Lentiviral shRNA against KCa3.1 inhibits allergic response in allergic rhinitis and suppresses mast cell activity via PI3K/AKT signaling pathway.

abstract：:Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO2 satellite measurements from the Ozone Monitoring Instrument (OMI) and groun...

journal_title：Scientific reports

authors： Jia Y,Yu G,Gao Y,He N,Wang Q,Jiao C,Zuo Y

更新日期：2016-01-27 00:00:00

abstract：:We present a novel, all-electric approach to record and to precisely control the activity of tens of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of multiple synapses and of the resulting dynamics of postsynaptic neurons in a cortical culture. For the measurements, we combine ...

journal_title：Scientific reports

authors： Jäckel D,Bakkum DJ,Russell TL,Müller J,Radivojevic M,Frey U,Franke F,Hierlemann A

更新日期：2017-04-20 00:00:00

abstract：:The purpose of this study is to investigate whether implementing a myofascial release (MFR) protocol designed to restore the myofascial properties of the diaphragm has any effect on the symptoms, quality of life, and consumption of proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal reflux...

journal_title：Scientific reports

authors： Martínez-Hurtado I,Arguisuelas MD,Almela-Notari P,Cortés X,Barrasa-Shaw A,Campos-González JC,Lisón JF

更新日期：2019-05-13 00:00:00

abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

journal_title：Scientific reports

authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

更新日期：2017-07-27 00:00:00

abstract：:We report here the design and multiple functions of a new hierarchical nanotheronostic platform consisting of an upconversion nanoparticle (UCNP) core: shell with an additional mesoporous silica (mSiO2) matrix load shell containing sealed, high concentration of ICG molecules. We demonstrate that this UCNP@mSiO2-ICG na...

journal_title：Scientific reports

authors： Lv R,Wang D,Xiao L,Chen G,Xia J,Prasad PN

更新日期：2017-11-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Dainese E,Oddi S,Simonetti M,Sabatucci A,Angelucci CB,Ballone A,Dufrusine B,Fezza F,De Fabritiis G,Maccarrone M

更新日期：2020-03-31 00:00:00

abstract：:Telomerase is expressed in adult mouse, but not in most human, tissues and mouse telomeres are much longer than those in humans. This interspecies difference of telomere homeostasis poses a challenge in modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosome reporters, we dis...

journal_title：Scientific reports

authors： Cheng,Zhao Y,Zhang F,Zhang J,Wang S,Zhu J

更新日期：2019-07-04 00:00:00

abstract：:p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...

journal_title：Scientific reports

authors： Rycenga HB,Wolfe KB,Yeh ES,Long DT

更新日期：2019-07-17 00:00:00

abstract：:Membrane potential (Vmem) is a key bioelectric property of non-excitable cells that plays important roles in regulating cell proliferation. However, the regulation of Vmem itself remains largely unexplored. We found that, under nutrient starvation, during which cell division is inhibited, MKN45 gastric cancer cells we...

journal_title：Scientific reports

authors： Zhu L,Yu XJ,Xing S,Jin F,Yang WJ

更新日期：2018-04-16 00:00:00

abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

journal_title：Scientific reports

authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

更新日期：2015-06-10 00:00:00

abstract：:Reef sharks are vulnerable predators experiencing severe population declines mainly due to overexploitation. However, beyond direct exploitation, human activities can produce indirect or sub-lethal effects such as behavioral alterations. Such alterations are well known for terrestrial fauna but poorly documented for m...

journal_title：Scientific reports

authors： Juhel JB,Vigliola L,Wantiez L,Letessier TB,Meeuwig JJ,Mouillot D

更新日期：2019-02-27 00:00:00

abstract：:Archeological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From ...

journal_title：Scientific reports

authors： Wang X,Tang Z,Wu J,Wu X,Wu Y,Zhou X

更新日期：2016-10-20 00:00:00

abstract：:INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus encodes three tumor suppressor genes namely CDKN2A, ARF, CDKN2B and a ...

journal_title：Scientific reports

authors： Vishal M,Sharma A,Kaurani L,Chakraborty S,Ray J,Sen A,Mukhopadhyay A,Ray K

更新日期：2014-05-30 00:00:00

abstract：:We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without a...

journal_title：Scientific reports

authors： Horváth M,Horváthová V,Hájek P,Štěchovský C,Honěk J,Šenolt L,Veselka J

更新日期：2020-04-03 00:00:00

abstract：:Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...

journal_title：Scientific reports

authors： Maibohm C,Silvestre OF,Borme J,Sinou M,Heggarty K,Nieder JB

更新日期：2020-05-26 00:00:00

abstract：:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions o...

journal_title：Scientific reports

authors： Makino T,Izumi K,Hiratsuka K,Kano H,Shimada T,Nakano T,Kadomoto S,Naito R,Iwamoto H,Yaegashi H,Shigehara K,Kadono Y,Nakata H,Saito Y,Nakagawa-Goto K,Sakai N,Iwata Y,Wada T,Mizokami A

更新日期：2021-01-12 00:00:00

abstract：:Although increases in cardiovascular load (pressure overload) are known to elicit ventricular remodeling including cardiomyocyte hypertrophy and interstitial fibrosis, the molecular mechanisms of pressure overload or AngII -induced cardiac interstitial fibrosis remain elusive. In this study, serpinE2/protease nexin-1 ...

journal_title：Scientific reports

authors： Li X,Zhao D,Guo Z,Li T,Qili M,Xu B,Qian M,Liang H,E X,Chege Gitau S,Wang L,Huangfu L,Wu Q,Xu C,Shan H

更新日期：2016-11-23 00:00:00

abstract：:We examined whether alterations in body perception in EDs extend to the integration of exteroceptive visual and tactile information. Moreover, we investigated the effect of self-focused attention on the ability to correctly detect tactile stimuli. Twenty-seven women reporting low ED symptoms, versus 26 women reporting...

journal_title：Scientific reports

authors： Sacchetti S,Mirams L,McGlone F,Cazzato V

更新日期：2020-07-15 00:00:00

abstract：:Secondhand smoke (SHS) has been associated with a variety of adverse health outcomes in nonsmokers, including emphysema (a chronic obstructive pulmonary disease). One way to detect SHS exposure is to measure the concentration of cotinine, the primary metabolite of nicotine, in bodily fluids. We have developed a method...

journal_title：Scientific reports

authors： Xu X,Su Y,Fan ZH

更新日期：2014-01-27 00:00:00

abstract：:A scheme is presented to realize a single-photon transistor based on cavity quantum electrodynamics (QED) with Rydberg atomic ensemble. By combining the advantages of the cavity-enhanced interaction and Rydberg blockade, we achieve a high gain single-photon transistor. The numerical calculation shows that by using one...

journal_title：Scientific reports

authors： Hao YM,Lin GW,Lin XM,Niu YP,Gong SQ

更新日期：2019-03-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Gyamfi J,Lee YH,Eom M,Choi J

更新日期：2020-07-29 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double ...

journal_title：Scientific reports

authors： Kreuzer PM,Lehner A,Schlee W,Vielsmeier V,Schecklmann M,Poeppl TB,Landgrebe M,Rupprecht R,Langguth B

更新日期：2015-12-15 00:00:00

abstract：:A functional genetic switch from the lactococcal bacteriophage TP901-1, deciding which of two divergently transcribing promoters becomes most active and allows this bi-stable decision to be inherited in future generations requires a DNA region of less than 1 kb. The fragment encodes two repressors, CI and MOR, transcr...

journal_title：Scientific reports

authors： Pedersen M,Neergaard JT,Cassias J,Rasmussen KK,Lo Leggio L,Sneppen K,Hammer K,Kilstrup M

更新日期：2020-05-26 00:00:00

abstract：:Acute-on-chronic liver failure (ACLF) is a dynamic syndrome, and sequential assessments can reflect its prognosis more accurately. Our aim was to build and validate a new scoring system to predict short-term prognosis using baseline and dynamic data in ACLF. We conducted a retrospective cohort analysis of patients wit...

journal_title：Scientific reports

authors： Yu Z,Zhang Y,Cao Y,Xu M,You S,Chen Y,Zhu B,Kong M,Song F,Xin S,Duan Z,Han T

更新日期：2021-01-19 00:00:00

abstract：:The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their distribution in cells and tissues. In this communication we report on the synthesis of amphiphilic polypeptides bearing C-terminal phosphorescent la...

journal_title：Scientific reports

authors： Vlakh EG,Grachova EV,Zhukovsky DD,Hubina AV,Mikhailova AS,Shakirova JR,Sharoyko VV,Tunik SP,Tennikova TB

更新日期：2017-02-03 00:00:00

abstract：:Diapause, a programmed developmental arrest, is common in insects, enabling them to survive adverse seasons. It is well established that pupal diapause is regulated by ecdysteroids secreted by the prothoracic glands (PGs), with cessation of ecdysteroid secretion after pupal ecdysis leading to pupal diapause. A major f...

journal_title：Scientific reports

authors： Yamada N,Kataoka H,Mizoguchi A

更新日期：2017-01-31 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...

journal_title：Scientific reports

authors： Bulugonda RK,Kumar KA,Gangappa D,Beeda H,Philip GH,Muralidhara Rao D,Faisal SM

更新日期：2017-02-20 00:00:00

abstract：:The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...

journal_title：Scientific reports

authors： Hackelberg S,Oliver D

更新日期：2018-08-28 00:00:00

abstract：:In the Ultimatum Game, two players are offered a chance to win a pie. The proposer suggests how to split the pie. The responder can either accept or reject the deal. If an agreement is not reached, neither player gets anything. Both game theory and evolutionary game theory predict the rational solution that the propos...

journal_title：Scientific reports

authors： Wang X,Chen X,Wang L

更新日期：2014-04-01 00:00:00