Abstract:
:Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in Cannabis, which is studied extensively for its medicinal value. A central gap in the science is the underlying mechanisms surrounding THC's therapeutic effects and the role of gut metabolite profiles. Using a mass-spectrometry based metabolomics, we show here that intraperitoneal injection of THC in C57BL/6 mice modulates metabolic profiles that have previously been identified as integral to health. Specifically, we investigated the effects of acute (single THC injection denoted here as '1X') and short -term (five THC injections on alternate days denoted as '5X') THC administration on fecal and intestinal tissue metabolite profiles. Results are consistent with the hypothesis that THC administration alters host metabolism by targeting two prominent lipid metabolism pathways: glycerophospholipid metabolism and fatty acid biosynthesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Oza M,Becker W,Gummadidala PM,Dias T,Omebeyinje MH,Chen L,Mitra C,Jesmin R,Chakraborty P,Sajish M,Hofseth LJ,Banerjee K,Wang Q,Moeller PDR,Nagarkatti M,Nagarkatti P,Chanda Adoi
10.1038/s41598-019-46478-0subject
Has Abstractpub_date
2019-07-19 00:00:00pages
10520issue
1issn
2045-2322pii
10.1038/s41598-019-46478-0journal_volume
9pub_type
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