Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis.

abstract：:Most glioblastoma patients have a dismal prognosis, although some survive several years. However, only few biomarkers are available to predict the disease course. EGR1 and EGR3 have been linked to glioblastoma stemness and tumour progression, and this study aimed to investigate their spatial expression and prognostic ...

journal_title：Scientific reports

authors： Knudsen AM,Eilertsen I,Kielland S,Pedersen MW,Sørensen MD,Dahlrot RH,Boldt HB,Munthe S,Poulsen FR,Kristensen BW

更新日期：2020-06-09 00:00:00

abstract：:RNaseIII proteins are dsRNA-specific endonucleases involved in many important biological processes, such as small RNA processing and maturation in eukaryotes. Various small RNAs have been identified in a protozoan parasite Entamoeba histolytica. EhRNaseIII is the only RNaseIII endonuclease domain (RIIID)-containing pr...

journal_title：Scientific reports

authors： Yu X,Li X,Zheng L,Ma J,Gan J

更新日期：2017-03-20 00:00:00

abstract：:Arsenic contamination of groundwater is a serious concern worldwide. The research gaps in removing arsenic are selectivity, regeneration and effective removal rate at neutral pH levels. In this study, we discussed the reasons of the high arsenic adsorption from groundwater of our previously developed adsorbent, a cati...

journal_title：Scientific reports

authors： Safi SR,Senmoto K,Gotoh T,Iizawa T,Nakai S

更新日期：2019-08-15 00:00:00

abstract：:Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...

journal_title：Scientific reports

authors： Chen X,Chen X,Pedone A,Apperley D,Hill RG,Karpukhina N

更新日期：2018-01-22 00:00:00

abstract：:Brain-computer interfaces enable active communication and execution of a pre-defined set of commands, such as typing a letter or moving a cursor. However, they have thus far not been able to infer more complex intentions or adapt more complex output based on brain signals. Here, we present neuroadaptive generative mod...

journal_title：Scientific reports

authors： Kangassalo L,Spapé M,Ruotsalo T

更新日期：2020-09-07 00:00:00

abstract：:The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to e...

journal_title：Scientific reports

authors： Bernegger A,Kienesberger K,Carlberg L,Swoboda P,Ludwig B,Koller R,Inaner M,Zotter M,Kapusta N,Aigner M,Haslacher H,Kasper S,Schosser A

更新日期：2018-01-12 00:00:00

abstract：:Geophysical data from the South Kara Sea reveal U-shaped erosional structures buried beneath the 50-250 m deep seafloor of the continental shelf across an area of ~32 000 km2. These structures are interpreted as thermokarst, formed in ancient yedoma terrains during Quaternary interglacial periods. Based on comparison ...

journal_title：Scientific reports

authors： Portnov A,Mienert J,Winsborrow M,Andreassen K,Vadakkepuliyambatta S,Semenov P,Gataullin V

更新日期：2018-09-25 00:00:00

abstract：:This study was designed to evaluate the prognostic value of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC). A comprehensive literature search for relevant studies was performed in Web of science, Embase and Pubmed. A total of nine studies with 2017 patients were included in this meta-analysis, an...

journal_title：Scientific reports

authors： Ma W,Zhang P,Qi J,Gu L,Zang M,Yao H,Shi X,Wang C,Jiang Y

更新日期：2016-10-14 00:00:00

abstract：:Sexual segregation in foraging occurs in many animal species, resulting in the partitioning of resources and reduction of competition between males and females, yet the patterns and drivers of such segregation are still poorly understood. We studied the foraging movements (GPS-tracking), habitat use (habitat modelling...

journal_title：Scientific reports

authors： Paiva VH,Pereira J,Ceia FR,Ramos JA

更新日期：2017-06-01 00:00:00

abstract：:In this population-based retrospective study, we aimed to investigate the association between age at diagnosis and prognosis of pancreatic cancer (PC) patients using data from the National Cancer Institute's Surveillance, Epidemiology, and the End Results database. Different factors for stratification, like race, sex,...

journal_title：Scientific reports

authors： Wang H,Liu J,Xia G,Lei S,Huang X,Huang X

更新日期：2020-04-27 00:00:00

abstract：:Biomaterial development for tissue engineering applications is rapidly increasing but necessitates efficacy and safety testing prior to clinical application. Current in vitro and in vivo models hold a number of limitations, including expense, lack of correlation between animal models and human outcomes and the need to...

journal_title：Scientific reports

authors： Moreno-Jiménez I,Hulsart-Billstrom G,Lanham SA,Janeczek AA,Kontouli N,Kanczler JM,Evans ND,Oreffo RO

更新日期：2016-08-31 00:00:00

abstract：:The strange three-dimensional flight behaviour of slowly spinning soccer balls is one of the most interesting and unknown phenomenon associated with the trajectories of sports balls. Many spectators have experienced numerous exciting and emotional instances while observing the curious flight behaviour of these balls. ...

journal_title：Scientific reports

authors： Mizota T,Kurogi K,Ohya Y,Okajima A,Naruo T,Kawamura Y

更新日期：2013-01-01 00:00:00

abstract：:Ataxia-telangiectasia (AT) and related disorders feature cancer predisposition, neurodegeneration, and immunodeficiency resulting from failure to respond to DNA damage. Hypomorphic mutations in MRE11 cause an AT-like disorder (ATLD) with variable clinical presentation. We have sought to understand how diverse MRE11 mu...

journal_title：Scientific reports

authors： Hartlerode AJ,Regal JA,Ferguson DO

更新日期：2018-07-04 00:00:00

abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...

journal_title：Scientific reports

authors： Guerra S,Peressotti A,Peressotti F,Bulgheroni M,Baccinelli W,D'Amico E,Gómez A,Massaccesi S,Ceccarini F,Castiello U

更新日期：2019-11-12 00:00:00

abstract：:The objective of this study was to assess the diagnosis value of urinary inflammatory index (UII) and systemic immune-inflammation index (SII) for UTI. Nine inflammatory indexes including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, SII and six UIIs were calculated for Receiver operating characteristi...

journal_title：Scientific reports

authors： Gu W,Huang W,Zhang J,Qian S,Cao H,Ge L

更新日期：2020-11-09 00:00:00

abstract：:Non-availability of an ideal alternative for autografts in treating critical-size bone defects is a major challenge in orthopedics. Phytocompounds have been proven to enhance osteogenesis via various osteogenic signaling pathways, but its decreased bioavailability and increased renal clearance limit its application. I...

journal_title：Scientific reports

authors： Chandran SV,Vairamani M,Selvamurugan N

更新日期：2019-08-15 00:00:00

abstract：:Soil pH is commonly considered a dominant factor affecting the function of microbiota. Few studies, however, have focused on communities of bacteria able to solubilize inorganic phosphate (iPSB), which are important for the mobilization of soil phosphorus (P), because finding an effective method to assess the abundanc...

journal_title：Scientific reports

authors： Zheng BX,Zhang DP,Wang Y,Hao XL,Wadaan MAM,Hozzein WN,Peñuelas J,Zhu YG,Yang XR

更新日期：2019-01-10 00:00:00

abstract：:Biomass waste products from green algae have recently been given new life, as these polysaccharides have potential applications in industry, agriculture, and medicine. One such polysaccharide group called ulvans displays many different, potentially useful properties that arise from their structural versatility. Hence,...

journal_title：Scientific reports

authors： Melcher RL,Neumann M,Fuenzalida Werner JP,Gröhn F,Moerschbacher BM

更新日期：2017-03-22 00:00:00

abstract：:Outer membrane vesicles (OMVs) have proven to be highly immunogenic and induced an immune response against bacterial infection in human clinics and animal models. We sought to investigate whether engineered OMVs can be a feasible antigen-delivery platform for efficiently inducing specific antibody responses. In this s...

journal_title：Scientific reports

authors： Huang W,Wang S,Yao Y,Xia Y,Yang X,Li K,Sun P,Liu C,Sun W,Bai H,Chu X,Li Y,Ma Y

更新日期：2016-11-16 00:00:00

abstract：:Here we present an experimental as well as theoretical study of third-harmonic generation in tightly focused femtosecond filaments in air at the wavelength of [Formula: see text]. At low intensities, longitudinal phase matching is dominating in the formation of 3rd harmonics, whereas at higher intensities locked X-wav...

journal_title：Scientific reports

authors： Tamulienė V,Juškevičiūtė G,Buožius D,Vaičaitis V,Babushkin I,Morgner U

更新日期：2020-10-15 00:00:00

abstract：:Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...

journal_title：Scientific reports

authors： Mölzer C,Wallner M,Kern C,Tosevska A,Zadnikar R,Doberer D,Marculescu R,Wagner KH

更新日期：2017-04-07 00:00:00

abstract：:Endosymbioses are driving forces underlying cell evolution. The endosymbiosis exhibited by Paramecium bursaria is an excellent model with which to study symbiosis. A single-cell microscopic analysis of P. bursaria reveals that endosymbiont numbers double when the host is in the division phase. Consequently, endosymbio...

journal_title：Scientific reports

authors： Takahashi T

更新日期：2016-08-17 00:00:00

abstract：:Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...

journal_title：Scientific reports

authors： Salihovic S,Broeckling CD,Ganna A,Prenni JE,Sundström J,Berne C,Lind L,Ingelsson E,Fall T,Ärnlöv J,Nowak C

更新日期：2020-10-05 00:00:00

abstract：:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...

journal_title：Scientific reports

authors： Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MW

更新日期：2019-01-29 00:00:00

abstract：:Copper zinc tin sulfide (CZTS) is a promising material for harvesting solar energy due to its abundance and non-toxicity. However, its poor performance hinders their wide application. In this paper gold (Au) nanoparticles are successfully incorporated into CZTS to form Au@CZTS core-shell nanostructures. The photocatho...

journal_title：Scientific reports

authors： Zhang X,Wu X,Centeno A,Ryan MP,Alford NM,Riley DJ,Xie F

更新日期：2016-03-21 00:00:00

abstract：:At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...

journal_title：Scientific reports

authors： Lisowska KA,Pindel M,Pietruczuk K,Kuźmiuk-Glembin I,Storoniak H,Dębska-Ślizień A,Witkowski JM

更新日期：2019-03-25 00:00:00

abstract：:Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances. To investigate genomic alterations associated with relapse and therapy resistance, whole-genome sequencing was performed on diagnostic and relapsed lesions toge...

journal_title：Scientific reports

authors： Fransson S,Martinez-Monleon A,Johansson M,Sjöberg RM,Björklund C,Ljungman G,Ek T,Kogner P,Martinsson T

更新日期：2020-12-31 00:00:00

abstract：:Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanical loading. We know from clinical experience that malrotation of surgical nasoseptal cartilage grafts can lead to increased graft absorption. Other studies have al...

journal_title：Scientific reports

authors： Jessop ZM,Zhang Y,Simoes IN,Al-Sabah A,Badiei N,Gazze SA,Francis L,Whitaker IS

更新日期：2019-08-28 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascades, which play crucial roles in plant development processes, are universal modules of signal transduction in eukaryotes and consist of a core module of three sequentially phosphorylated kinases: MAPK, MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK). This is the first re...

journal_title：Scientific reports

authors： Jing T,Wang L,Liu H,Wuyun TN,Du H

更新日期：2017-12-18 00:00:00

abstract：:A possible association between depression and either the severity of constipation or dysosmia in Parkinson's disease (PD) patients was investigated in this cross-sectional study. One-hundred six patients who had the history of PD for less than 5 years were recruited. Depression was measured using the Beck Depression I...

journal_title：Scientific reports

authors： Chang TY,Chen YH,Chang MH,Lin CH

更新日期：2020-09-23 00:00:00