Abstract：
:Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isolated from clinical specimens of NFPAs with or without bone destruction. Proteomic analysis revealed a group of molecules associated with cytoskeleton organization, including caldesmon, were differentially expressed between fibroblasts isolated from bone destruction NFPAs (BD-NFPAs) and fibroblasts isolated from non-bone destruction NFPAs (NBD-NFPAs). The secreted proteins analysis found that osteopontin was significantly upregulated in BD-NFPAs fibroblasts. Furthermore, immunohistochemical staining of the NFPAs clinical samples showed that the expression of caldesmon in stromal cells and the expression of osteopontin in both tumor cells and stroma were significantly increased in BD-NFPAs. Taken together, our results indicate a possible way that osteopontin secreted from both NFPA cells and surrounding fibroblasts modify caldesmon expression and polymerization in fibroblasts, which may contribute to bone destruction in NFPA patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang LY,Ge XL,Li Z,Tang YJ,Xiong YY,Li XJ,Liu JF,Wanggou SY,Li CT,Yang K,Chen X,Hu ZL,Liu YS,Liu ZXdoi
10.1038/s41598-017-17679-2subject
Has Abstractpub_date
2017-12-13 00:00:00pages
17523issue
1issn
2045-2322pii
10.1038/s41598-017-17679-2journal_volume
7pub_type
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