Comparison of Accuracy of Arrival-Time-Insensitive and Arrival-Time-Sensitive CTP Algorithms for Prediction of Infarct Tissue Volumes.

Abstract:

:The purpose of this study was to compare the performance of arrival-time-insensitive (ATI) and arrival-time-sensitive (ATS) computed tomography perfusion (CTP) algorithms in Philips IntelliSpace Portal (v9, ISP) and to investigate optimal thresholds for ATI regarding the prediction of final infarct volume (FIV). Retrospective, single-center study with 54 patients (mean 67.0 ± 13.1 years, 68.5% male) who received Stroke-CT/CTP-imaging between 2010 and 2018 with occlusion of the middle cerebral artery in the M1-/proximal M2-segment or terminal internal carotid artery. FIV was determined on short-term follow-up imaging in two patient groups: A) not attempted or failed mechanical thrombectomy (MT) and B) successful MT. ATS (default settings) and ATI (full-range of threshold settings regarding FIV prediction) maps were coregistered in 3D with FIV using voxel-wise overlap measurement. Based on an average imaging follow-up of 2.6 ± 2.1 days, the estimation regarding penumbra (group A, ATI: r = 0.63/0.69, ATS: r = 0.64) and infarct core (group B, ATI: r = 0.60/0.68, ATS: r = 0.63) was slightly higher in ATI but the effect was not significant (p > 0.05). Regarding ATI, Tmax (AUC 0.9) was the best estimator of the penumbra (group A), CBF relative to the contralateral hemisphere (AUC 0.80) showed the best estimation of the infarct core (group B). There was a broad range of thresholds of optimal ATI settings in both groups. Prediction of FIV with ATI was slightly better compared to ATS. However, this difference was not significant. Since ATI showed a broad range of optimal thresholds, exact thresholds regarding the ATI algorithm should be evaluated in further prospective, clinical studies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pennig L,Thiele F,Goertz L,Laukamp KR,Perkuhn M,Kabbasch C,Schlamann M,Fink GR,Borggrefe J

doi

10.1038/s41598-020-66041-6

subject

Has Abstract

pub_date

2020-06-09 00:00:00

pages

9252

issue

1

issn

2045-2322

pii

10.1038/s41598-020-66041-6

journal_volume

10

pub_type

杂志文章
  • Plasma Free Amino Acid Profiles Predict Four-Year Risk of Developing Diabetes, Metabolic Syndrome, Dyslipidemia, and Hypertension in Japanese Population.

    abstract::Plasma free amino acid (PFAA) profile is highlighted in its association with visceral obesity and hyperinsulinemia, and future diabetes. Indeed PFAA profiling potentially can evaluate individuals' future risks of developing lifestyle-related diseases, in addition to diabetes. However, few studies have been performed e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11918

    authors: Yamakado M,Nagao K,Imaizumi A,Tani M,Toda A,Tanaka T,Jinzu H,Miyano H,Yamamoto H,Daimon T,Horimoto K,Ishizaka Y

    更新日期:2015-07-09 00:00:00

  • Organized Disassembly of Photosynthesis During Programmed Cell Death Mediated By Long Chain Bases.

    abstract::In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65186-8

    authors: Zavafer A,González-Solís A,Palacios-Bahena S,Saucedo-García M,Tapia de Aquino C,Vázquez-Santana S,King-Díaz B,Gavilanes-Ruiz M

    更新日期:2020-06-25 00:00:00

  • Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo.

    abstract::Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37944

    authors: Ciarlo E,Heinonen T,Herderschee J,Fenwick C,Mombelli M,Le Roy D,Roger T

    更新日期:2016-11-29 00:00:00

  • Controlling soil disturbance of a lunar regolith simulant bed during depressurization in a vacuum chamber.

    abstract::A dusty thermal vacuum chamber (DTVC) containing a regolith simulant bed is essential for testing equipment and techniques related to lunar surface exploration. Space agencies have been reluctant to operate a DTVC because of the challenge of controlling soil disturbance of the lunar regolith simulant bed during pumpin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81317-1

    authors: Go GH,Lee J,Chung T,Ryu BH,Jin H,Zhuang L,Shin HS,Kim JH,Yun TS

    更新日期:2021-01-21 00:00:00

  • Plasmon excitations with a semi-integer angular momentum.

    abstract::We provide an explicit model for a spin-1/2 quasi-particle, based on the superposition of plasmon excitations in a quantum plasmas with intrinsic orbital angular momentum. Such quasi-particle solutions can show remarkable similarities with single electrons moving in vacuum: they have spin-1/2, a finite rest mass, and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26196-9

    authors: Mendonça JT,Serbeto A,Vieira J

    更新日期:2018-05-18 00:00:00

  • A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors.

    abstract::Success of immunotherapeutic approaches using genetically engineered antibodies and T cells modified with chimeric antigen receptors (CARs) depends, among other things, on the selection of antigen binding domains with desirable expression and binding characteristics. We developed a luciferase-based assay, termed Malib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59099-9

    authors: Natarajan V,Gopalakrishnan R,Matta H,Choi S,Gong S,Jeronimo A,Keerthipati PS,Morales A,Venkatesh H,Chaudhary PM

    更新日期:2020-02-11 00:00:00

  • Qualifying a eukaryotic cell-free system for fluorescence based GPCR analyses.

    abstract::Membrane proteins are key elements in cell-mediated processes. In particular, G protein-coupled receptors (GPCRs) have attracted increasing interest since they affect cellular signaling. Furthermore, mutations in GPCRs can cause acquired and inheritable diseases. Up to date, there still exist a number of GPCRs that ha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03955-8

    authors: Zemella A,Grossmann S,Sachse R,Sonnabend A,Schaefer M,Kubick S

    更新日期:2017-06-16 00:00:00

  • Haptoglobin polymorphism and prostate cancer mortality.

    abstract::Prostate cancer is a common malignancy in men worldwide and it is known that oxidative stress is a risk factor for cancer development. A common functional haptoglobin (Hp) polymorphism, originating from a duplication of a gene segment spanning over two exons, results in three distinct phenotypes with different anti-ox...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69333-z

    authors: Kaiser M,Thurner EM,Mangge H,Herrmann M,Semeraro MD,Renner W,Langsenlehner T

    更新日期:2020-08-04 00:00:00

  • The genetic and environmental aetiology of spatial, mathematics and general anxiety.

    abstract::Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42218

    authors: Malanchini M,Rimfeld K,Shakeshaft NG,Rodic M,Schofield K,Selzam S,Dale PS,Petrill SA,Kovas Y

    更新日期:2017-02-21 00:00:00

  • Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands.

    abstract::Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs (hASIC1V3, hASIC2a and hASIC3a) were heterologously expressed as hom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43097-7

    authors: Barth D,Fronius M

    更新日期:2019-05-01 00:00:00

  • Tobacco smoke and morphine alter peripheral and CNS inflammation following HIV infection in a humanized mouse model.

    abstract::Tobacco smoking is common in HIV-infected patients, and is prevalent among intravenous opiate abusers. Conversely, intravenous opiate abusers are more likely HIV-infected, and opiate abuse is associated with more severe neuroinflammation. Given the coincident use of tobacco smoking among HIV-infected intravenous drug ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70374-7

    authors: Cornwell WD,Sriram U,Seliga A,Zuluaga-Ramirez V,Gajghate S,Rom S,Winfield M,Heldt NA,Ambrose D,Rogers TJ,Persidsky Y

    更新日期:2020-08-19 00:00:00

  • Facile preparation of salivary extracellular vesicles for cancer proteomics.

    abstract::Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attract...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24669

    authors: Sun Y,Xia Z,Shang Z,Sun K,Niu X,Qian L,Fan LY,Cao CX,Xiao H

    更新日期:2016-04-19 00:00:00

  • Author Correction: Lithospheric mantle buoyancy: the role of tectonic convergence and mantle composition.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-57833-x

    authors: Boonma K,Kumar A,Garcia-Castellanos D,Jiménez-Munt I,Fernández M

    更新日期:2020-01-15 00:00:00

  • Direct observation of symmetrization of hydrogen bond in δ-AlOOH under mantle conditions using neutron diffraction.

    abstract::At ambient pressure, the hydrogen bond in materials such as ice, hydrates, and hydrous minerals that compose the Earth and icy planets generally takes an asymmetric O-H···O configuration. Pressure significantly affects this configuration, and it is predicted to become symmetric, such that the hydrogen is centered betw...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33598-2

    authors: Sano-Furukawa A,Hattori T,Komatsu K,Kagi H,Nagai T,Molaison JJ,Dos Santos AM,Tulk CA

    更新日期:2018-10-19 00:00:00

  • Effectiveness of Immersive Videos in Inducing Awe: An Experimental Study.

    abstract::Awe, a complex emotion composed by the appraisal components of vastness and need for accommodation, is a profound and often meaningful experience. Despite its importance, psychologists have only recently begun empirical study of awe. At the experimental level, a main issue concerns how to elicit high intensity awe exp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01242-0

    authors: Chirico A,Cipresso P,Yaden DB,Biassoni F,Riva G,Gaggioli A

    更新日期:2017-04-27 00:00:00

  • Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits.

    abstract::Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken anti-integrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that harboured all mapped epitopes recognized by mAbs...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13756

    authors: Nishimichi N,Kawashima N,Yokosaki Y

    更新日期:2015-09-09 00:00:00

  • Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.

    abstract::Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in JPH2 have been linked to hypertrophic cardiomyopathy; however, pathogenic "loss of function" (LOF) variants have not been described. Family-based genetic analysis ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44987-6

    authors: Jones EG,Mazaheri N,Maroofian R,Zamani M,Seifi T,Sedaghat A,Shariati G,Jamshidi Y,Allen HD,Wehrens XHT,Galehdari H,Landstrom AP

    更新日期:2019-06-21 00:00:00

  • Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study.

    abstract::We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteiniz...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37809

    authors: Chen C,Wang N,Zhai H,Nie X,Sun H,Han B,Li Q,Chen Y,Cheng J,Xia F,Zhao L,Zheng Y,Shen Z,Lu Y

    更新日期:2016-11-29 00:00:00

  • System wide channel network analysis reveals hotspots of morphological change in anthropogenically modified regions of the Ganges Delta.

    abstract::The Ganges Brahmaputra Meghna Delta (GBMD) is a large and complex coastal system whose channel network is vulnerable to morphological changes caused by sea level rise, subsidence, anthropogenic modifications, and changes to water and sediment loads. Locating and characterizing change is particularly challenging becaus...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69688-3

    authors: Jarriel T,Isikdogan LF,Bovik A,Passalacqua P

    更新日期:2020-07-30 00:00:00

  • Evaluation for pharmacokinetic exposure of cytotoxic anticancer drugs in elderly patients receiving (R-)CHOP therapy.

    abstract::(R-)miniCHOP therapy, which delivers approximately half-doses of the (R-)CHOP regimen, has shown efficacy and safety in patients who are more than 80 years old. This study aimed to compare the area under the plasma concentration-time curves (AUCs) of vincristine (VCR), doxorubicin (DXR), and cyclophosphamide (CPA) bet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80706-2

    authors: Nakagawa J,Takahata T,Hyodo R,Chen Y,Hasui K,Sasaki K,Saito K,Ueno K,Hosoi K,Terui K,Sato A,Niioka T

    更新日期:2021-01-12 00:00:00

  • Author Correction: A transgenic embryonic sexing system for the Australian sheep blow fly Lucilia cuprina.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-63126-0

    authors: Yan Y,Scott MJ

    更新日期:2020-04-20 00:00:00

  • Shoulder tenderness was associated with the inflammatory changes on magnetic resonance imaging in patients with rheumatoid arthritis.

    abstract::The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55938-6

    authors: Shinagawa S,Okamura K,Yonemoto Y,Shitara H,Suto T,Sakane H,Dam TT,Tajika T,Tsushima Y,Takagishi K,Chikuda H

    更新日期:2019-12-20 00:00:00

  • Contact effects in thin 3D-topological insulators: how does the current flow?

    abstract::The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent cu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09479

    authors: Gupta G,Jalil MB,Liang G

    更新日期:2015-03-30 00:00:00

  • SERS activity of hybrid nano/microstructures Ag-Fe3O4 based on Dimorphotheca ecklonis pollen grains as bio-template.

    abstract::Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73615-x

    authors: Ávila-Avilés RD,Torres-Gómez N,Camacho-López MA,Vilchis-Nestor AR

    更新日期:2020-10-06 00:00:00

  • Usefulness and limitations of sample pooling for environmental DNA metabarcoding of freshwater fish communities.

    abstract::Environmental DNA (eDNA) metabarcoding has been used increasingly to assess biodiversity of aquatic vertebrates. However, there still remains to be developed a sampling design of eDNA metabarcoding that can ensure high detection rates of species with minimum total survey effort, especially for large-scale surveys of a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14978-6

    authors: Sato H,Sogo Y,Doi H,Yamanaka H

    更新日期:2017-11-01 00:00:00

  • Water and Ethanol Droplet Wetting Transition during Evaporation on Omniphobic Surfaces.

    abstract::Omniphobic surfaces with reentrant microstructures have been investigated for a range of applications, but the evaporation of high- and low-surface-tension liquid droplets placed on such surfaces has not been rigorously studied. In this work, we develop a technique to fabricate omniphobic surfaces on copper substrates...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17110

    authors: Chen X,Weibel JA,Garimella SV

    更新日期:2015-11-25 00:00:00

  • Individual differences predict endorsement of water resilience.

    abstract::In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62896-x

    authors: Baird J,Dale G,Farhad S

    更新日期:2020-04-06 00:00:00

  • Switchable plasmonic routers controlled by external magnetic fields by using magneto-plasmonic waveguides.

    abstract::We analytically and numerically investigate magneto-plasmons in metal films surrounded by a ferromagnetic dielectric. In such waveguide using a metal film with a thickness exceeding the Skin depth, an external magnetic field in the transverse direction can induce a significant spatial asymmetry of mode distribution. S...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28567-8

    authors: Ho KS,Im SJ,Pae JS,Ri CS,Han YH,Herrmann J

    更新日期:2018-07-12 00:00:00

  • Postmenopausal Osteoporosis reference genes for qPCR expression assays.

    abstract::Osteoporosis (OP) is a multifactorial disease influenced by genetic factors in more than half of the cases. In spite of the efforts to clarify the relationship among genetic factors and susceptibility to develop OP, many genetic associations need to be further functionally validated. Besides, some limitations as the c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52612-9

    authors: de Lima CAD,de Lima SC,Barbosa AD,Sandrin-Garcia P,de Barros Pita W,de Azevêdo Silva J,Crovella S

    更新日期:2019-11-11 00:00:00

  • Association between newborn screening analytes and hypoxic ischemic encephalopathy.

    abstract::Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. Our study sought to examine whether patterns of newborn screening analytes differed between infants with and without neonatal HIE in order to identify opportunities for potential use of these analytes for diagnosis in routine c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51919-x

    authors: Wilson LA,Fell DB,Hawken S,Wong CA,Murphy MSQ,Little J,Potter BK,Walker M,Lacaze-Masmonteil T,Juul S,Chakraborty P,Wilson K

    更新日期:2019-10-31 00:00:00