Abstract：
:Due to the lack of a proper imaging approach, a veracious pH map of normal and abnormal cell is still rare. In this work, we presented a rhodamine-salicylaldehyde combination (Rh-SA2) as a novel pH probe, which has dual sensitive units for both acidic and basic environment. This dual sensitive probe acts like a chameleon in living cells and offers the doubling guarantees for endocellular pH mapping. Moreover, a quantitative measurement of cellular pH changes was allowed and the endocellular pH values under drug-associated stimuli were also investigated.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yu KK,Hou JT,Li K,Yao Q,Yang J,Wu MY,Xie YM,Yu XQdoi
10.1038/srep15540subject
Has Abstractpub_date
2015-10-21 00:00:00pages
15540issn
2045-2322pii
srep15540journal_volume
5pub_type
杂志文章abstract：:Hfq is a bacterial RNA binding protein that carries out several roles in genetic expression regulation, mainly at the post-transcriptional level. Previous studies have shown its importance in growth and virulence of bacteria. Here, we provide the direct observation of its ability to interact with membranes. This was e...
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abstract：:Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. However, searching for mutually ex...
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-09-29 00:00:00
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更新日期：2014-12-15 00:00:00
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更新日期：2017-12-14 00:00:00
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journal_title：Scientific reports
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更新日期：2017-02-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-03-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-20 00:00:00
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更新日期：2017-09-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2021-01-11 00:00:00
