers and tubing during ECMO support. This study evaluated the amount of nutritional supplements adsorbed to the ECMO circuit under controlled ex vivo conditions. Six identical ECMO circuits were primed with fresh human whol...

journal_title：Scientific reports

authors： Lindberg BR,Videm V,Dahl T,Sørensen G,Fiane AE,Thiara AS

更新日期：2020-11-06 00:00:00