Prognostic value of platelet to lymphocyte ratio in hepatocellular carcinoma: a meta-analysis.

abstract：:CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulation (NF), composed of...

journal_title：Scientific reports

authors： Kaushik A,Yndart A,Atluri V,Tiwari S,Tomitaka A,Gupta P,Jayant RD,Alvarez-Carbonell D,Khalili K,Nair M

更新日期：2019-03-08 00:00:00

abstract：:The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...

journal_title：Scientific reports

authors： Darthy RR,Venkateswaran C,Subramanian V,Ouyang Z,Yogesh N

更新日期：2020-07-06 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00

abstract：:Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...

journal_title：Scientific reports

authors： Tsuruya A,Kuwahara A,Saito Y,Yamaguchi H,Tsubo T,Suga S,Inai M,Aoki Y,Takahashi S,Tsutsumi E,Suwa Y,Morita H,Kinoshita K,Totsuka Y,Suda W,Oshima K,Hattori M,Mizukami T,Yokoyama A,Shimoyama T,Nakayama T

更新日期：2016-06-13 00:00:00

abstract：:Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing...

journal_title：Scientific reports

authors： Wang J,Qi J,Zhao H,He S,Zhang Y,Wei S,Zhao F

更新日期：2013-01-01 00:00:00

abstract：:Although microbes influence plant growth, little is known about the impact of microbial diversity on plant fitness trade-offs, intraspecific-interactions, and soil nutrient dynamics in the context of biodiversity-ecosystem functioning (BEF) research. The BEF theory states that higher species richness can enhance ecosy...

journal_title：Scientific reports

authors： Sahib MR,Pervaiz ZH,Williams MA,Saleem M,DeBolt S

更新日期：2020-09-22 00:00:00

abstract：:Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here present the identificatio...

journal_title：Scientific reports

authors： Arya T,Oudouhou F,Casu B,Bessette B,Sygusch J,Baron C

更新日期：2019-04-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Santra M,Sharma M,Katoch D,Jain S,Saikia UN,Dogra MR,Luthra-Guptasarma M

更新日期：2020-07-16 00:00:00

abstract：:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

journal_title：Scientific reports

authors： Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

更新日期：2020-01-28 00:00:00

abstract：:Hematopoietic stem/progenitor cells (HSPC) in zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopoietic tissue (CHT), where they expand and differentiate during definitive hematopoiesis. Phospholipase C gamma 1 (Plcγ1) has been implicated for hematopoiesis in vivo and in ...

journal_title：Scientific reports

authors： Ferri-Lagneau KF,Haider J,Sang S,Leung T

更新日期：2019-01-21 00:00:00

abstract：:Curvature components derived from satellite gravity gradients provide new global views of Earth's structure. The satellite gravity gradients are based on the GOCE satellite mission and we illustrate by curvature images how the Earth is seen differently compared to seismic imaging. Tectonic domains with similar seismic...

journal_title：Scientific reports

authors： Ebbing J,Haas P,Ferraccioli F,Pappa F,Szwillus W,Bouman J

更新日期：2018-11-05 00:00:00

abstract：:In mature erythrocytes, glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) yield NADPH, a crucial cofactor of the enzyme glutathione reductase (GR) converting glutathione disulfide (GSSG) into its reduced state (GSH). GSH is essential for detoxification processes in and survival of ...

journal_title：Scientific reports

authors： Ghashghaeinia M,Giustarini D,Koralkova P,Köberle M,Alzoubi K,Bissinger R,Hosseinzadeh Z,Dreischer P,Bernhardt I,Lang F,Toulany M,Wieder T,Mojzikova R,Rossi R,Mrowietz U

更新日期：2016-06-29 00:00:00

abstract：:During folliculogenesis, primary oocytes of teleosts grow by several orders of magnitude by-self synthesizing proteins and mRNA, or sequestering from blood specific macromolecular components, such as fatty acids and vitellogenin. All these materials are stored into cortical alveoli, yolk globules or oil droplets durin...

journal_title：Scientific reports

authors： Carnevali O,Candelma M,Sagrati A,Pignalosa P,Giorgini E,Gioacchini G

更新日期：2019-06-20 00:00:00

abstract：:Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here,...

journal_title：Scientific reports

authors： Salomão NG,Rabelo K,Póvoa TF,Alves AMB,da Costa SM,Gonçalves AJS,Amorim JF,Azevedo AS,Nunes PCG,Basílio-de-Oliveira CA,Basílio-de-Oliveira RP,Geraldo LHM,Fonseca CG,Lima FRS,Mohana-Borges R,Silva EM,Dos Santos FB,Olivei

更新日期：2018-06-27 00:00:00

abstract：:The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial dysfunction. Furthermore, it can be activated in the cytosol by mitochondrial oxidative str...

journal_title：Scientific reports

authors： Blignaut M,Loos B,Botchway SW,Parker AW,Huisamen B

更新日期：2019-03-18 00:00:00

abstract：:The Martian outflow channels comprise some of the largest known channels in the Solar System. Remote-sensing investigations indicate that cataclysmic floods likely excavated the channels ~3.4 Ga. Previous studies show that, in the southern circum-Chryse region, their flooding pathways include hundreds of kilometers of...

journal_title：Scientific reports

authors： Rodriguez JAP,Baker VR,Liu T,Zarroca M,Travis B,Hui T,Komatsu G,Berman DC,Linares R,Sykes MV,Banks ME,Kargel JS

更新日期：2019-02-25 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Dahan A,Reiner M

更新日期：2018-04-24 00:00:00

abstract：:Coexistence of physical phenomena can occur in quite unexpected ways. Here we demonstrate the first evidence in any physical system of the coexistence in the same set of measurements of two of the most challenging phenomena in complex systems: turbulence and spin glasses. We employ a quasi-one-dimensional random fibre...

journal_title：Scientific reports

authors： González IRR,Raposo EP,Macêdo AMS,de S Menezes L,Gomes ASL

更新日期：2018-11-19 00:00:00

abstract：:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and...

journal_title：Scientific reports

authors： Varley TF,Luppi AI,Pappas I,Naci L,Adapa R,Owen AM,Menon DK,Stamatakis EA

更新日期：2020-01-23 00:00:00

abstract：:Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...

journal_title：Scientific reports

authors： Kobayashi E,Nakano M,Kubota K,Himuro N,Mizoguchi S,Chikenji T,Otani M,Mizue Y,Nagaishi K,Fujimiya M

更新日期：2018-01-26 00:00:00

abstract：:We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and...

journal_title：Scientific reports

authors： Yoon J,Lee M,Lee K,Kim N,Kim JM,Park J,Yu H,Choi C,Heo WD,Park Y

更新日期：2015-08-21 00:00:00

abstract：:Identification of mutants with impairments in auxin biosynthesis and dynamics by forward genetic screening is hindered by the complexity, redundancy and necessity of the pathways involved. Furthermore, although a few auxin-deficient mutants have been recently identified by screening for altered responses to shade, eth...

journal_title：Scientific reports

authors： Wu L,Luo P,Di DW,Wang L,Wang M,Lu CK,Wei SD,Zhang L,Zhang TZ,Amakorová P,Strnad M,Novák O,Guo GQ

更新日期：2015-07-06 00:00:00

abstract：:Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating a...

journal_title：Scientific reports

authors： Kasera S,Herrmann LO,del Barrio J,Baumberg JJ,Scherman OA

更新日期：2014-10-30 00:00:00

abstract：:Rolling circle amplification (RCA) for generation of distinct fluorescent signals in situ relies upon the self-collapsing properties of single-stranded DNA in commonly used RCA-based methods. By introducing a cross-hybridizing DNA oligonucleotide during rolling circle amplification, we demonstrate that the fluorophore...

journal_title：Scientific reports

authors： Clausson CM,Arngården L,Ishaq O,Klaesson A,Kühnemund M,Grannas K,Koos B,Qian X,Ranefall P,Krzywkowski T,Brismar H,Nilsson M,Wählby C,Söderberg O

更新日期：2015-07-23 00:00:00

abstract：:The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a mechanism of insulin resistance. We examined skeletal muscle of T1D rats to determine if alterations in lipid metabolism were evident an...

journal_title：Scientific reports

authors： Dotzert MS,Murray MR,McDonald MW,Olver TD,Velenosi TJ,Hennop A,Noble EG,Urquhart BL,Melling CW

更新日期：2016-05-20 00:00:00

abstract：:The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...

journal_title：Scientific reports

authors： Thompson WH,Fransson P

更新日期：2016-12-19 00:00:00

abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...

journal_title：Scientific reports

authors： Reimann H,Stopper H,Polak T,Lauer M,Herrmann MJ,Deckert J,Hintzsche H

更新日期：2020-12-17 00:00:00

abstract：:Induction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the treatment outcomes and toxicities between two induction chemotherapy regimens, with both followed by concurrent chemoradiotherapy. The first strategy used docetaxel, cisplatin and fluorouraci...

journal_title：Scientific reports

authors： Zeng Z,Yan RN,Tu L,Wang YY,Chen PR,Luo F,Liu L

更新日期：2018-10-22 00:00:00

abstract：:Many insects possess the ability to detect fine fluctuations in the environmental CO2 concentration. In herbivorous species, plant-emitted CO2, in combination with other sensory cues, affect many behaviors including foraging and oviposition. In contrast to the comprehensive knowledge obtained on the insect olfactory p...

journal_title：Scientific reports

authors： Chu X,Kc P,Ian E,Kvello P,Liu Y,Wang GR,Berg BG

更新日期：2020-11-16 00:00:00

abstract：:Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...

journal_title：Scientific reports

authors： Scalzone A,Ferreira AM,Tonda-Turo C,Ciardelli G,Dalgarno K,Gentile P

更新日期：2019-10-10 00:00:00