Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.

abstract：:Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...

journal_title：Scientific reports

authors： Vinding MC,Tsitsi P,Piitulainen H,Waldthaler J,Jousmäki V,Ingvar M,Svenningsson P,Lundqvist D

更新日期：2019-02-22 00:00:00

abstract：:Rather than the conventional concept of viewing conductive carbon black (CB) to be chemically inert in microbial electrochemical cells (MECs), here we confirmed the redox activity of CB for its feasibility as an electron sink in the microbial battery (MB). Acting as the cathode of a MB, the solid-state CB electrode sh...

journal_title：Scientific reports

authors： Zhang X,Guo K,Shen D,Feng H,Wang M,Zhou Y,Jia Y,Liang Y,Zhou M

更新日期：2017-08-01 00:00:00

abstract：:We demonstrate an experimental methodology for measuring the temporal distribution of pico-second level electron bunch with low energy using radial electric and azimuthal magnetic fields of an accelerating ([Formula: see text] mode) radio frequency (RF) cavity that is used for accelerating electron beams in a linear a...

journal_title：Scientific reports

authors： Hwang JG,Miyajima T,Honda Y,Kim ES

更新日期：2020-11-03 00:00:00

abstract：:Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly performed in resource-limited-settings due to technological challenges, high-costs, and lack of trained professionals. We demonstrate an automated and cost-effec...

journal_title：Scientific reports

authors： Feng S,Tseng D,Di Carlo D,Garner OB,Ozcan A

更新日期：2016-12-15 00:00:00

abstract：:CCN2/Connective tissue growth factor seems to be involved in development of cardiac hypertrophy and fibrosis, but a possible cardioprotective role in left ventricular (LV) remodelling following myocardial infarction has also been suggested. The main objectives of the study were therefore to investigate whether circula...

journal_title：Scientific reports

authors： Ritschel V,Shetelig C,Seljeflot I,Limalanathan S,Hoffmann P,Halvorsen S,Arnesen H,Eritsland J,Andersen GØ

更新日期：2017-09-20 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis (TB) and induces highly variable protection against pulmonary disease in different countries. We hypothesised that DNA methylation is one of the molecular mechanisms driving variability in BCG-induced immune responses. DNA methylation in peri...

journal_title：Scientific reports

authors： Hasso-Agopsowicz M,Scriba TJ,Hanekom WA,Dockrell HM,Smith SG

更新日期：2018-08-30 00:00:00

abstract：:The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...

journal_title：Scientific reports

authors： Harrison C,Binetti N,Mareschal I,Johnston A

更新日期：2018-06-13 00:00:00

abstract：:Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...

journal_title：Scientific reports

authors： Jin L,Sun S,Ryu Y,Piao ZH,Liu B,Choi SY,Kim GR,Kim HS,Kee HJ,Jeong MH

更新日期：2018-06-18 00:00:00

abstract：:Nociceptive neurons play an essential role in pain sensation by transmitting painful stimuli to the central nervous system. However, investigations of nociceptive neuron biology have been hampered by the lack of accessibility of human nociceptive neurons. Here, we describe a system for efficiently guiding human embryo...

journal_title：Scientific reports

authors： Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ

更新日期：2015-11-19 00:00:00

abstract：:Bony defects are a common problem in musculoskeletal surgery. Replacement with autologous bone grafts is limited by availability of transplant material. Sterilized cancellous bone, while being osteoconductive, has limited osteoinductivity. Nanofiber scaffolds are currently used for several purposes due to their capabi...

journal_title：Scientific reports

authors： Schüttler KF,Bauhofer MW,Ketter V,Giese K,Eschbach DA,Yenigün M,Fuchs-Winkelmann S,Paletta JRJ

更新日期：2020-06-12 00:00:00

abstract：:In swine the upper reproductive tract undergoes early postnatal development, however little is known about the lower reproductive tract. Our objective was to measure cytology and proteome of vaginal swab samples taken on postnatal day (PND) 2 and 16 in gilts to determine if temporal changes occurred in cell and protei...

journal_title：Scientific reports

authors： Harlow K,Suarez-Trujillo A,Hedrick V,Sobreira T,Aryal UK,Stewart K,Casey T

更新日期：2019-09-13 00:00:00

abstract：:Plant species of the genus Cecropia (Urticaceae) are used as traditional medicine in Latin-America, and are commercially available as food supplements. The aim of this study was to characterize and compare the phytochemical constituents of four Cecropia species collected in Panama. The structures of 11 compounds isola...

journal_title：Scientific reports

authors： Rivera-Mondragón A,Bijttebier S,Tuenter E,Custers D,Ortíz OO,Pieters L,Caballero-George C,Apers S,Foubert K

更新日期：2019-02-11 00:00:00

abstract：:During folliculogenesis, primary oocytes of teleosts grow by several orders of magnitude by-self synthesizing proteins and mRNA, or sequestering from blood specific macromolecular components, such as fatty acids and vitellogenin. All these materials are stored into cortical alveoli, yolk globules or oil droplets durin...

journal_title：Scientific reports

authors： Carnevali O,Candelma M,Sagrati A,Pignalosa P,Giorgini E,Gioacchini G

更新日期：2019-06-20 00:00:00

abstract：:Accurate measurements of autonomic nerve regulation in heart failure (HF) were unresolved. The discriminating performance of deceleration and acceleration capacities of heart rate in HF was evaluated in 130 HF patients and 212 controls. Acceleration capacity and deceleration capacity were independent risk factors for ...

journal_title：Scientific reports

authors： Hu W,Jin X,Zhang P,Yu Q,Yin G,Lu Y,Xiao H,Chen Y,Zhang D

更新日期：2016-03-23 00:00:00

abstract：:Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...

journal_title：Scientific reports

authors： Andriukonis E,Gorokhova E

更新日期：2017-03-10 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:In our previous study, a liver-targeting peptide CSP I-plus modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed and showed potent antiangiogenic capability and could specifically bind to human hepatocellular carcinoma cells to make a direct inhibition in vitro. In this study, the bi...

journal_title：Scientific reports

authors： Yan M,Dongmei B,Jingjing Z,Xiaobao J,Jie W,Yan W,Jiayong Z

更新日期：2017-10-26 00:00:00

abstract：:Propionibacterium acnes (P. acnes) is a major skin-associated bacterium that was long considered commensal, until several studies revealed it to be an opportunistic pathogen. We investigated the ability of P. acnes surface proteins to recognize ECM proteins and showed that a 58 kDa P. acnes surface protein was specifi...

journal_title：Scientific reports

authors： Grange PA,Raingeaud J,Morelle W,Marcelin AG,Calvez V,Dupin N

更新日期：2017-07-25 00:00:00

abstract：:Probing the oligomeric state of abundant molecules, such as membrane proteins in intact cells, is essential, but has not been straightforward. We address this challenge with a simple counting strategy that is capable of reporting the oligomeric state of dense, membrane-bound protein complexes. It is based on single-mo...

journal_title：Scientific reports

authors： Fricke F,Beaudouin J,Eils R,Heilemann M

更新日期：2015-09-11 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Dahan A,Reiner M

更新日期：2018-04-24 00:00:00

abstract：:The myxozoan parasite, Tetracapsuloides bryosalmonae has a two-host life cycle alternating between freshwater bryozoans and salmonid fish. Infected fish can develop Proliferative Kidney Disease, characterised by a gross lymphoid-driven kidney pathology in wild and farmed salmonids. To facilitate an in-depth understand...

journal_title：Scientific reports

authors： Faber M,Shaw S,Yoon S,de Paiva Alves E,Wang B,Qi Z,Okamura B,Hartikainen H,Secombes CJ,Holland JW

更新日期：2021-01-25 00:00:00

abstract：:Magnetic materials have found wide application ranging from electronics and memories to medicine. Essential to these advances is the control of the magnetic order. To date, most room-temperature applications have a fixed magnetic moment whose orientation is manipulated for functionality. Here we demonstrate an iron-ox...

journal_title：Scientific reports

authors： Lin AL,Rodrigues JN,Su C,Milletari M,Loh KP,Wu T,Chen W,Neto AH,Adam S,Wee AT

更新日期：2015-06-23 00:00:00

abstract：:Colletotrichum infects diverse hosts, including tea plants, and can lead to crop failure. Numerous studies have reported that biological processes are involved in the resistance of tea plants to Colletotrichum spp. However, the molecular and biochemical responses in the host during this interaction are unclear. Cuttin...

journal_title：Scientific reports

authors： Lu Q,Wang Y,Xiong F,Hao X,Zhang X,Li N,Wang L,Zeng J,Yang Y,Wang X

更新日期：2020-07-30 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson's disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, we addressed the impact of aSyn specifically on mitochondrial response to OS in ...

journal_title：Scientific reports

authors： Menges S,Minakaki G,Schaefer PM,Meixner H,Prots I,Schlötzer-Schrehardt U,Friedland K,Winner B,Outeiro TF,Winklhofer KF,von Arnim CA,Xiang W,Winkler J,Klucken J

更新日期：2017-02-22 00:00:00

abstract：:Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...

journal_title：Scientific reports

authors： Kim J,Aydemir TB,Jimenez-Rondan FR,Ruggiero CH,Kim MH,Cousins RJ

更新日期：2020-03-04 00:00:00

abstract：:Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...

journal_title：Scientific reports

authors： He F,Agosto MA,Anastassov IA,Tse DY,Wu SM,Wensel TG

更新日期：2016-06-01 00:00:00

abstract：:Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...

journal_title：Scientific reports

authors： Choi J,Yoon YN,Kim N,Park CS,Seol H,Park IC,Kim HA,Noh WC,Kim JS,Seong MK

更新日期：2020-01-20 00:00:00

abstract：:Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated...

journal_title：Scientific reports

authors： Lacerda-Queiroz N,Riteau N,Eastman RT,Bock KW,Orandle MS,Moore IN,Sher A,Long CA,Jankovic D,Su XZ

更新日期：2017-09-05 00:00:00

abstract：:Insects' exoskeleton, gut, hemocoel, and cells are colonized by various microorganisms that often play important roles in their host life. Moreover, insects are frequently infected by vertically transmitted symbionts that can manipulate their reproduction. The aims of this study were the characterization of bacterial ...

journal_title：Scientific reports

authors： Kaczmarczyk A,Kucharczyk H,Kucharczyk M,Kapusta P,Sell J,Zielińska S

更新日期：2018-09-26 00:00:00