Abstract：
:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MWdoi
10.1038/s41598-018-37313-zsubject
Has Abstractpub_date
2019-01-29 00:00:00pages
893issue
1issn
2045-2322pii
10.1038/s41598-018-37313-zjournal_volume
9pub_type
杂志文章abstract：:Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53192-4
更新日期：2019-11-22 00:00:00
abstract：:In this paper, a new type of porous ceramics was prepared using the raw sepiolite mineral. The porous ceramics was shaped by the dry pressing method and sintered in the range of 700 ~ 1200 °C. The temperature-microstructure evolution and the properties of porous sepiolite ceramics were investigated by thermo gravimetr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43918-9
更新日期：2019-05-14 00:00:00
abstract：:Adaptive optics (AO) visual simulators based on deformable mirrors, spatial light modulators or optotunable lenses are increasingly used to simulate vision through different multifocal lens designs. However, the correspondence of this simulation with that obtained through real intraocular lenses (IOLs) tested on the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38673-w
更新日期：2019-02-07 00:00:00
abstract：:There are lack of studies regarding the effects of microbial diversity on specific soil functions, such as pesticides degradation. This study evaluated the role of bacterial community diversity and biochar on chlorothalonil (CTN) degradation, using 'dilution to extinction' approach, PCR-DGGE/16S rRNA gene technique, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14803-0
更新日期：2017-11-07 00:00:00
abstract：:LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2017-11-10 00:00:00
abstract：:Nitrate molten salts are extensively used for sensible heat storage in Concentrated Solar Power (CSP) plants and thermal energy storage (TES) systems. They are the most promising materials for latent heat storage applications. By combining classical molecular dynamics and differential scanning calorimetry experiments,...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-07-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-08-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57174-4
更新日期：2020-01-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58083-7
更新日期：2020-01-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44709
更新日期：2017-03-24 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08226-0
更新日期：2017-08-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-02-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-16 00:00:00
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journal_title：Scientific reports
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更新日期：2016-11-08 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-06-22 00:00:00
abstract：:Low Haemoglobin concentration (Hb) among women of reproductive age is a severe public health problem in sub-Saharan Africa. This study investigated the effects of putative socio-demographic factors on maternal Hb at different points of the conditional distribution of Hb concentration. We utilised quantile regression t...
journal_title：Scientific reports
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