Abstract：
:Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the consequences of experimental AHT on Abcc6-/- PXE mouse models. Experimental AHT was induced by deoxycorticosterone acetate (DOCA-salt) in uni-nephrectomised mice. Blood pressure (BP) and vascular reactivity were monitored using tail-cuff plethysmography and myography respectively. Calcium content and fibrosis were assessed using colorimetry, Von Kossa and Sirius red staining respectively. The gene expression implicated in vascular biology was measured using quantitative polymerase chain reaction. DOCA-salt induced a matching rise in BP in Abcc6-/- and WT mice. Aortic ring contraction and relaxation in vitro were comparable. Calcium accumulated in the hearts of hypertensive Abcc6-/- mice along with significant fibrosis in the myocardium and aorta by contrast with the WT mice. In hypertensive Abcc6-/- mouse aortas, these results were corroborated by gene expression patterns favouring calcification, fibrosis and extracellular matrix remodelling. Abcc6 loss-of-function is associated with greater cardiovascular calcification and fibrosis in mice subjected to DOCA-Salt hypertension. These results suggest likely cardiovascular deterioration in PXE patients with AHT, necessitating diligent BP monitoring.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Omarjee L,Roy C,Leboeuf C,Favre J,Henrion D,Mahe G,Leftheriotis G,Martin L,Janin A,Kauffenstein Gdoi
10.1038/s41598-019-52808-zsubject
Has Abstractpub_date
2019-11-08 00:00:00pages
16327issue
1issn
2045-2322pii
10.1038/s41598-019-52808-zjournal_volume
9pub_type
杂志文章abstract：:We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29315-8
更新日期：2018-07-20 00:00:00
abstract：:Spin-wave dynamics in full-Heusler Co2FeAl0.5Si0.5 films are studied using all-optical pump-probe magneto-optical polar Kerr spectroscopy. Backward volume magnetostatic spin-wave (BVMSW) mode is observed in films with thickness ranging from 20 to 100 nm besides perpendicular standing spin-wave (PSSW) mode, and found t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42513
更新日期：2017-02-14 00:00:00
abstract：:Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00544
更新日期：2012-01-01 00:00:00
abstract：:Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10589
更新日期：2015-06-12 00:00:00
abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11713-z
更新日期：2017-09-12 00:00:00
abstract：:Viral oncoproteins E6/E7 play key oncogenic role in human papillomavirus (HPV)-mediated cervical carcinogenesis in conjunction with aberrant activation of cellular signaling events. GLI-signaling has been implicated in metastasis and tumor recurrence of cervical cancer. However, the interaction of GLI-signaling with H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34377
更新日期：2016-09-28 00:00:00
abstract：:Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have roles in cell-to-cell signaling, biofilm formation, and stress responses. Here, the effects of abiotic stressors on OMV contents and composition from biofilm cells of the plant health-promoting bacterium Pseudomonas chlororaphis O6 (PcO6) are exami...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78357-4
更新日期：2020-12-04 00:00:00
abstract：:Recent studies demonstrate that the invasion and metastasis of gastric cancer (GC) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase). Here we investigated the expression and role of the human ATP6V1A gene that encodes the catalytic subunit A of V-ATPase in GC. We found that ATP6V1A expression le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03021-3
更新日期：2017-06-07 00:00:00
abstract：:We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14398-6
更新日期：2017-10-25 00:00:00
abstract：:Land use, habitat, and forage quality have emerged as critical factors influencing the health, productivity, and survival of honey bee colonies. However, characterization of the mechanistic relationship between differential land-use conditions and ultimate outcomes for honey bee colonies has been elusive. We assessed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52485-y
更新日期：2019-11-07 00:00:00
abstract：:Topoisomerases II (Top2s) are a group of essential enzymes involved in replication, transcription, chromosome condensation, and segregation via altering DNA topology. The mechanism of the Top2s poisons such as etoposide (VP-16) was reported as stabilizing the Top2-DNA complex and engendering permanent DNA breakage. As...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33366-2
更新日期：2018-10-08 00:00:00
abstract：:The present study evaluated the physiological, molecular and hormonal parameters from scion/rootstock interaction of citrus plants during recurrent water deficit. Responses of the Valencia (VO) scion variety grafted on two rootstocks with different soil water extraction capacities, Rangpur Lime (RL) and Sunki Maravilh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14161-x
更新日期：2017-10-20 00:00:00
abstract：:The structural and magnetic properties of seven CeMn2Ge(2-x)Six compounds with x = 0.0-2.0 have been investigated in detail. Substitution of Ge with Si leads to a monotonic decrease of both a and c along with concomitant contraction of the unit cell volume and significant modifications of the magnetic states - a cross...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11288
更新日期：2015-06-19 00:00:00
abstract：:Thyroid nodules can be classified into benign and malignant tumors. However, distinguishing between these two types of tumors can be challenging in clinics. Since malignant nodules require surgical intervention whereas asymptomatic benign tumors do not, there is an urgent need for new techniques that enable accurate d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14869
更新日期：2015-10-21 00:00:00
abstract：:Detonation nanodiamonds (NDs) were deposited on the surface of aligned carbon nanotubes (CNTs) by immersing a CNT array in an aqueous suspension of NDs in dimethylsulfoxide (DMSO). The structure and electronic state of the obtained CNT-ND hybrid material were studied using optical and electron microscopy and Infrared,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09379
更新日期：2015-03-23 00:00:00
abstract：:Fetal cardiomyocytes actively proliferate to form the primitive heart in utero in mammals, but they stop dividing shortly after birth. The identification of essential molecules maintaining this active cardiomyocyte proliferation is indispensable for potential adult heart regeneration. A recent study has shown that thi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04823-1
更新日期：2017-06-30 00:00:00
abstract：:Channelrhodopsins are light-gated ion channels of green algae used for the precise temporal and spatial control of transmembrane ion fluxes. The channelrhodopsin Chrimson from Chlamydomonas noctigama allows unprecedented deep tissue penetration due to peak absorption at 590 nm. We demonstrate by electrophysiological r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09600-8
更新日期：2017-08-30 00:00:00
abstract：:Lithium vanadium phosphate (Li3V2(PO4)3, LVP)/reduced graphene oxide (rGO) composite is prepared with a rheological method followed by heat treatment. The size and interface of LVP particles, two important merits for a cathode material, can be effectively tuned by the rGO in the composite, which plays as surfactant to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05768
更新日期：2014-08-29 00:00:00
abstract：:The push for a semiconductor-based quantum information technology has renewed interest in the spin states and optical transitions of shallow donors in silicon, including the donor bound exciton transitions in the near-infrared and the Rydberg, or hydrogenic, transitions in the mid-infrared. The deepest group V donor i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10493
更新日期：2015-05-20 00:00:00
abstract：:Spin switching of organometallic complexes by ferromagnetic surfaces is an important topic in the area of molecular nanospintronics. Moreover, graphene has been shown as a 2D surface for physisorption of molecular magnets and strain engineering on graphene can tune the spin state of an iron porphyrin (FeP) molecule fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03405
更新日期：2013-12-03 00:00:00
abstract：:To assess the response of lichen elemental compositions to road traffic and species difference in the context of high dust input and anthropogenic emissions, two foliose epiphytic lichens (Phaeophyscia hirtuosa, PHh; Candelaria fibrosa, CAf) were sampled near a road adjacent to Dolon Nor Town (Duolun County, Inner Mon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06027-z
更新日期：2017-07-17 00:00:00
abstract：:Plutella xylostella has become the major lepidopteran pest of Brassica owing to its strong ability of resistance development to a wide range of insecticides. Destruxin A, a mycotoxin of entomopathogenic fungus, Metarhizium anisopliae, has broad-spectrum insecticidal effects. However, the interaction mechanism of destr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11298-7
更新日期：2017-09-08 00:00:00
abstract：:Increased glucose uptake and aerobic glycolysis are striking features of many cancers. These features have led to many techniques for screening and diagnosis, but many are expensive, less feasible or have harmful side-effects. Here, we report a sensitive 1H/2H NMR method to measure the kinetics of lactate isotopomer a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65839-8
更新日期：2020-06-01 00:00:00
abstract：:Previous studies have documented that decompression led to endothelial dysfunction with controversial results. This study aimed to clarify the relationship between endothelial dysfunction, bubble formation and decompression rate. Rats were subjected to simulated air dives with one of four decompression rates: one slow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33390
更新日期：2016-09-12 00:00:00
abstract：:One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31232-9
更新日期：2018-09-10 00:00:00
abstract：:We introduce a simple criterion to identify two-dimensional (2D) materials based on the comparison between experimental lattice constants and lattice constants mainly obtained from Materials-Project (MP) density functional theory (DFT) calculation repository. Specifically, if the relative difference between the two la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05402-0
更新日期：2017-07-12 00:00:00
abstract：:Materials' mechanical properties highly depend on their internal structures. Designing novel structure is an effective route to improve materials' performance. One-dimensional disordered (ODD) structure is a kind of particular structure in silicon carbide (SiC), which highly affects its mechanical properties. Herein, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67652-9
更新日期：2020-07-09 00:00:00
abstract：:For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60388-6
更新日期：2020-02-26 00:00:00
abstract：:That the human brain contains magnetite is well established; however, its spatial distribution in the brain has remained unknown. We present room temperature, remanent magnetization measurements on 822 specimens from seven dissected whole human brains in order to systematically map concentrations of magnetic remanence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29766-z
更新日期：2018-07-27 00:00:00
abstract：:Obesity involves alterations in transcriptional programs that can change in response to genetic and environmental signals through chromatin modifications. Since chromatin modifications involve different biochemical, neurological and molecular signaling pathways related to energy homeostasis, we hypothesize that geneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22231-x
更新日期：2018-03-02 00:00:00
