Abstract：
:In this study, we analyzed mutants of Clostridium acetobutylicum, an organism used in a broad range of industrial processes related to biofuel production, to facilitate future studies of bioreactor and bioprocess design and scale-up, which are very important research projects for industrial microbiology applications. To accomplish this, we generated 329 mutant strains and applied principal component analysis (PCA) to fermentation data gathered from these strains to identify a core set of independent features for comparison. By doing so, we were able to explain the differences in the mutant strains' fermentation expression states and simplify the analysis and visualization of the multidimensional datasets related to the strains. Our study has produced a high-efficiency PCA application based on a data analytics tool that is designed to visualize screening results and to support several hundred sets of data on fermentation interactions to assist researchers in more precisely screening and capturing high-quality mutant strains. More importantly, although this study focused on the use of PCA in microbial fermentation engineering, its results are broadly applicable.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhou X,Xu D,Jiang TTdoi
10.1038/srep39875subject
Has Abstractpub_date
2017-01-03 00:00:00pages
39875issn
2045-2322pii
srep39875journal_volume
7pub_type
杂志文章abstract：:Cyanobacteria are ubiquitous organisms with a relevant contribution to primary production in all range of habitats. Cyanobacteria are well known for their part in worldwide occurrence of aquatic blooms while producing a myriad of natural compounds, some with toxic potential, but others of high economical impact, as ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64774-y
更新日期：2020-05-26 00:00:00
abstract：:Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions have been reported. In this report, we evaluated the effects of gene-smoking interactions on lung function using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27463-5
更新日期：2018-06-18 00:00:00
abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation of diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with the activation of host innate immune respo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06610-4
更新日期：2017-07-25 00:00:00
abstract：:Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49766-x
更新日期：2019-09-13 00:00:00
abstract：:It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and Decem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54285-w
更新日期：2019-11-29 00:00:00
abstract：:Hormone sensitive lipase (HSL) activation is part of the metabolic adaptations to the negative energy balance common to the mammalian periparturient period. This study determined HSL contribution to adipose tissue (AT) lipolysis and how insulin regulates its activity in periparturient dairy cows. Subcutaneous AT (SCAT...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31582-4
更新日期：2018-09-06 00:00:00
abstract：:Infrared detection devices are becoming miniature with micro or nano-scale size. The advantages of downsizing come on the expense of insufficient collection of infrared radiation. Therefore, utilizing nano-plasmonic optical antennas becomes mandatory. However, it is desirable to develop antennas with broad bandwidth, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48648-6
更新日期：2019-08-21 00:00:00
abstract：:Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00651-5
更新日期：2017-04-06 00:00:00
abstract：:The Fanconi anemia pathway in coordination with homologous recombination is essential to repair interstrand crosslinks (ICLs) caused by cisplatin. TIP60 belongs to the MYST family of acetyltransferases and is involved in DNA repair and regulation of gene transcription. Although the physical interaction between the TIP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04223-5
更新日期：2017-06-20 00:00:00
abstract：:The melting of glaciers and ice sheets is nowadays considered a symbol of climate change. Many complex mechanisms are involved in the melting of ice, and, among these processes, surface darkening due to organic material on bare ice has recently received attention from the scientific community. The presence of microbes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61762-0
更新日期：2020-03-16 00:00:00
abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23258-w
更新日期：2018-03-19 00:00:00
abstract：:The programmed induction of meiotic DNA double-strand breaks (DSBs) by the evolutionarily conserved SPO-11 protein, which is structurally related to archaeal Topo VIA topoisomerases, triggers meiotic recombination. Identification of several meiosis-specific factors that are required for SPO-11-mediated DSB formation r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02641-z
更新日期：2017-05-24 00:00:00
abstract：:Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31906-4
更新日期：2018-09-10 00:00:00
abstract：:The basic leucine zipper (bZIP) is a widely known transcription factors family in eukaryotes. In plants, the role of bZIP proteins are crucial in various biological functions such as plant growth and development, seed maturation, response to light signal and environmental stress. To date, bZIP protein family has been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72390-z
更新日期：2020-09-23 00:00:00
abstract：:DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA interaction, and by examining on it the influence of DNA binding drugs. We observed that the DNA condensation is accompanied by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41975-8
更新日期：2019-04-10 00:00:00
abstract：:Molecular taxonomy often uncovers cryptic species, reminding us that taxonomic incompleteness is even more severe than previous thought. The importance of cryptic species for conservation is poorly understood. Although some cryptic species may be seriously threatened or otherwise important, they are rarely included in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02938-z
更新日期：2017-06-13 00:00:00
abstract：:Extracellular vesicles (EVs), such as exosomes, have garnered increasing interest because of their potential clinical applications that range from diagnostics to therapeutics. The development of an automated and reproducible EV purification platform would therefore aid the introduction of EV biomarkers and therapies i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75561-0
更新日期：2020-10-30 00:00:00
abstract：:Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize that phosphate deficiency altered the circadian cycle in peripheral tissues. Analysis of the expression of the central clock g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31830-7
更新日期：2018-09-13 00:00:00
abstract：:The analysis of equine electrocardiographic (ECG) recordings is complicated by the absence of agreed abnormality classification criteria. We explore the applicability of several complexity analysis methods for characterization of non-linear aspects of electrocardiographic recordings. We here show that complexity estim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38935-7
更新日期：2019-02-22 00:00:00
abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited known vendor colony-based differences in endocrine/immune responses to gain insig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00652-4
更新日期：2017-04-06 00:00:00
abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46285-7
更新日期：2019-07-09 00:00:00
abstract：:Metformin is one of the treatments used for PCOS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin's effects on lipid metabolism, a crucial process in PCOS pathology. We have employed a lipidomic approach to explore alterations in the plasma...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-019-52263-w
更新日期：2019-11-05 00:00:00
abstract：:The purpose of this meta-analysis was to compare the efficacy and safety of regional anesthesia to manage chronic postsurgery pain. A systematic search of PubMed, EmBase, and the Cochrane Central Register of Controlled Trials was performed to identify randomized controlled trials that focused on chronic pain frequency...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-00813-5
更新日期：2017-04-06 00:00:00
abstract：:The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18595-1
更新日期：2018-01-08 00:00:00
abstract：:Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanism...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36273
更新日期：2016-11-03 00:00:00
abstract：:The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to characterize the effects of spaceflight and reentry to 1 g on the structure and integrity of the retina and blood-retinal barrier (BRB) in the eye. To ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44696-0
更新日期：2019-06-03 00:00:00
abstract：:Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17679-2
更新日期：2017-12-13 00:00:00
abstract：:Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37129-x
更新日期：2019-01-24 00:00:00
abstract：:The metabolic balance of the most extensive bioma on the Earth is a controversial topic of the global-change research. High ultraviolet radiation (UVR) levels by the shoaling of upper mixed layers and increasing atmospheric dust deposition from arid regions may unpredictably alter the metabolic state of marine oligotr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35892
更新日期：2016-10-24 00:00:00
abstract：:A child with Down syndrome, like any other child, may benefit from interacting with memory stimuli, but needs additional support and help. The use of special teaching methods, which add playfulness and use of the computer, can enhance the memory processes of these children. In this work, we present the virtual environ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60014-5
更新日期：2020-02-21 00:00:00
