Abstract：
:Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neonates between 1 Jan 2014 and 31 Dec 2014. 5.6% neonates in our study were SGA. Serum samples were collected during second and third trimesters for evaluation on fasting lipids levels. The present study intended to explore the associations between maternal lipid profile and small-for-gestational-age neonates. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated and adjusted via logistic regression analysis. After adjustments for confounders, third-trimester total cholesterol levels were associated with a decreased risk for small-for-gestational-age (aOR = 0.622, 95% CI 0.458-0.848, P = 0.002), and third-trimester high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were associated with an increased risk for small-for-gestational-age (aOR = 1.955, 95% CI 1.465-2.578, P < 0.001; aOR = 1.403, 95% CI 1.014-1.944, P = 0.041).In the highest gestational weight gain strata, especially the third-trimester, the effect of high-density lipoprotein cholesterol levels on the risk for small-for-gestational-age is larger. High high-density lipoprotein cholesterol level during third trimester could be considered as indicators of a high-risk of small-for-gestational-age, regardless of gestational weight gain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen Q,Chen H,Xi F,Sagnelli M,Zhao B,Chen Y,Yang M,Xu D,Jiang Y,Chen G,Luo Qdoi
10.1038/s41598-020-76845-1subject
Has Abstractpub_date
2020-11-16 00:00:00pages
19865issue
1issn
2045-2322pii
10.1038/s41598-020-76845-1journal_volume
10pub_type
杂志文章abstract：:Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the relaxivity and sensitivity for detection of native ferritin is relatively low. We report here on a novel chimeric magneto-ferritin reporter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26550
更新日期：2016-05-23 00:00:00
abstract：:The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10010-z
更新日期：2017-08-25 00:00:00
abstract：:Passive immunotherapy with monoclonal antibodies (mAbs) is an efficacious treatment for Ebola virus (EBOV) infections in animal models and humans. Understanding what constitutes a protective response is critical for the development of novel therapeutic strategies. We generated an EBOV-glycoprotein-pseudotyped Human im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45552
更新日期：2017-03-30 00:00:00
abstract：:Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the conse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52808-z
更新日期：2019-11-08 00:00:00
abstract：:Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01242-0
更新日期：2017-04-27 00:00:00
abstract：:The increased prevalence of childhood obesity is expected to translate in the near future into a concomitant soaring of multiple cardio-metabolic diseases. Obesity has a complex, multifactorial etiology, that includes multiple and multidomain potential risk factors: genetics, dietary and physical activity habits, soci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81205-8
更新日期：2021-01-21 00:00:00
abstract：:Ebola virus disease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans. The association of EVD outbreaks with forest clearance has been suggested previously but many aspects remained uncharacterized. We used remote sensing techniques to investigate the association between deforestation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14727-9
更新日期：2017-10-30 00:00:00
abstract：:Land use change is one of the important aspects of the regional ecological restoration research. With remote sensing (RS) image in 2003, 2007 and 2012, using geographic information system (GIS) technologies, the land use pattern changes in Yimeng Mountain ecological restoration area in China and its driving force fact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11038
更新日期：2015-06-05 00:00:00
abstract：:The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04206
更新日期：2014-02-26 00:00:00
abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42271
更新日期：2017-02-13 00:00:00
abstract：:It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less is known about the functions of the catabolites of haem in mammalian cells. Haem is enzymatically degraded to iron, carbon monoxide (CO), and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10488
更新日期：2015-05-20 00:00:00
abstract：:Denitrification in coastal sediments can provide resilience to eutrophication in estuarine ecosystems, but this key ecosystem function is impacted directly and indirectly by increasing stressors. The erosion and loading of fine sediments from land, resulting in sedimentation and elevated sediment muddiness, presents a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54192-0
更新日期：2019-11-26 00:00:00
abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-26671-3
更新日期：2018-05-29 00:00:00
abstract：:Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based coh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48065-9
更新日期：2019-08-08 00:00:00
abstract：:Adolescent alcohol exposure may increase anxiety-like behaviors by altering central monoaminergic functions and other important neuronal pathways. The present study was designed to investigate the anxiolytic effect of 0.5% γ-oryzanol (GORZ) and its neurochemical and molecular mechanisms under chronic 10% ethanol consu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67689-w
更新日期：2020-06-30 00:00:00
abstract：:ATP depletion and succinate accumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion. In contrast, freshwater turtles survive weeks of anoxia at low temperatures without suffering from oxidative damage upon reoxygenation, but the mechanisms are unclear. To determine how turtles surviv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39836-5
更新日期：2019-02-26 00:00:00
abstract：:During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59759-w
更新日期：2020-02-20 00:00:00
abstract：:Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36323-1
更新日期：2018-12-18 00:00:00
abstract：:The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22351
更新日期：2016-02-29 00:00:00
abstract：:The ratio of ω-6 to ω-3 polyunsaturated fatty acids (PUFAs) appears to be critical in the regulation of various pathophysiological processes and to maintain cellular homeostasis. While a high proportion of dietary intake of ω-6 PUFAs is associated with various inflammatory disorders, higher intake of ω-3 PUFAs is know...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31649
更新日期：2016-08-18 00:00:00
abstract：:Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 3...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/srep32195
更新日期：2016-08-31 00:00:00
abstract：:The study explored differences in the steroidogenic pathway between obese and nonobese women with polycystic ovary syndrome (PCOS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 1044 women with PCOS (including 350 lean, 312 overweight and 382 obese) and 366 control women without PCOS (including 203 l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14534-2
更新日期：2017-10-26 00:00:00
abstract：:Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive f...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12027-w
更新日期：2017-09-19 00:00:00
abstract：:The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions with diverse bindin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36622
更新日期：2016-11-09 00:00:00
abstract：:The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58455-z
更新日期：2020-02-03 00:00:00
abstract：:A three dimensional (3D) numerical solution of unsteady, Ag-MgO hybrid nanoliquid flow with heat and mass transmission caused by upward/downward moving of wavy spinning disk has been scrutinized. The magnetic field has been also considered. The hybrid nanoliquid has been synthesized in the presence of Ag-MgO nanoparti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75905-w
更新日期：2020-11-02 00:00:00
abstract：:Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved in atopy. This study aimed to explore the impact of lentiviral-mediated shRNA silencing KCa3.1 on allergic response in a murine allergic rhinitis (AR) model. The BALB/c mice were divided into four group...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13127
更新日期：2015-08-14 00:00:00
abstract：:In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate was 29.9%. In the p53-negative group, median disease free survival (DFS), and time from primary breast cancer diagnosis to death (OS1), time f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02246
更新日期：2013-01-01 00:00:00
abstract：:We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08054
更新日期：2015-01-27 00:00:00
abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42366
更新日期：2017-02-15 00:00:00
