Simple oral mucosal epithelial transplantation in a rabbit model.

abstract：:An unresolved mystery in the field of spinal muscular atrophy (SMA) is why a reduction of the ubiquitously expressed Smn protein causes defects mostly in motoneurons. We addressed the possibility that this restricted vulnerability stems from elevated Smn expression in motoneurons. To explore this, we established an ex...

journal_title：Scientific reports

authors： Spiró Z,Koh A,Tay S,See K,Winkler C

更新日期：2016-06-07 00:00:00

abstract：:Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also challenging. We presen...

journal_title：Scientific reports

authors： Beaudet MJ,Yang Q,Cadau S,Blais M,Bellenfant S,Gros-Louis F,Berthod F

更新日期：2015-11-18 00:00:00

abstract：:Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...

journal_title：Scientific reports

authors： Hidalgo D,Georgiev M,Marchev A,Bru-Martínez R,Cusido RM,Corchete P,Palazon J

更新日期：2017-12-21 00:00:00

abstract：:PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutama...

journal_title：Scientific reports

authors： Xu J,Wang N,Luo JH,Xia J

更新日期：2016-02-12 00:00:00

abstract：:High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigene...

journal_title：Scientific reports

authors： Hu M,Qu X,Pan L,Fu C,Jia P,Liu Q,Wang Y

更新日期：2017-09-05 00:00:00

abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...

journal_title：Scientific reports

authors： Koblischke M,Mackroth MS,Schwaiger J,Fae I,Fischer G,Stiasny K,Heinz FX,Aberle JH

更新日期：2017-08-21 00:00:00

abstract：:Nitrogen fixation is essential for the synthesis of many important chemicals (e.g., fertilizers, explosives) and basic building blocks for all forms of life (e.g., nucleotides for DNA and RNA, amino acids for proteins). However, direct nitrogen fixation is challenging as nitrogen (N₂) does not easily react with other ...

journal_title：Scientific reports

authors： Jeon IY,Choi HJ,Ju MJ,Choi IT,Lim K,Ko J,Kim HK,Kim JC,Lee JJ,Shin D,Jung SM,Seo JM,Kim MJ,Park N,Dai L,Baek JB

更新日期：2013-01-01 00:00:00

abstract：:Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapmer drugs, a deeper ...

journal_title：Scientific reports

authors： Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A

更新日期：2016-07-27 00:00:00

abstract：:In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate was 29.9%. In the p53-negative group, median disease free survival (DFS), and time from primary breast cancer diagnosis to death (OS1), time f...

journal_title：Scientific reports

authors： Yang P,Du CW,Kwan M,Liang SX,Zhang GJ

更新日期：2013-01-01 00:00:00

abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

journal_title：Scientific reports

authors： Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

更新日期：2016-02-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wang Y,Lan W,Yan Z,Gao J,Liu X,Wang S,Guo X,Wang C,Zhou H,Ding J,Cao C

更新日期：2020-02-26 00:00:00

abstract：:We demonstrate the application of whole exome sequencing to discover the rare variants for congenital pouch colon, acronymed CPC. For 18 affected individuals in a total of 64 samples, we sequenced coding regions to a mean coverage of 100×. A sufficient depth of ca. 94% of targeted exomes was achieved. Filtering agains...

journal_title：Scientific reports

authors： Mathur P,Medicherla KM,Chaudhary S,Patel M,Bagali P,Suravajhala P

更新日期：2018-04-27 00:00:00

abstract：:One of the key motivations in producing 3D structures has always been the realization of metamaterials with effective constituent properties that can be tuned in all propagation directions at various frequencies. Here, we report the investigation of spatially oriented "Nanograter" structures with orientation-dependent...

journal_title：Scientific reports

authors： Liu Z,Cui A,Gong Z,Li H,Xia X,Shen TH,Li J,Yang H,Li W,Gu C

更新日期：2016-06-30 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Colizoli O,de Gee JW,Urai AE,Donner TH

更新日期：2018-10-23 00:00:00

abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...

journal_title：Scientific reports

authors： Kim H,Lee W,Park S,Kyhm K,Je K,Taylor RA,Nogues G,Dang LS,Song JD

更新日期：2017-01-05 00:00:00

abstract：:Detailed measurement of cell phenotype information from digital fluorescence images has the potential to greatly advance biomedicine in various disciplines such as patient diagnostics or drug screening. Yet, the complexity of cell conformations presents a major barrier preventing effective determination of cell bounda...

journal_title：Scientific reports

authors： Arce SH,Wu PH,Tseng Y

更新日期：2013-01-01 00:00:00

abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...

journal_title：Scientific reports

authors： Morshed MN,Pervez MN,Behary N,Bouazizi N,Guan J,Nierstrasz VA

更新日期：2020-09-30 00:00:00

abstract：:Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific biodistribution. Nanoparticle based delivery systems are being evaluated to overcome these lim...

journal_title：Scientific reports

authors： Choi WI,Sahu A,Vilos C,Kamaly N,Jo SM,Lee JH,Tae G

更新日期：2017-10-30 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00

abstract：:Halophilic proteins subjected to below about 15% salt in vitro denature through misfolding, aggregation and/or precipitation. Halobacteria, however, have been detected in environments of fluctuating salinity such as coastal salterns and even around fresh water springs in the depths of the Dead Sea. In order to identif...

journal_title：Scientific reports

authors： Vauclare P,Natali F,Kleman JP,Zaccai G,Franzetti B

更新日期：2020-02-24 00:00:00

abstract：:Thaumatin is an intensely sweet-tasting protein that elicits sweet taste at a concentration of 50 nM, a value 100,000 times larger than that of sucrose on a molar basis. Here we attempted to produce a protein with enhanced sweetness by removing negative charges on the interacting side of thaumatin with the taste recep...

journal_title：Scientific reports

authors： Masuda T,Ohta K,Ojiro N,Murata K,Mikami B,Tani F,Temussi PA,Kitabatake N

更新日期：2016-02-03 00:00:00

abstract：:We present axial plane optical microscopy (APOM) that can, in contrast to conventional microscopy, directly image a sample's cross-section parallel to the optical axis of an objective lens without scanning. APOM combined with conventional microscopy simultaneously provides two orthogonal images of a 3D sample. More im...

journal_title：Scientific reports

authors： Li T,Ota S,Kim J,Wong ZJ,Wang Y,Yin X,Zhang X

更新日期：2014-12-01 00:00:00

abstract：:Ras mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an artificial cyclic peptide, KRpep-2d, was discovered as the first selective inhibi...

journal_title：Scientific reports

authors： Sakamoto K,Masutani T,Hirokawa T

更新日期：2020-12-10 00:00:00

abstract：:Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli p...

journal_title：Scientific reports

authors： Christofi T,Panayidou S,Dieronitou I,Michael C,Apidianakis Y

更新日期：2019-10-08 00:00:00

abstract：:We tested the hypothesis that modulation of neurocomputational inputs to value-based decision-making affects the rationality of economic choices. The brain's right temporoparietal junction (rTPJ) has been functionally associated with both social behavior and with domain-general information processing and attention. To...

journal_title：Scientific reports

authors： Li F,Ball S,Zhang X,Smith A

更新日期：2020-11-20 00:00:00

abstract：:Graphene has been identified as an emerging horizon for a nanoscale photonic platform because the Fermi level of intrinsic graphene can be engineered to support surface plasmons (SPs). The current solid back electrical gating and chemical doping methods cannot facilitate the demonstration of graphene SPs at the near-i...

journal_title：Scientific reports

authors： Zhang Q,Li X,Hossain MM,Xue Y,Zhang J,Song J,Liu J,Turner MD,Fan S,Bao Q,Gu M

更新日期：2014-10-09 00:00:00

abstract：:Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis t...

journal_title：Scientific reports

authors： Swales JG,Strittmatter N,Tucker JW,Clench MR,Webborn PJH,Goodwin RJA

更新日期：2016-11-24 00:00:00

abstract：:Mountain ecosystems serve as sentinels of change, and those in the Canadian Rocky Mountains have undergone a pronounced shift over the past century. We present quantitative analyses of 81 high-resolution image pairs of systematic historic surveys and repeat photographs of Canadian Rocky Mountain habitats, measuring tr...

journal_title：Scientific reports

authors： Trant A,Higgs E,Starzomski BM

更新日期：2020-06-16 00:00:00

abstract：:Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little und...

journal_title：Scientific reports

authors： Murphy EJ,Thorpe SE,Tarling GA,Watkins JL,Fielding S,Underwood P

更新日期：2017-07-31 00:00:00

abstract：:Amorphous thin films from Ge-As-Te system were prepared by pulsed laser deposition to study their intrinsic photostability, morphology, chemical composition, structure and optical properties. Photostability of fabricated layers was studied by spectroscopic ellipsometry within as-deposited as well as relaxed (annealed)...

journal_title：Scientific reports

authors： Hawlová P,Verger F,Nazabal V,Boidin R,Němec P

更新日期：2015-03-23 00:00:00