当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus.

Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus.

Abstract：

:Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we utilize a gene expression tracer allele of Shh (Shh-nlacZ) which allowed the identification of a subpopulation of hilar neurons known as mossy cells (MCs) as a prominent and dynamic source of Shh within the dentate gyrus. AAV-Cre mediated ablation of Shh in the adult dentate gyrus led to a marked degeneration of MCs. Conversely, chemical stimulation of hippocampal neurons using the epileptogenic agent kainic acid (KA) increased the number of Shh+ MCs indicating that the expression of Shh by MCs confers a survival advantage during the response to excitotoxic insults. In addition, ablation of Shh in the adult dentate gyrus led to increased neural precursor cell proliferation and their migration into the subgranular cell layer demonstrating that MCs-generated Shh is a key modulator of hippocampal neurogenesis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Gonzalez-Reyes LE,Chiang CC,Zhang M,Johnson J,Arrillaga-Tamez M,Couturier NH,Reddy N,Starikov L,Capadona JR,Kottmann AH,Durand DM

doi

10.1038/s41598-019-53192-4

subject

Has Abstract

pub_date

2019-11-22 00:00:00

pages

17402

issue

1

issn

2045-2322

pii

10.1038/s41598-019-53192-4

journal_volume

9

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma.

    abstract：:Glial cells actively maintain the homeostasis of brain parenchyma, regulating neuronal excitability and preserving the physiological composition of the extracellular milieu. Under pathological conditions, some functions of glial cells could be compromised, exacerbating the neurotoxic processes. We investigated if the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25940-5

    authors： Grimaldi A,D'Alessandro G,Di Castro MA,Lauro C,Singh V,Pagani F,Sforna L,Grassi F,Di Angelantonio S,Catacuzzeno L,Wulff H,Limatola C,Catalano M

    更新日期：2018-05-16 00:00:00

  • Tailoring Mechanically Robust Poly(m-phenylene isophthalamide) Nanofiber/nets for Ultrathin High-Efficiency Air Filter.

    abstract：:Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40550

    authors： Zhang S,Liu H,Yin X,Li Z,Yu J,Ding B

    更新日期：2017-01-11 00:00:00

  • Analysis of the metabolome of Anopheles gambiae mosquito after exposure to Mycobacterium ulcerans.

    abstract：:Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09242

    authors： Hoxmeier JC,Thompson BD,Broeckling CD,Small P,Foy BD,Prenni J,Dobos KM

    更新日期：2015-03-18 00:00:00

  • A Mediterranean mesophotic coral reef built by non-symbiotic scleractinians.

    abstract：:This is the first description of a Mediterranean mesophotic coral reef. The bioconstruction extended for 2.5 km along the Italian Adriatic coast in the bathymetric range -30/-55 m. It appeared as a framework of coral blocks mostly built by two scleractinians, Phyllangia americana mouchezii (Lacaze-Duthiers, 1897) and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40284-4

    authors： Corriero G,Pierri C,Mercurio M,Nonnis Marzano C,Onen Tarantini S,Gravina MF,Lisco S,Moretti M,De Giosa F,Valenzano E,Giangrande A,Mastrodonato M,Longo C,Cardone F

    更新日期：2019-03-05 00:00:00

  • High resolution low kV EBSD of heavily deformed and nanocrystalline Aluminium by dictionary-based indexing.

    abstract：:We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29315-8

    authors： Singh S,Guo Y,Winiarski B,Burnett TL,Withers PJ,De Graef M

    更新日期：2018-07-20 00:00:00

  • miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-β/SMAD signaling pathway.

    abstract：:EndMT has an important effect on metastasis and progression of tumor. This work will elucidate the effect of miR-494 on EndMT and development of HCC. Therefore, the differential miRNA expression among non-tumorous, para-tumorous and tumorous tissues was analyzed. Moreover, luciferase activities of SIRT3 3'UTR treated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43731-4

    authors： Zhang J,Zhu Y,Hu L,Yan F,Chen J

    更新日期：2019-05-10 00:00:00

  • Bacterial abundance and diversity in pond water supplied with different feeds.

    abstract：:The abundance and diversity of bacteria in two types of ponds were investigated by quantitative PCR and Illumina MiSeq sequencing. The results revealed that the abundance of bacterial 16S rRNA genes in D ponds (with grass carp fed sudan grass) was significantly lower than that in E ponds (with grass carp fed commercia...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35232

    authors： Qin Y,Hou J,Deng M,Liu Q,Wu C,Ji Y,He X

    更新日期：2016-10-19 00:00:00

  • ADP-dependent glucokinase as a novel onco-target for haematological malignancies.

    abstract：:Warburg effect or aerobic glycolysis provides selective growth advantage to aggressive cancers. However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude of cells. In this study, we present ADP-dependent glucokinase (ADPGK)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70014-0

    authors： Tandon A,Birkenhagen J,Nagalla D,Kölker S,Sauer SW

    更新日期：2020-08-12 00:00:00

  • Mechanical Nano-Patterning: Toward Highly-Aligned Ge Self-Assembly on Low Lattice Mismatched GaAs Substrate.

    abstract：:Low-dimensional semiconductor structurers formed on a substrate surface at pre-defined locations and with nano-precision placement is of vital interest. The potential of tailoring their electrical and optical properties will revolutionize the next generation of optoelectronic devices. Traditionally, highly aligned sel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50633-y

    authors： Dushaq G,Rasras M

    更新日期：2019-10-02 00:00:00

  • Virtual Planning, Control, and Machining for a Modular-Based Automated Factory Operation in an Augmented Reality Environment.

    abstract：:This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27380

    authors： Pai YS,Yap HJ,Md Dawal SZ,Ramesh S,Phoon SY

    更新日期：2016-06-07 00:00:00

  • Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.

    abstract：:Recent studies demonstrate that the invasion and metastasis of gastric cancer (GC) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase). Here we investigated the expression and role of the human ATP6V1A gene that encodes the catalytic subunit A of V-ATPase in GC. We found that ATP6V1A expression le...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03021-3

    authors： Wang P,Wang L,Sha J,Lou G,Lu N,Hang B,Mao JH,Zou X

    更新日期：2017-06-07 00:00:00

  • Green tide development associated with submarine groundwater discharge in a coastal harbor, Jeju, Korea.

    abstract：:We measured the magnitude of submarine fresh groundwater discharge (SFGD) and associated nutrient inputs to Jocheon harbor, on Jeju Island, Korea, during four sampling periods, in order to determine the link between SFGD and Ulva sp. green tide development. Good correlations among salinity, 222Rn, and dissolved inorga...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06711-0

    authors： Kwon HK,Kang H,Oh YH,Park SR,Kim G

    更新日期：2017-07-24 00:00:00

  • Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos.

    abstract：:CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of genome editing, phenotyp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71412-0

    authors： Naert T,Tulkens D,Edwards NA,Carron M,Shaidani NI,Wlizla M,Boel A,Demuynck S,Horb ME,Coucke P,Willaert A,Zorn AM,Vleminckx K

    更新日期：2020-09-04 00:00:00

  • Author Correction: Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-28390-1

    authors： Krukowski K,Feng X,Paladini MS,Chou A,Sacramento K,Grue K,Riparip LK,Jones T,Campbell-Beachler M,Nelson G,Rosi S

    更新日期：2018-07-03 00:00:00

  • Environmental filtering triggers community assembly of forest understorey plants in Central European pine stands.

    abstract：:Habitat filtering models predict ecologically similar plant species to jointly colonize sites due to comparable environmental characteristics leading to an aggregated pattern of species spatial occurrence. Models focused on interspecific competition expect species with similar ecological requirements to be spatially s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00255-z

    authors： Ulrich W,Sewerniak P,Puchałka R,Piwczyński M

    更新日期：2017-03-21 00:00:00

  • Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain.

    abstract：:Neural responses to incentives are altered in chronic pain and by opioid use. To understand how opioid use modulates the neural response to reward/value in chronic pain, we compared brain functional magnetic resonance imaging (fMRI) responses to a monetary incentive delay (MID) task in patients with fibromyalgia takin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45961-y

    authors： Martucci KT,MacNiven KH,Borg N,Knutson B,Mackey SC

    更新日期：2019-07-03 00:00:00

  • Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area.

    abstract：:Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems. Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin. Chitin, the second most ample polymer next to cellulose, is i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68772-y

    authors： Subramanian K,Sadaiappan B,Aruni W,Kumarappan A,Thirunavukarasu R,Srinivasan GP,Bharathi S,Nainangu P,Renuga PS,Elamaran A,Balaraman D,Subramanian M

    更新日期：2020-07-17 00:00:00

  • Author Correction: Evaluation of in vitro and in vivo antibiotic efficacy against a novel bioluminescent Shigella flexneri.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59766-x

    authors： McCloskey MC,Shaheen S,Rabago L,Hulverson MA,Choi R,Barrett LK,Arnold SLM

    更新日期：2020-02-11 00:00:00

  • Predicting mammalian species at risk of being infected by SARS-CoV-2 from an ACE2 perspective.

    abstract：:SARS-CoV-2 can transmit efficiently in humans, but it is less clear which other mammals are at risk of being infected. SARS-CoV-2 encodes a Spike (S) protein that binds to human ACE2 receptor to mediate cell entry. A species with a human-like ACE2 receptor could therefore be at risk of being infected by SARS-CoV-2. We...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80573-x

    authors： Wei Y,Aris P,Farookhi H,Xia X

    更新日期：2021-01-18 00:00:00

  • The oasis effect and summer temperature rise in arid regions - case study in Tarim Basin.

    abstract：:This study revealed the influence of the oasis effect on summer temperatures based on MODIS Land Surface Temperature (LST) and meteorological data. The results showed that the oasis effect occurs primarily in the summer. For a single oasis, the maximum oasis cold island intensity based on LST (OCILST) was 3.82 °C and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35418

    authors： Hao X,Li W,Deng H

    更新日期：2016-10-14 00:00:00

  • Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.

    abstract：:Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to alterations in glutamate levels. Despite the well-documented eff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80917-7

    authors： Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J

    更新日期：2021-01-14 00:00:00

  • Two-Dimensional Brain Microtubule Structures Behave as Memristive Devices.

    abstract：:Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48677-1

    authors： Cantero MDR,Perez PL,Scarinci N,Cantiello HF

    更新日期：2019-08-27 00:00:00

  • Publisher Correction: Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene-gene interactions.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-017-16210-x

    authors： Yang CH,Chuang LY,Lin YD

    更新日期：2017-11-23 00:00:00

  • Pulse-Wave-Pattern Classification with a Convolutional Neural Network.

    abstract：:Owing to the diversity of pulse-wave morphology, pulse-based diagnosis is difficult, especially pulse-wave-pattern classification (PWPC). A powerful method for PWPC is a convolutional neural network (CNN). It outperforms conventional methods in pattern classification due to extracting informative abstraction and featu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51334-2

    authors： Li G,Watanabe K,Anzai H,Song X,Qiao A,Ohta M

    更新日期：2019-10-17 00:00:00

  • Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM).

    abstract：:Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent activ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17475

    authors： Coghlan ML,Maker G,Crighton E,Haile J,Murray DC,White NE,Byard RW,Bellgard MI,Mullaney I,Trengove R,Allcock RJ,Nash C,Hoban C,Jarrett K,Edwards R,Musgrave IF,Bunce M

    更新日期：2015-12-10 00:00:00

  • Siliceous spicules in a vauxiid sponge (Demospongia) from the Kaili Biota(Cambrian Stage 5), Guizhou, South China.

    abstract：:Fossils of the sponge Angulosuspongia sinensis from calcareous mudstones of the middle and upper part of the Kaili Formation (Cambrian Stage 5) in the Jianhe area of Guizhou province, South China, exhibit an apparently reticulate pattern, characteristic of the Vauxiidae. Energy Dispersive X-Ray Spectrometry (EDS) and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42945

    authors： Yang XL,Zhao YL,Babcock LE,Peng J

    更新日期：2017-02-21 00:00:00

  • Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line.

    abstract：:Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes - two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) - with distinct protein and miRNA signatures. Here, we extend our omics approach to underst...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38397

    authors： Chen M,Xu R,Ji H,Greening DW,Rai A,Izumikawa K,Ishikawa H,Takahashi N,Simpson RJ

    更新日期：2016-12-05 00:00:00

  • Association between liver function and metabolic syndrome in Chinese men and women.

    abstract：:Metabolic syndrome (MS) could be associated with liver function. Our study aimed to investigate the association between liver function and MS in a large cohort of Chinese men and women. We enrolled 32,768 ostensibly healthy participants. The associations between liver function and MS of both genders were analyzed sepa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44844

    authors： Wang S,Zhang J,Zhu L,Song L,Meng Z,Jia Q,Li X,Liu N,Hu T,Zhou P,Zhang Q,Liu L,Song K,Jia Q

    更新日期：2017-03-20 00:00:00

  • Long-term survey of sea turtles (Caretta caretta) reveals correlations between parasite infection, feeding ecology, reproductive success and population dynamics.

    abstract：:Long-term monitoring of host-parasite interactions is important for understanding the consequences of infection on host fitness and population dynamics. In an eight-year survey of the loggerhead sea turtle (Caretta caretta) population nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus mar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75498-4

    authors： Lockley EC,Fouda L,Correia SM,Taxonera A,Nash LN,Fairweather K,Reischig T,Durão J,Dinis H,Roque SM,Lomba JP,Dos Passos L,Cameron SJK,Stiebens VA,Eizaguirre C

    更新日期：2020-10-29 00:00:00

  • We should be using nonlinear indices when relating heart-rate dynamics to cognition and mood.

    abstract：:Both heart rate (HR) and brain functioning involve the integrated output of a multitude of regulatory mechanisms, that are not quantified adequately by linear approximations such as means and standard deviations. It was therefore considered whether non-linear measures of HR complexity are more strongly associated with...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16619

    authors： Young H,Benton D

    更新日期：2015-11-13 00:00:00