Evaluation of genetic association of the INK4 locus with primary open angle glaucoma in East Indian population.

Abstract:

:INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus encodes three tumor suppressor genes namely CDKN2A, ARF, CDKN2B and a long non-coding RNA CDKN2B-AS1 (also known as ANRIL). Here, we report association study of 34 SNPs from INK4 locus with POAG in a population of Indo-European ancestry from the eastern part of India (350 patients and 354 controls). With 81% power to detect genetic association we observed only nominal association of rs1011970 (uncorrected p = 0.048) with POAG and rs10120688 (uncorrected p = 0.048) in patients without a high intra-ocular pressure (IOP<21 mm of Hg) compared to controls. This study, in contrast to the previous reports, suggests lack of significant genetic association of INK4 locus with POAG in East Indian population which needs to be replicated in larger studies in diverse world populations.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Vishal M,Sharma A,Kaurani L,Chakraborty S,Ray J,Sen A,Mukhopadhyay A,Ray K

doi

10.1038/srep05115

subject

Has Abstract

pub_date

2014-05-30 00:00:00

pages

5115

issn

2045-2322

pii

srep05115

journal_volume

4

pub_type

杂志文章
  • Supercurrent enhancement in Bloch domain walls.

    abstract::Conventional spin-singlet Cooper pairs convert into spin-triplet pairs in ferromagnetic Josephson junctions in which the superconductor/ferromagnet interfaces (S/F) are magnetically inhomogeneous. Although much of the theoretical work describing this triplet proximity effect has considered ideal junctions with magneti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00699

    authors: Robinson JW,Chiodi F,Egilmez M,Halász GB,Blamire MG

    更新日期:2012-01-01 00:00:00

  • Biogenically induced bedded chert formation in the alkaline palaeo-lake of the Green River Formation.

    abstract::Rhythmically bedded cherts are observed in both pelagic marine and lacustrine deposits, but the formation mechanism in the latter remains highly uncertain. Our study of alternating chert-dolomite beds in the Eocene Green River Formation, Utah, USA reveals dense accumulations of organic-matter spheres (30-50 μm diamete...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52862-7

    authors: Kuma R,Hasegawa H,Yamamoto K,Yoshida H,Whiteside JH,Katsuta N,Ikeda M

    更新日期:2019-11-11 00:00:00

  • Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.

    abstract::Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20608-6

    authors: Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

    更新日期:2018-02-13 00:00:00

  • A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats.

    abstract::Statins present many beneficial effects in chronic liver disease, but concerns about safety exist. We evaluated the hepatic effects of a nitric oxide-releasing atorvastatin (NCX 6560) compared to conventional statins. Simvastatin, atorvastatin and NCX 6560 were evaluated in four-week bile duct-ligated rats (BDL) simul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40461

    authors: Rodríguez S,Raurell I,Torres-Arauz M,García-Lezana T,Genescà J,Martell M

    更新日期:2017-01-13 00:00:00

  • Additional Arctic observations improve weather and sea-ice forecasts for the Northern Sea Route.

    abstract::During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16868

    authors: Inoue J,Yamazaki A,Ono J,Dethloff K,Maturilli M,Neuber R,Edwards P,Yamaguchi H

    更新日期:2015-11-20 00:00:00

  • Author Correction: Isolated terawatt attosecond hard X-ray pulse generated from single current spike.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-44364-3

    authors: Shim CH,Parc YW,Kumar S,Ko IS,Kim DE

    更新日期:2019-06-06 00:00:00

  • A Chinese Pane-Like 2D Metal-Organic Framework Showing Magnetic Relaxation and Luminescence Dual-Functions.

    abstract::The discovery of graphene kicked off the curtain of atom-type two-dimensional (2D) materials. Layered metal-organic frameworks (MOFs) as parallel molecule-based 2D materials are more designable and more diverse, and magnetism may be induced by their metal ion nodes. However, the multifunctional 2D plane-like MOFs are ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11006-5

    authors: Liu CM,Zhang DQ,Hao X,Zhu DB

    更新日期:2017-09-11 00:00:00

  • Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae.

    abstract::Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55601-0

    authors: Yang SK,Yusoff K,Thomas W,Akseer R,Alhosani MS,Abushelaibi A,Lim SH,Lai KS

    更新日期:2020-01-21 00:00:00

  • Cardiovascular Disease Risk Varies by Birth Month in Canines.

    abstract::The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25199-w

    authors: Boland MR,Kraus MS,Dziuk E,Gelzer AR

    更新日期:2018-05-17 00:00:00

  • Acfs: accurate circRNA identification and quantification from RNA-Seq data.

    abstract::Circular RNAs (circRNAs) are a group of single-stranded RNAs in closed circular form. They are splicing-generated, widely expressed in various tissues and have functional implications in development and diseases. To facilitate genome-wide characterization of circRNAs using RNA-Seq data, we present a freely available s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38820

    authors: You X,Conrad TO

    更新日期:2016-12-08 00:00:00

  • The aryl hydrocarbon receptor promotes aging phenotypes across species.

    abstract::The ubiquitously expressed aryl hydrocarbon receptor (AhR) induces drug metabolizing enzymes as well as regulators of cell growth, differentiation and apoptosis. Certain AhR ligands promote atherosclerosis, an age-associated vascular disease. Therefore, we investigated the role of AhR in vascular functionality and agi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19618

    authors: Eckers A,Jakob S,Heiss C,Haarmann-Stemmann T,Goy C,Brinkmann V,Cortese-Krott MM,Sansone R,Esser C,Ale-Agha N,Altschmied J,Ventura N,Haendeler J

    更新日期:2016-01-21 00:00:00

  • Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics.

    abstract::High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29618-w

    authors: Efremova MV,Naumenko VA,Spasova M,Garanina AS,Abakumov MA,Blokhina AD,Melnikov PA,Prelovskaya AO,Heidelmann M,Li ZA,Ma Z,Shchetinin IV,Golovin YI,Kireev II,Savchenko AG,Chekhonin VP,Klyachko NL,Farle M,Majouga AG,Wi

    更新日期:2018-07-26 00:00:00

  • WRINKLED1 transcription factor orchestrates the regulation of carbon partitioning for C18:1 (oleic acid) accumulation in Siberian apricot kernel.

    abstract::WRINKLED1 (WRI1), an APETALA2 (AP2)-type transcription factor, has been shown to be required for the regulation of carbon partitioning into fatty acid (FA) synthesis in plant seeds. To our knowledge, the regulatory network of WRI1 remains unknown in Prunus sibirica kernel (PSK), a novel woody biodiesel feedstock in Ch...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39236-9

    authors: Deng S,Mai Y,Shui L,Niu J

    更新日期:2019-02-25 00:00:00

  • Step-wise endoscopic approach to palliative bilateral biliary drainage for unresectable advanced malignant hilar obstruction.

    abstract::The ideal type of stent utilized at index endoscopic retrograde cholangiopancreatography (ERCP) in management of malignant hilar obstruction (MHO) remains unclear. We aimed to determine the ideal stent choice in patients with MHO. In this retrospective study, patients with unresectable MHO were separated into the plas...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48384-x

    authors: Choi JH,Lee SH,You MS,Shin BS,Choi YH,Kang J,Jang S,Paik WH,Ryu JK,Kim YT

    更新日期:2019-09-13 00:00:00

  • Huaier restrains proliferative and invasive potential of human hepatoma SKHEP-1 cells partially through decreased Lamin B1 and elevated NOV.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related mortality worldwide. It is urgently needed to develop potential drugs with good efficacy and low toxicity for HCC treatment. The anti-tumor effect of Traditional Chinese Medicine (TCM) has received increasing attention worldwide. Tram...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31298

    authors: Hu Z,Yang A,Su G,Zhao Y,Wang Y,Chai X,Tu P

    更新日期:2016-08-09 00:00:00

  • Molecular-trapping in Emulsion's Monolayer: A New Strategy for Production and Purification of Bioactive Saponins.

    abstract::Saponins from defatted root-extract of Securidaca longipedunculata were systematically entrapped in emulsion monolayer-barrier and finally recovered in pure form through demulsification. First, their molecules were dispersed in water to engineer a monomolecular film architecture, via self-assembly. Emulsifying with et...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15067-4

    authors: Obasi TC,Moldovan R,Toiu A,Braicu C,Bodoki E,Berindan-Neagoe I,Oniga I,Sandulescu R,Oprean R

    更新日期:2017-11-06 00:00:00

  • SLIME: robust, high-speed 3D microvascular mapping.

    abstract::Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37313-z

    authors: Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MW

    更新日期:2019-01-29 00:00:00

  • Evaluating renewable natural resources flow and net primary productivity with a GIS-Emergy approach: A case study of Hokkaido, Japan.

    abstract::Renewable natural resources, such as solar radiation, rainfall, wind, and geothermal heat, together with ecosystem services, provide the elementary supports for the sustainable development of human society. To improve regional sustainability, we studied the spatial distributions and quantities of renewable natural res...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37552

    authors: Wang C,Zhang S,Yan W,Wang R,Liu J,Wang Y

    更新日期:2016-11-18 00:00:00

  • Cytogenetic and agronomic characterization of intergeneric hybrids between Saccharum spp. hybrid and Erianthus arundinaceus.

    abstract::In sugarcane (Saccharum spp. hybrid) breeding, introgression of useful genes via intergeneric hybridization is a powerful strategy for improving the crop productivity. Erianthus arundinaceus shows great potential in terms of useful traits; however, little is known about the cytogenetic and agronomic characteristics of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38316-6

    authors: Pachakkil B,Terajima Y,Ohmido N,Ebina M,Irei S,Hayashi H,Takagi H

    更新日期:2019-02-11 00:00:00

  • Comparison of Accuracy of Arrival-Time-Insensitive and Arrival-Time-Sensitive CTP Algorithms for Prediction of Infarct Tissue Volumes.

    abstract::The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66041-6

    authors: Pennig L,Thiele F,Goertz L,Laukamp KR,Perkuhn M,Kabbasch C,Schlamann M,Fink GR,Borggrefe J

    更新日期:2020-06-09 00:00:00

  • Charge disproportionation and nano phase separation in [Formula: see text].

    abstract::We have successfully grown centimeter-sized layered [Formula: see text] single crystals under high oxygen pressures of 120-150 bar by the floating zone technique. This enabled us to perform neutron scattering experiments where we observe close to quarter-integer magnetic peaks below [Formula: see text] that are accomp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74884-2

    authors: Guo H,Li ZW,Chang CF,Hu Z,Kuo CY,Perring TG,Schmidt W,Piovano A,Schmalzl K,Walker HC,Lin HJ,Chen CT,Blanco-Canosa S,Schlappa J,Schüßler-Langeheine C,Hansmann P,Khomskii DI,Tjeng LH,Komarek AC

    更新日期:2020-10-22 00:00:00

  • Open-label placebos reduce test anxiety and improve self-management skills: A randomized-controlled trial.

    abstract::Test anxiety is a condition in which people experience extreme distress and anxiety before and in test situations. It affects up to 40 percent of all students. Conventional treatment includes both medication and psychotherapy, but studies also demonstrated that placebos affect anxiety symptoms. Although in the traditi...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-019-49466-6

    authors: Schaefer M,Denke C,Harke R,Olk N,Erkovan M,Enge S

    更新日期:2019-09-16 00:00:00

  • Physiological demands of a swimming-based video game: Influence of gender, swimming background, and exergame experience.

    abstract::Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of 40 participants playing with a swimming exergame. We recorded oxygen consumption and assessed ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05583-8

    authors: Soltani P,Figueiredo P,Ribeiro J,Fernandes RJ,Vilas-Boas JP

    更新日期:2017-07-12 00:00:00

  • Sequence analysis of the Hsp70 family in moss and evaluation of their functions in abiotic stress responses.

    abstract::The 70-kD heat shock proteins (Hsp70s) are highly conserved molecular chaperones that play essential roles in cellular processes including abiotic stress responses. Physcomitrella patens serves as a representative of the first terrestrial plants and can recover from serious dehydration. To assess the possible relation...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33650

    authors: Tang T,Yu A,Li P,Yang H,Liu G,Liu L

    更新日期:2016-09-20 00:00:00

  • Diversity hotspot and unique community structure of foraminifera in the world's deepest marine blue hole - Sansha Yongle Blue Hole.

    abstract::Marine blue holes are precious geological heritages with high scientific research values. Their physical and chemical characteristics are unique because of the steep-walled structure and isolated water column which create isolated ecosystems in geographically restricted areas. The Sansha Yongle Blue Hole (SYBH) is the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67221-0

    authors: Li Q,Lei Y,Morard R,Li T,Wang B

    更新日期:2020-06-24 00:00:00

  • An atlas for human brain myelin content throughout the adult life span.

    abstract::Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79540-3

    authors: Dvorak AV,Swift-LaPointe T,Vavasour IM,Lee LE,Abel S,Russell-Schulz B,Graf C,Wurl A,Liu H,Laule C,Li DKB,Traboulsee A,Tam R,Boyd LA,MacKay AL,Kolind SH

    更新日期:2021-01-11 00:00:00

  • Facet-specific assembly of proteins on SrTiO₃ polyhedral nanocrystals.

    abstract::Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-spec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05084

    authors: Dong L,Luo Q,Cheng K,Shi H,Wang Q,Weng W,Han WQ

    更新日期:2014-05-28 00:00:00

  • Local decomposition induced by dislocation motions inside precipitates in an Al-alloy.

    abstract::Dislocations in crystals are linear crystallographic defects, which move in lattice when crystals are plastically deformed. Motion of a partial dislocation may remove or create stacking fault characterized with a partial of a lattice translation vector. Here we report that motion of partial dislocations inside an inte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01039

    authors: Yang B,Zhou YT,Chen D,Ma XL

    更新日期:2013-01-01 00:00:00

  • Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013.

    abstract::Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08904

    authors: Huang X,Wei H,Wu S,Du Y,Liu L,Su J,Xu Y,Wang H,Li X,Wang Y,Liu G,Chen W,Klena JD,Xu B

    更新日期:2015-03-10 00:00:00

  • Appropriate reference region selection of 18F-florbetaben and 18F-flutemetamol beta-amyloid PET expressed in Centiloid.

    abstract::The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70978-z

    authors: Cho SH,Choe YS,Park S,Kim YJ,Kim HJ,Jang H,Kim SJ,Kim JP,Jung YH,Kim BC,Na DL,Moon SH,Seo SW

    更新日期:2020-09-11 00:00:00