Abstract:
:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using carefully-engineered image features from magnetic resonance images (MRI). However, feature engineering is usually time consuming, laborious and subjective. Most importantly, the engineered features cannot effectively encode other predictive but implicit information provided by multi-modal neuroimages. We propose a two-stage learning-based method to predict the overall survival (OS) time of high-grade gliomas patient. At the first stage, we adopt deep learning, a recently dominant technique of artificial intelligence, to automatically extract implicit and high-level features from multi-modal, multi-channel preoperative MRI such that the features are competent of predicting survival time. Specifically, we utilize not only contrast-enhanced T1 MRI, but also diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI), for computing multiple metric maps (including various diffusivity metric maps derived from DTI, and also the frequency-specific brain fluctuation amplitude maps and local functional connectivity anisotropy-related metric maps derived from rs-fMRI) from 68 high-grade glioma patients with different survival time. We propose a multi-channel architecture of 3D convolutional neural networks (CNNs) for deep learning upon those metric maps, from which high-level predictive features are extracted for each individual patch of these maps. At the second stage, those deeply learned features along with the pivotal limited demographic and tumor-related features (such as age, tumor size and histological type) are fed into a support vector machine (SVM) to generate the final prediction result (i.e., long or short overall survival time). The experimental results demonstrate that this multi-model, multi-channel deep survival prediction framework achieves an accuracy of 90.66%, outperforming all the competing methods. This study indicates highly demanded effectiveness on prognosis of deep learning technique in neuro-oncological applications for better individualized treatment planning towards precision medicine.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nie D,Lu J,Zhang H,Adeli E,Wang J,Yu Z,Liu L,Wang Q,Wu J,Shen Ddoi
10.1038/s41598-018-37387-9subject
Has Abstractpub_date
2019-01-31 00:00:00pages
1103issue
1issn
2045-2322pii
10.1038/s41598-018-37387-9journal_volume
9pub_type
杂志文章abstract::Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fouri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33141
更新日期:2016-09-14 00:00:00
abstract::Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08635
更新日期:2015-03-02 00:00:00
abstract::A series of nanocomposites of cobalt embedded in N-doped nanoporous carbons, carbon nanotubes or hollow carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67. The effect of the carbonization temperature on the structural evolution of the resulting nanocomposites has been inv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05636-y
更新日期:2017-07-13 00:00:00
abstract::We discovered a technical solution of such outstanding importance that it can trigger new approaches in silicon wet etching processing and, in particular, photovoltaic cell manufacturing. The so called inverted pyramid arrays, outperforming conventional pyramid textures and black silicon because of their superior ligh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10843
更新日期:2015-06-02 00:00:00
abstract::The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30431-8
更新日期:2018-08-17 00:00:00
abstract::We report the counterintuitive mechanism of increasing boiling heat transfer by incorporating low-conductivity materials at the interface between the surface and fluid. By embedding an array of non-conductive lines into a high-conductivity substrate, in-plane variations in the local surface temperature are created. Du...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13145
更新日期:2015-08-18 00:00:00
abstract::Sensitive in situ detection of organic molecules is highly demanded in environmental monitoring. In this work, the surface enhanced Raman spectroscopy (SERS) is adopted in microfluidics to detect the organic molecules with high accuracy and high sensitivity. Here the SERS substrate in microchannel consists of Ag nanop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53478-7
更新日期:2019-11-27 00:00:00
abstract::Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In recent years a surge of evidence has suggested that the gut micr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35455
更新日期:2016-10-18 00:00:00
abstract::In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35021-2
更新日期:2018-11-09 00:00:00
abstract::Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28281
更新日期:2016-09-06 00:00:00
abstract::Direct measures of energy expenditure are difficult to obtain in marine mammals, and accelerometry may be a useful proxy. Recently its utility has been questioned as some analyses derived their measure of activity level by calculating the sum of accelerometry-based values and then comparing this summation to summed (t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11576-4
更新日期:2017-09-18 00:00:00
abstract::Mechanochemical synthesis of Si/Cu3Si-based composite as negative electrode materials for lithium ion battery is investigated. Results indicate that CuO is decomposed and alloyed with Si forming amorphous Cu-Si solid solution due to high energy impacting during high energy mechanical milling (HEMM). Upon carbonization...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30703-3
更新日期:2018-08-23 00:00:00
abstract::The detection of pruritic (itchy) stimuli is mediated by a variety of receptors and channels expressed by primary sensory neurons. The G protein-coupled receptor (GPCR) MRGPRD is selectively expressed by a subset of mouse non-peptidergic nociceptors and functions as the molecular receptor for the itch-inducing chemica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12770-0
更新日期:2017-10-24 00:00:00
abstract::The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21197
更新日期:2016-02-18 00:00:00
abstract::Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02618-y
更新日期:2017-05-26 00:00:00
abstract::GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl-] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models. However, the tem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00196-7
更新日期:2017-03-13 00:00:00
abstract::The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective of time series analysis. In the current study, we used a distributed lag nonlinear model (DLNM) to analyze a 10-year series of consecutive surveillance data. We found that, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28426-6
更新日期:2018-07-03 00:00:00
abstract::The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04526
更新日期:2014-03-31 00:00:00
abstract::Remote earthquake triggering is a well-established phenomenon. Triggering is commonly identified from statistically significant increases in earthquake rate coincident with the passage of seismic energy. In establishing rate changes, short duration earthquake catalogs are commonly used, and triggered sequences are not...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60988-2
更新日期:2020-03-05 00:00:00
abstract::Prognostic biomarkers for the pancreatic neuroendocrine tumors are needed. Proteomic study on insulinoma has been rarely reported. We identified the differential expression of proteins between insulinoma and their paired tissues by proteomic analysis, and evaluated the prognostic significance of specific proteins in p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02051-1
更新日期:2017-05-19 00:00:00
abstract::Two-dimensional (2D) porous carbon AC-SPN-3 possessing of amazing high micropore volume ratio of 83% and large surface area of about 1069 m(2) g(-1) is high-yield obtained by pyrolysis of natural waste Pistachio nutshells with KOH activation. The AC-SPN-3 has a curved 2D lamellar morphology with the thickness of each ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05545
更新日期:2014-07-02 00:00:00
abstract::In this population-based retrospective study, we aimed to investigate the association between age at diagnosis and prognosis of pancreatic cancer (PC) patients using data from the National Cancer Institute's Surveillance, Epidemiology, and the End Results database. Different factors for stratification, like race, sex,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64068-3
更新日期:2020-04-27 00:00:00
abstract::The compound Sr0.5Ce0.5FBiS2 belongs to the intensively studied family of layered BiS2 superconductors. It attracts special attention because superconductivity at T sc = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C = 7.5 K. Recently it was reported that upon replacing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17637-y
更新日期:2017-12-12 00:00:00
abstract::γ-Oryzanol (OZ), which has a lot of beneficial effects, is a mixture of ferulic acid esters of triterpene alcohols (i.e., triterpene alcohol type of OZ (TTA-OZ)) and ferulic acid esters of plant sterols (i.e., plant sterol type of OZ (PS-OZ)). Although it has been reported that OZ is found in several kinds of cereal t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48985-6
更新日期:2019-08-29 00:00:00
abstract::Stability and integration are the goals for developing photonic devices. Spirooxazines have the property of photoinduced merocyanine-aggregation in polymer matrix, which can be applied to fluorescence emission and stable information storage. Although visible light coherent radiation with UV-assist has been used to ach...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22202-2
更新日期:2018-02-28 00:00:00
abstract::Upper mantle viscosity plays a key role in understanding plate tectonics and is usually extrapolated from laboratory-based creep measurements of upper mantle conditions or constrained by modeling geodetic and post-seismic observations. At present, an effective method to obtain a high-resolution viscosity structure is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20250-2
更新日期:2018-01-29 00:00:00
abstract::Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and neuronal ceroid lipofuscinosis (NCLs). However, the reasons why syna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12603-0
更新日期:2017-09-29 00:00:00
abstract::We demonstrate synthesis of Ni/CuOx/Ni nanowires (NWs) by electrochemical deposition on anodized aluminum oxide (AAO) membranes. AAO with pore diameter of ~70 nm and pore length of ~50 μm was used as the template for synthesis of NWs. After deposition of Au as the seed layer, NWs with a structure of Ni/CuOx/Ni were gr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23069
更新日期:2016-03-15 00:00:00
abstract::On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13315-1
更新日期:2017-11-06 00:00:00
abstract::Different subtypes of bone marrow-derived stem cells are characterized by varying functionality and activity after transplantation into the infarcted heart. Improvement of stem cell therapeutics requires deep knowledge about the mechanisms that mediate the benefits of stem cell treatment. Here, we demonstrated that co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10122-6
更新日期:2017-08-29 00:00:00