Abstract:
:Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-specific assembly of proteins, such as albumin, immunoglobulin and protamine, on {100} facets of SrTiO3 polyhedral nanocrystals, while none on {110} facets. Molecular dynamics simulations indicate the immobile surface hydration layer might play a barrier role to effectively prevent proteins adsorption on specific {110} facets. This work thus provides new insights into the fundamentally understanding of protein-nanomaterial interactions, and open a novel, general and facile route to control the selective adsorption of various proteins on various nanocrystals.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dong L,Luo Q,Cheng K,Shi H,Wang Q,Weng W,Han WQdoi
10.1038/srep05084subject
Has Abstractpub_date
2014-05-28 00:00:00pages
5084issn
2045-2322pii
srep05084journal_volume
4pub_type
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