Ultrahigh brilliance quasi-monochromatic MeV γ-rays based on self-synchronized all-optical Compton scattering.

abstract：:Olfactory dysfunction is a robust and early sign for Parkinson's disease (PD). Previous studies have revealed its association with dementia and related neural changes in PD. Yet, how olfactory dysfunction affects white matter (WM) microstructure in newly diagnosed and untreated PD remains unclear. Here we comprehensiv...

journal_title：Scientific reports

authors： Wen MC,Xu Z,Lu Z,Chan LL,Tan EK,Tan LCS

更新日期：2017-10-02 00:00:00

abstract：:Geographically diverse samples from strawberry exhibiting symptoms of Strawberry Green Petal (SbGP), periwinkle plants with virescence, and blackberry, blueberry, and raspberry plants displaying yellowing and inedible fruits, were assayed for the presence of phytoplasma DNA. PCR targeting the 16S rRNA-encoding gene an...

journal_title：Scientific reports

authors： Pérez-López E,Rodríguez-Martínez D,Olivier CY,Luna-Rodríguez M,Dumonceaux TJ

更新日期：2017-04-19 00:00:00

abstract：:The familial forms of early onset pre-eclampsia and related syndromes (HELLP) present with hypertension and proteinuria in the mother and growth restriction of the fetus. Genetically, these clinically similar entities are caused by different founder-dependent, placentally-expressed paralogous genes. All susceptibility...

journal_title：Scientific reports

authors： Oudejans CB,Poutsma A,Michel OJ,Thulluru HK,Mulders J,van de Vrugt HJ,Sistermans EA,van Dijk M

更新日期：2016-08-24 00:00:00

abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...

journal_title：Scientific reports

authors： Ma T,Peng Y,Huang W,Ding J

更新日期：2017-01-18 00:00:00

abstract：:Single-photon emitters with stable and uniform photoluminescence properties are important for quantum technology. However, in many cases, colour centres in diamond exhibit spectral diffusion and photoluminescence intensity fluctuation. It is therefore essential to investigate the dynamics of colour centres at the sing...

journal_title：Scientific reports

authors： Liu Y,Chen G,Rong Y,McGuinness LP,Jelezko F,Tamura S,Tanii T,Teraji T,Onoda S,Ohshima T,Isoya J,Shinada T,Wu E,Zeng H

更新日期：2015-07-23 00:00:00

abstract：:The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3'- and 5'-ends of the vRNA segment. The IAV RdRp is an imp...

journal_title：Scientific reports

authors： Swale C,Monod A,Tengo L,Labaronne A,Garzoni F,Bourhis JM,Cusack S,Schoehn G,Berger I,Ruigrok RW,Crépin T

更新日期：2016-04-20 00:00:00

abstract：:Advanced glycation end-products (AGEs)-induced mesangial cell death is one of major causes of glomerulus dysfunction in diabetic nephropathy. Both endoplasmic reticulum (ER) stress and autophagy are adaptive responses in cells under environmental stress and participate in the renal diseases. The role of ER stress and ...

journal_title：Scientific reports

authors： Chiang CK,Wang CC,Lu TF,Huang KH,Sheu ML,Liu SH,Hung KY

更新日期：2016-09-26 00:00:00

abstract：:Shoulder problems are common in patients with a cervical herniated intervertebral disc (HIVD). This study aimed to explore the incidence and risk of shoulder capsulitis/tendonitis following cervical HIVD surgery. We used data from the Taiwan "Longitudinal Health Insurance Database". We identified all patients who were...

journal_title：Scientific reports

authors： Kang JH,Lin HC,Tsai MC,Chung SD

更新日期：2016-05-27 00:00:00

abstract：:The ability of marine invertebrate larvae to control their vertical position shapes their dispersal pattern. In species characterized by large variations in population density, like many echinoderm species, larval dispersal may contribute to outbreak and die-off phenomena. A proliferation of the ophiuroid Ophiocomina ...

journal_title：Scientific reports

authors： Guillam M,Bessin C,Blanchet-Aurigny A,Cugier P,Nicolle A,Thiébaut É,Comtet T

更新日期：2020-07-21 00:00:00

abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

journal_title：Scientific reports

authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

更新日期：2017-07-26 00:00:00

abstract：:The propagation of Toxoplasma gondii is accomplished by repeated lytic cycles of parasite attachment to a host cell, invasion, replication within a parasitophorous vacuole, and egress from the cell. This lytic cycle is delicately regulated by calcium-dependent reversible phosphorylation of the molecular machinery that...

journal_title：Scientific reports

authors： Yang C,Broncel M,Dominicus C,Sampson E,Blakely WJ,Treeck M,Arrizabalaga G

更新日期：2019-04-11 00:00:00

abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...

journal_title：Scientific reports

authors： Jia Z,Huang X,Wu H,Zhang T,Li N,Ding P,Sun Y,Liu Z,Wei F,Zhang H,Jiao Y,Ji Y,Zhang Y,Guo C,Li W,Mou D,Xia W,Li Z,Chen D,Yan H,Chen X,Zhao J,Meyers K,Cohen T,Mayer K,Salomon JA,Lu Z,Dye C

更新日期：2015-07-02 00:00:00

abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...

journal_title：Scientific reports

authors： Bajgain P,Russell B,Mohammadi M

更新日期：2018-05-04 00:00:00

abstract：:Membrane proteins are distinguished from soluble proteins by their insertion into biological membranes. This insertion is achieved via a noticeable arrangement of hydrophobic amino acids that are exposed at the surface of the protein, and renders the interaction with the aliphatic tails of lipids more energetically fa...

journal_title：Scientific reports

authors： Robert X,Kassis-Sahyoun J,Ceres N,Martin J,Sawaya MR,Read RJ,Gouet P,Falson P,Chaptal V

更新日期：2017-12-05 00:00:00

abstract：:K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...

journal_title：Scientific reports

authors： Vatansever S,Erman B,Gümüş ZH

更新日期：2019-08-13 00:00:00

abstract：:Centrosomal protein 55 (CEP55) is a microtubule-bundling protein that participants in cell mitosis. It is overexpressed in several solid tumours and promotes the growth and invasion of cancer cells. However, the role of CEP55 in pancreatic cancer (PANC) remains unclear. Herein, upregulated expression of CEP55 (associa...

journal_title：Scientific reports

authors： Peng T,Zhou W,Guo F,Wu HS,Wang CY,Wang L,Yang ZY

更新日期：2017-07-19 00:00:00

abstract：:The endoplasmic reticulum (ER) is a multi functional organelle and plays a crucial role in protein folding and lipid biosynthesis. The SEC59 gene encodes dolichol kinase, required for protein glycosylation in the ER. The mutation of sec59-1 caused a protein N-glycosylation defect mediated ER stress resulting in increa...

journal_title：Scientific reports

authors： William James A,Ravi C,Srinivasan M,Nachiappan V

更新日期：2019-10-09 00:00:00

abstract：:Denitrification in coastal sediments can provide resilience to eutrophication in estuarine ecosystems, but this key ecosystem function is impacted directly and indirectly by increasing stressors. The erosion and loading of fine sediments from land, resulting in sedimentation and elevated sediment muddiness, presents a...

journal_title：Scientific reports

authors： Douglas EJ,Lohrer AM,Pilditch CA

更新日期：2019-11-26 00:00:00

abstract：:Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with ant...

journal_title：Scientific reports

authors： Zhu XY,Guo DW,Lao QC,Xu YQ,Meng ZK,Xia B,Yang H,Li CQ,Li P

更新日期：2019-03-14 00:00:00

abstract：:Natural hazards including floods can trigger catastrophic failures in interdependent urban transport network-of-networks (NoNs). Population growth has enhanced transportation demand while urbanization and climate change have intensified urban floods. However, despite the clear need to develop actionable insights for i...

journal_title：Scientific reports

authors： Yadav N,Chatterjee S,Ganguly AR

更新日期：2020-06-25 00:00:00

abstract：:Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used in the treatment of various gastrointestinal (GI) disorders. The...

journal_title：Scientific reports

authors： Yu M,Jia HM,Zhou C,Yang Y,Sun LL,Zou ZM

更新日期：2017-04-20 00:00:00

abstract：:Three dimensional (3D) co-cultures to mimic cellular dynamics have brought significant impacts in tissue engineering approaches for biomedical research. Herein, we present a novel sample holder combined with time-lapse fluorescence imaging technique, referred as 4D live cell imaging, allowing direct visualization of v...

journal_title：Scientific reports

authors： Septiadi D,Bourquin J,Durantie E,Petri-Fink A,Rothen-Rutishauser B

更新日期：2018-06-29 00:00:00

abstract：:Induction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the treatment outcomes and toxicities between two induction chemotherapy regimens, with both followed by concurrent chemoradiotherapy. The first strategy used docetaxel, cisplatin and fluorouraci...

journal_title：Scientific reports

authors： Zeng Z,Yan RN,Tu L,Wang YY,Chen PR,Luo F,Liu L

更新日期：2018-10-22 00:00:00

abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...

journal_title：Scientific reports

authors： Hu S,Gu F,Chen M,Wang C,Li J,Yang J,Wang G,Zhou Z,Yang Y

更新日期：2020-07-27 00:00:00

abstract：:Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used con...

journal_title：Scientific reports

authors： Agnoli C,Grioni S,Pala V,Allione A,Matullo G,Gaetano CD,Tagliabue G,Sieri S,Krogh V

更新日期：2017-10-05 00:00:00

abstract：:Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in ombrotrophic peatlands of Patagonia. BNF of ...

journal_title：Scientific reports

authors： Borken W,Horn MA,Geimer S,Aguilar NA,Knorr KH

更新日期：2016-12-15 00:00:00

abstract：:Cysteine based silver-gold nanocomposite (Cys/Ag-Au NCz) was synthesized, this was followed by its characterization using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Ultraviolet-visible spectroscopy (UV-Vis), Scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDAX), ...

journal_title：Scientific reports

authors： Basik M,Mobin M,Shoeb M

更新日期：2020-01-14 00:00:00

abstract：:Control of parasite transmission is critical for the eradication of malaria. However, most antimalarial drugs are not active against P. falciparum gametocytes, responsible for the spread of malaria. Consequently, patients can remain infectious for weeks after the clearance of asexual parasites and clinical symptoms. H...

journal_title：Scientific reports

authors： Sun W,Tanaka TQ,Magle CT,Huang W,Southall N,Huang R,Dehdashti SJ,McKew JC,Williamson KC,Zheng W

更新日期：2014-01-17 00:00:00

abstract：:Long non-coding RNAs (LNC) regulate numerous biological processes. In contrast to human, the identification of LNC in farm species, like chicken, is still lacunar. We propose a catalogue of 52,075 chicken genes enriched in LNC ( http://www.fragencode.org/ ), built from the Ensembl reference extended using novel LNC mo...

journal_title：Scientific reports

authors： Jehl F,Muret K,Bernard M,Boutin M,Lagoutte L,Désert C,Dehais P,Esquerré D,Acloque H,Giuffra E,Djebali S,Foissac S,Derrien T,Pitel F,Zerjal T,Klopp C,Lagarrigue S

更新日期：2020-11-24 00:00:00

abstract：:Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...

journal_title：Scientific reports

authors： Guevara T,Körschgen H,Cuppari A,Schmitz C,Kuske M,Yiallouros I,Floehr J,Jahnen-Dechent W,Stöcker W,Gomis-Rüth FX

更新日期：2019-10-11 00:00:00