Abstract：
:One current concept suggests that unchecked proliferation of clonally selected precursors of endothelial cells (ECs) contribute to severe pulmonary arterial hypertension (PAH). We hypothesized that clonally selected ECs expressing the progenitor marker CD117 promote severe occlusive pulmonary hypertension (PH). The remodelled pulmonary arteries of PAH patients harboured CD117+ ECs. Rat lung CD117+ ECs underwent four generations of clonal expansion to enrich hyperproliferative ECs. The resulting clonally enriched ECs behaved like ECs, as measured by in vitro and in vivo angiogenesis assays. The same primitive ECs showed a limited ability for mesenchymal lineage differentiation. Endothelial differentiation and function were enhanced by blocking TGF-β signalling, promoting bone morphogenic protein (BMP) signalling. The transplantation of the EC clones caused arterio-occlusive PH in rats exposed to chronic hypoxia. These EC clones engrafted in the pulmonary arteries. Yet cessation of chronic hypoxia promoted lung cell apoptosis and resolution of vascular lesions. In conclusion, this is to the best of our knowledge, the first report that clonally enriched primitive ECs promote occlusive pulmonary arteriopathy and severe PH. These primitive EC clones further give rise to cells of endothelial and mesenchymal lineage as directed by BMP and TGF-β signaling.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bhagwani AR,Farkas D,Harmon B,Authelet KJ,Cool CD,Kolb M,Goncharova E,Yoder MC,Clauss M,Freishtat R,Farkas Ldoi
10.1038/s41598-020-58083-7subject
Has Abstractpub_date
2020-01-24 00:00:00pages
1136issue
1issn
2045-2322pii
10.1038/s41598-020-58083-7journal_volume
10pub_type
杂志文章abstract：:Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80614-5
更新日期：2021-01-13 00:00:00
abstract：:A central challenge in designing and administering effective anticoagulants is achieving the proper therapeutic window and dosage for each patient. The Hill coefficient, nH, which measures the steepness of a dose-response relationship, may be a useful gauge of this therapeutic window. We sought to measure the Hill coe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29387
更新日期：2016-07-21 00:00:00
abstract：:Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure pla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38542
更新日期：2016-12-07 00:00:00
abstract：:The Fenton-like activity of nanoceria has attracted intensive attention for wastewater treatment in recent years. During the Fenton-like reaction, the adsorption of organic pollutants on catalyst surface plays a key role in their degradation. In this work, the adsorption-degradation of methylene blue (MB) and Congo re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36794-2
更新日期：2019-03-21 00:00:00
abstract：:It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects. First, we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28849-1
更新日期：2018-07-13 00:00:00
abstract：:Upper urinary tract urothelial carcinomas are usually managed by radical nephroureterectomy (RNU), often followed by intravesical chemotherapy to minimize recurrence. Open surgery is the gold standard procedure for RNU, but it associates with high morbidity, and it has been increasingly replaced by minimally invasive ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54304-w
更新日期：2019-12-10 00:00:00
abstract：:Horseradish peroxidase (HRP) mediates efficient conversion of many phenolic contaminants and thus has potential applications for pollution control. Such potentially important applications suffer however from the fact that the enzyme becomes quickly inactivated during phenol oxidation and polymerization. The work here ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03126
更新日期：2013-11-04 00:00:00
abstract：:Pulse wave transit time (PWTT) has been widely used as an index in assessing arterial stiffness. Percutaneous coronary intervention (PCI) is usually applied to the treatment of coronary artery disease (CAD). Research on the changes in PWTT caused by PCI is helpful for understanding the impact of the PCI procedure. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18520-6
更新日期：2018-01-08 00:00:00
abstract：:Estuarine-coastal ecosystems are rich areas of the global ocean with elevated rates of organic matter production supporting major fisheries. Net and gross primary production (NPP, GPP) are essential properties of these ecosystems, characterized by high spatial, seasonal, and inter-annual variability associated with cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58702-3
更新日期：2020-02-06 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure. Symptomatic therapy has prolonged survival by limiting deaths resulting from respiratory insufficiency, but there is currently no effective therapy for most ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48744-7
更新日期：2019-08-23 00:00:00
abstract：:The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14205-2
更新日期：2017-11-02 00:00:00
abstract：:Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47564-z
更新日期：2019-08-05 00:00:00
abstract：:The study of organic/inorganic molecules with activity against intracellular fungi of the phylum Microsporidia is of critical importance. Here, for the first time, the inactivation of these parasitic fungi by porphyrins is reported. The biological effects of porphyrins (10 µM and 100 µM) on the microsporidian Nosema c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23678-8
更新日期：2018-04-03 00:00:00
abstract：:We perform a detailed theoretical and experimental investigation of supercontinuum generation in large-mode-area photonic crystal fibers pumped by a high-energy, high-repetition rate picosecond Nd:YVO4 laser, with the goal of using it as the Stokes beam in coherent anti-Stokes Raman scattering setup. We analyze the in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27811-5
更新日期：2018-06-22 00:00:00
abstract：:Inbreeding can depress individuals' fitness traits and reduce population viability. However, studies that directly translate inbreeding depression on fitness traits into consequences for population viability, and further, into consequences for management choices, are lacking. Here, we estimated impacts of inbreeding d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79979-4
更新日期：2021-01-12 00:00:00
abstract：:Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not yet been well studied...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58320-z
更新日期：2020-01-29 00:00:00
abstract：:Stress variation induced bandgap tuning and surface wettability switching of spinel nickel ferrite (NiFe2O4, NFO) films were demonstrated and directly driven by phase transition via a post-annealing process. Firstly, the as-deposited NFO films showed hydrophilic surface with water contact angle (CA) value of 80 ± 1°. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19319-9
更新日期：2018-01-22 00:00:00
abstract：:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37387-9
更新日期：2019-01-31 00:00:00
abstract：:Previous studies of protein fold space suggest that fold coverage is plateauing. However, sequence sampling has been -and remains to a large extent- heavily biased, focusing on culturable phyla. Sustained technological developments have fuelled the advent of metagenomics and single-cell sequencing, which might correct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14717
更新日期：2015-10-05 00:00:00
abstract：:The oral microbiota change dramatically with each part of the oral cavity, even within the same mouth. Nevertheless, the microbiota associated with peri-implantitis and periodontitis have been considered the same. To improve our knowledge of the different communities of complex oral microbiota, we compared the microbi...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep06602
更新日期：2014-10-13 00:00:00
abstract：:The 14-3-3-related protein SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD). Like 14-3-3, SMG7 engages phosphoserine-dependent protein interactions; however, the precise role of phosphorylation-mediated SMG7 binding remains unknown. Here, we show that DNA damage-ind...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49229-3
更新日期：2019-09-11 00:00:00
abstract：:Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33450-7
更新日期：2018-11-01 00:00:00
abstract：:Due to the lack of a proper imaging approach, a veracious pH map of normal and abnormal cell is still rare. In this work, we presented a rhodamine-salicylaldehyde combination (Rh-SA2) as a novel pH probe, which has dual sensitive units for both acidic and basic environment. This dual sensitive probe acts like a chamel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15540
更新日期：2015-10-21 00:00:00
abstract：:Knowing when, where, and how seizures are initiated in large-scale epileptic brain networks remains a widely unsolved problem. Seizure precursors - changes in brain dynamics predictive of an impending seizure - can now be identified well ahead of clinical manifestations, but either the seizure onset zone or remote bra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47092-w
更新日期：2019-07-23 00:00:00
abstract：:Thermoelectric effects in magnetic tunnel junctions are promising to serve as the basis for logic devices or memories in a "green" information technology. However, up to now the readout contrast achieved with Seebeck effects was magnitudes smaller compared to the well-established tunnel magnetoresistance effect. Here,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08945
更新日期：2015-03-10 00:00:00
abstract：:Because tetragonal structured MnGa alloy has intrinsic (not interface induced) giant perpendicular magnetic anisotropy (PMA), ultra-low damping constant and high spin polarization, it is predicted to be a kind of suitable magnetic electrode candidate in the perpendicular magnetic tunnel junction (p-MTJ) for high densi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43064
更新日期：2017-02-24 00:00:00
abstract：:Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52607-6
更新日期：2019-11-15 00:00:00
abstract：:The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30225-y
更新日期：2018-08-03 00:00:00
abstract：:Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50626-x
更新日期：2019-10-01 00:00:00
abstract：:The Hauraki Gulf, a shallow embayment in north-eastern New Zealand, provides an interesting environment for ecological soundscape research. It is situated on a tectonic plate boundary, contains one of the busiest ports in the southern hemisphere and is home to a diverse range of soniferous animals. The underwater soun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06347-0
更新日期：2017-07-18 00:00:00
