UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells.

abstract：:Aedes aegypti mosquitoes are the primary vectors of numerous viruses that impact human health. As manipulation of reproduction has been proposed to suppress mosquito populations, elucidation of biological processes that enable males and females to successfully reproduce is necessary. One essential process is female sp...

journal_title：Scientific reports

authors： Camargo C,Ahmed-Braimah YH,Amaro IA,Harrington LC,Wolfner MF,Avila FW

更新日期：2020-09-10 00:00:00

abstract：:The study of factors influencing animal intake can provide a better understanding of the dynamics of the pasture ecosystem and serve as a basis for managing livestock in a more efficient way. We measured different sward surface heights of tall fescue in the process of short-term intake rate of sheep. There was a signi...

journal_title：Scientific reports

authors： Szymczak LS,de Moraes A,Sulc RM,Monteiro ALG,Lang CR,Moraes RF,da Silva DFF,Bremm C,de Faccio Carvalho PC

更新日期：2020-07-16 00:00:00

abstract：:Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...

journal_title：Scientific reports

authors： Lei X,Yu J,Niu Q,Liu J,Fraering PC,Wu F

更新日期：2015-11-16 00:00:00

abstract：:Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...

journal_title：Scientific reports

authors： C MA,K P F,Singh S,Baik S

更新日期：2016-10-07 00:00:00

abstract：:Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp.) and the viral co...

journal_title：Scientific reports

authors： Lester PJ,Buick KH,Baty JW,Felden A,Haywood J

更新日期：2019-04-08 00:00:00

abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

journal_title：Scientific reports

authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

更新日期：2018-07-16 00:00:00

abstract：:Soil fauna are critical for ecosystem function and sensitive to the changes of soil fertility. The effects of fertilization on soil fauna communities, however, remain poorly understood. We examined the effects of fertilization form and quantity on the abundance, diversity and composition of soil fauna across an age-se...

journal_title：Scientific reports

authors： Wang S,Chen HY,Tan Y,Fan H,Ruan H

更新日期：2016-02-09 00:00:00

abstract：:We combine matter-wave interferometry and cavity optomechanics to propose a coherent matter-light interface based on mechanical motion at the quantum level. We demonstrate a mechanism that is able to transfer non-classical features imprinted on the state of a matter-wave system to an optomechanical device, transducing...

journal_title：Scientific reports

authors： Xuereb A,Ulbricht H,Paternostro M

更新日期：2013-11-29 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

journal_title：Scientific reports

authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

更新日期：2019-01-23 00:00:00

abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...

journal_title：Scientific reports

authors： Tervaniemi MH,Katayama S,Skoog T,Siitonen HA,Vuola J,Nuutila K,Sormunen R,Johnsson A,Linnarsson S,Suomela S,Kankuri E,Kere J,Elomaa O

更新日期：2016-03-15 00:00:00

abstract：:The Acer truncatum Bunge is a particular widespread forest tree species in northern China. VLCFAs are important to eukaryotes survival and play diverse roles throughout the development. So far, there are reports that the Acer truncatum seeds fatty acid (FA) rich in VLCFAs, but little is known about the physiological m...

journal_title：Scientific reports

authors： Wang R,Liu P,Fan J,Li L

更新日期：2018-10-19 00:00:00

abstract：:Increased ultraviolet B (UVB) radiation due to global change can affect plant growth and metabolism. Here, we evaluated the capacity of quinoa to resist under short acute UVB irradiation. Quinoa was daily exposed for 30 or 60 min to 1.69 W m-2 UVB. The results showed that 30 min exposure in 9 d-course did not cause se...

journal_title：Scientific reports

authors： Huarancca Reyes T,Scartazza A,Castagna A,Cosio EG,Ranieri A,Guglielminetti L

更新日期：2018-01-10 00:00:00

abstract：:mRNAs containing premature termination codons (PTCs) are rapidly degraded through nonsense-mediated mRNA decay (NMD). However, some PTC-containing mRNAs evade NMD, and might generate mutant proteins responsible for various diseases, including cancers. Using PTC-containing human genomic β-globin constructs, we show tha...

journal_title：Scientific reports

authors： Kim WK,Yun S,Kwon Y,You KT,Shin N,Kim J,Kim H

更新日期：2017-11-20 00:00:00

abstract：:We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or...

journal_title：Scientific reports

authors： Moorhouse FJ,Cornell S,Gerstl L,Tacke M,Roser T,Heinen F,Bonfert M,von Stülpnagel C,Wagner M,Borggraefe I

更新日期：2020-12-09 00:00:00

abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...

journal_title：Scientific reports

authors： Kim HS,Choi JH,Lee JY,Kang J,Myung JK,Kim WH,Jang BG

更新日期：2020-03-17 00:00:00

abstract：:Ammonia physiology is important to numerous disease states including urea cycle disorders and hepatic encephalopathy. However, many unknowns persist regarding the ammonia response to common and potentially significant physiologic influences, such as food. Our aim was to evaluate the dynamic range of ammonia in respons...

journal_title：Scientific reports

authors： Spacek LA,Strzepka A,Saha S,Kotula J,Gelb J,Guilmain S,Risby T,Solga SF

更新日期：2018-02-07 00:00:00

abstract：:Proteins are of interest in nano-bio electronic devices due to their versatile structures, exquisite functionality and specificity. However, quantum transport measurements produce conflicting results due to technical limitations whereby it is difficult to precisely determine molecular orientation, the nature of the mo...

journal_title：Scientific reports

authors： Sheu SY,Yang DY

更新日期：2017-01-04 00:00:00

abstract：:Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play a crucial role in growth and development, as well as metabolic processes. However, knowledge of the function of LBD proteins in Camellia sinensis is limited, and no systematic investigations of the LBD family have been re...

journal_title：Scientific reports

authors： Zhang X,He Y,He W,Su H,Wang Y,Hong G,Xu P

更新日期：2019-10-30 00:00:00

abstract：:Phytophthora blight is one of the most serious diseases affecting melon (Cucumis melo) production. Due to the lack of highly resistant germplasms, the progress on disease-resistant research is slow. To understand the genetics of melon resistance to Phytophthora capsici, an F2 population containing 498 individuals was ...

journal_title：Scientific reports

authors： Wang P,Xu X,Zhao G,He Y,Hou C,Kong W,Zhang J,Liu S,Xu Y,Xu Z

更新日期：2020-11-24 00:00:00

abstract：:Multiplexed gene expression optimization via modulation of gene translation efficiency through ribosome binding site (RBS) engineering is a valuable approach for optimizing artificial properties in bacteria, ranging from genetic circuits to production pathways. Established algorithms design smart RBS-libraries based o...

journal_title：Scientific reports

authors： Oesterle S,Gerngross D,Schmitt S,Roberts TM,Panke S

更新日期：2017-09-26 00:00:00

abstract：:Although thimerosal, an ethylmercury-based preservative, has been removed from most pediatric vaccines in the United States, some multidose vaccines, such as influenza vaccines, still contain thimerosal. Considering that a growing number of studies indicate involvement of the gut microbiome in infant immune developmen...

journal_title：Scientific reports

authors： Hasegawa Y,Curtis B,Yutuc V,Rulien M,Morrisroe K,Watkins K,Ferrier C,English C,Hewitson L,Slupsky CM

更新日期：2018-10-26 00:00:00

abstract：:Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and ...

journal_title：Scientific reports

authors： Gayen Nee' Betal S,Murthy S,Favara M,Fong G,Chan JSY,Addya S,Shaffer TH,Greenspan J,Bhandari V,Rahman I,Aghai ZH

更新日期：2019-04-10 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00

abstract：:The Edinburgh Postnatal Depression Scale (EPDS) is frequently used to screen for postpartum depression. However, its factor structure exhibits noticeable inconsistencies between studies. We examined the EPDS at two postpartum time points using a large dataset from outside Western countries. Participants were 91,063 mo...

journal_title：Scientific reports

authors： Matsumura K,Hamazaki K,Tsuchida A,Kasamatsu H,Inadera H,Japan Environment and Children’s Study (JECS) Group.

更新日期：2020-07-15 00:00:00

abstract：:Leukotriene E4 (LTE4) the most stable of the cysteinyl leukotrienes (cysLTs) binds poorly to classical type 1 (CysLT1) and 2 (CysLT2) receptors although it induces potent responses in human airways in vivo, such as bronchoconstriction, airway hyperresponsiveness and inflammatory cell influx suggesting the presence of ...

journal_title：Scientific reports

authors： Foster HR,Fuerst E,Branchett W,Lee TH,Cousins DJ,Woszczek G

更新日期：2016-02-02 00:00:00

abstract：:The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In this study, we pre...

journal_title：Scientific reports

authors： Gupta S,Biswas A,Akhter MS,Krettler C,Reinhart C,Dodt J,Reuter A,Philippou H,Ivaskevicius V,Oldenburg J

更新日期：2016-07-25 00:00:00

abstract：:Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (RV), was evaluated for the delivery of HIV-1 immunogens. Recombinant RV-HIV viruses were engineered to stably e...

journal_title：Scientific reports

authors： Giel-Moloney M,Esteban M,Oakes BH,Vaine M,Asbach B,Wagner R,Mize GJ,Spies AG,McElrath J,Perreau M,Roger T,Ives A,Calandra T,Weiss D,Perdiguero B,Kibler KV,Jacobs B,Ding S,Tomaras GD,Montefiori DC,Ferrari G,Yates

更新日期：2019-12-27 00:00:00

abstract：:We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

journal_title：Scientific reports

authors： Liu F,Koepp DM,Walters KJ

更新日期：2015-07-14 00:00:00

abstract：:Alcohol consumption is one of the major causes of hepatic steatosis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Ethanol metabolism alters the NAD(+)/NADH ratio, thereby suppressing the activity of sirtuin family proteins, which may affect lipid metabolism in liver cells. However, it is not clear h...

journal_title：Scientific reports

authors： Yu JH,Song SJ,Kim A,Choi Y,Seok JW,Kim HJ,Lee YJ,Lee KS,Kim JW

更新日期：2016-07-11 00:00:00

abstract：:Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analys...

journal_title：Scientific reports

authors： Goto-Inoue N,Yamada K,Inagaki A,Furuichi Y,Ogino S,Manabe Y,Setou M,Fujii NL

更新日期：2013-11-20 00:00:00