Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica.

abstract：:HLA-haploidentical hematopoietic stem cell transplantation (HSCT) may be an option for severe aplastic anemia (SAA) patients. However, to date, no large-sample studies have been performed to determine which types of SAA patients are suitable for HLA-haploidentical HSCT. We retrospectively studied 189 consecutive patie...

journal_title：Scientific reports

authors： Zeng Y,Wang S,Wang J,Liu L,Su Y,Lu Z,Zhang X,Zhang Y,Zhong JF,Peng L,Liu Q,Lu Y,Gao L,Zhang X

更新日期：2018-02-06 00:00:00

abstract：:Habitat degradation is among the top drivers of the loss of global biodiversity. This problem is particularly acute in coral reef system. Here we investigated whether coral degradation influences predator risk assessment and learning for damselfish. When in a live coral environment, Ambon damselfish were able to learn...

journal_title：Scientific reports

authors： Chivers DP,McCormick MI,Allan BJ,Ferrari MC

更新日期：2016-09-09 00:00:00

abstract：:B-cell receptor (BCR) signaling plays a critical role in B-cell activation and humoral immunity. In this study, we discovered a critical function of leucine-rich repeat kinase 1 (LRRK1) in BCR-mediated immune responses. Lrrk1(-/-) mice exhibited altered B1a-cell development and basal immunoglobulin production. In addi...

journal_title：Scientific reports

authors： Morimoto K,Baba Y,Shinohara H,Kang S,Nojima S,Kimura T,Ito D,Yoshida Y,Maeda Y,Sarashina-Kida H,Nishide M,Hosokawa T,Kato Y,Hayama Y,Kinehara Y,Okuno T,Takamatsu H,Hirano T,Shima Y,Narazaki M,Kurosaki T,Toyofuku

更新日期：2016-05-11 00:00:00

abstract：:Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity...

journal_title：Scientific reports

authors： Zhang YF,Ho M

更新日期：2016-09-26 00:00:00

abstract：:Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites were synthesised by co-precipitating iron salts onto GO sheets in basic solution. The results showed that formation of two distinct structures was dependent upon the GO loading. The first structure corresponds to a low GO loading up to 10 wt%, associated with the ben...

journal_title：Scientific reports

authors： Zubir NA,Yacou C,Motuzas J,Zhang X,Diniz da Costa JC

更新日期：2014-04-04 00:00:00

abstract：:This cross-sectional study aimed to investigate the prevalence and risk factors of chronic kidney disease (CKD) among 1,096 primary care type 2 diabetes (T2DM) patients in northern Thailand between October 2016 and September 2017. CKD was defined as estimated glomerular rate filtration values of <60 mL/min/1.73 m2. Pr...

journal_title：Scientific reports

authors： Jitraknatee J,Ruengorn C,Nochaiwong S

更新日期：2020-04-10 00:00:00

abstract：:Cardiomyocytes differentiated from human pluripotent stem cells provide promising tools for screening of cardiotoxic drugs. For evaluation of human pluripotent stem cell-derived cardiomyocytes for cardiotoxicity test, in the present study, human embryonic stem cells (hESCs) were differentiated to cardiomyocytes, follo...

journal_title：Scientific reports

authors： Kim HS,Yoon JW,Li H,Jeong GO,Park JJ,Shin SE,Jang IH,Kim JH,Park WS

更新日期：2017-10-23 00:00:00

abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...

journal_title：Scientific reports

authors： Blanco JL,Porto-Pazos AB,Pazos A,Fernandez-Lozano C

更新日期：2018-10-24 00:00:00

abstract：:Transgenic plants producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) are useful for pest control, but their efficacy is reduced when pests evolve resistance. Here we examined the mechanism of resistance to Bt toxin Cry1Ac in the laboratory-selected LF5 strain of the cotton bollworm, Helicov...

journal_title：Scientific reports

authors： Liu C,Xiao Y,Li X,Oppert B,Tabashnik BE,Wu K

更新日期：2014-11-27 00:00:00

abstract：:The brain-derived neurotrophic factor (BDNF) protein is essential for neuronal development. Val66Met (rs6265) is a functional polymorphism at codon 66 of the BDNF gene that affects neuroplasticity and has been associated with cognition, brain structure and function. The aim of this study was to clarify the relationshi...

journal_title：Scientific reports

authors： Roy N,Barry RJ,Fernandez FE,Lim CK,Al-Dabbas MA,Karamacoska D,Broyd SJ,Solowij N,Chiu CL,Steiner GZ

更新日期：2020-10-21 00:00:00

abstract：:Recent decades have experienced the discovery of numerous complex materials. At the root of the complexity underlying many of these materials lies a large number of contending atomic- and largerscale configurations. In order to obtain a more detailed understanding of such systems, we need tools that enable the detecti...

journal_title：Scientific reports

authors： Ronhovde P,Chakrabarty S,Hu D,Sahu M,Sahu KK,Kelton KF,Mauro NA,Nussinov Z

更新日期：2012-01-01 00:00:00

abstract：:Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome At...

journal_title：Scientific reports

authors： Guo L,Zhang Q,Ma X,Wang J,Liang T

更新日期：2017-01-03 00:00:00

abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...

journal_title：Scientific reports

authors： Chang WM,Lin YF,Su CY,Peng HY,Chang YC,Hsiao JR,Chen CL,Chang JY,Shieh YS,Hsiao M,Shiah SG

更新日期：2017-01-25 00:00:00

abstract：:Species are chronically exposed to ionizing radiation, a natural phenomenon which can be enhanced by human activities. The induced toxicity mechanisms still remain unclear and seem depending on the mode of exposure, i.e. acute and chronic. To better understand these phenomena, studies need to be conducted both at the ...

journal_title：Scientific reports

authors： Dubois C,Lecomte C,Ruys SPD,Kuzmic M,Della-Vedova C,Dubourg N,Galas S,Frelon S

更新日期：2018-07-27 00:00:00

abstract：:The dispersal of animals from their birth place has profound effects on the immediate survival and longer-term persistence of populations. Molecular studies have estimated that bumblebee colonies can be established many kilometers from their queens' natal nest site. However, little is known about when and how queens d...

journal_title：Scientific reports

authors： Makinson JC,Woodgate JL,Reynolds A,Capaldi EA,Perry CJ,Chittka L

更新日期：2019-03-20 00:00:00

abstract：:With limited success achieved in bladder cancer patient management, novel agents are in urgent need for the purpose of therapy and prevention. As a sesquiterpenoid dimmer isolated from Gochnatia pomculat, (-)-gochnatiolide B has been bio-mimetically synthesized in multiple steps with a poor yield, which heavily limite...

journal_title：Scientific reports

authors： Chen Y,Li W,Zeng Z,Tang Y

更新日期：2018-06-11 00:00:00

abstract：:Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients a...

journal_title：Scientific reports

authors： Pirraglia MP,Ceccarelli G,Cerini A,Visioli G,d'Ettorre G,Mastroianni CM,Pugliese F,Lambiase A,Gharbiya M

更新日期：2020-10-15 00:00:00

abstract：:Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

journal_title：Scientific reports

authors： Lazzerini GM,Strambini LM,Barillaro G

更新日期：2013-01-01 00:00:00

abstract：:Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...

journal_title：Scientific reports

authors： Obryk MK,Fountain AG,Doran PT,Lyons WB,Eastman R

更新日期：2018-03-22 00:00:00

abstract：:Ring-opening graft polymerization (ROGP) of L-Lactide (L-LA) is a practical method of altering the physical and chemical properties of lignocellulose. Previous studies have mainly investigated cellulose and tin-based catalysts, particularly of tin(II) 2-ethylhexanoate (Sn(oct)2), at high temperatures and reported low ...

journal_title：Scientific reports

authors： Zhang X,Wang H,Liu C,Zhang A,Ren J

更新日期：2017-04-03 00:00:00

abstract：:Flat optics, which could planarize and miniaturize the traditional optical elements, possesses the features of extremely low profile and high integration for advanced manipulation of light. Here we proposed and experimentally demonstrated a planar metalens to realize an ultra-long focal length of ~240λ with a large de...

journal_title：Scientific reports

authors： Qin F,Huang K,Wu J,Jiao J,Luo X,Qiu C,Hong M

更新日期：2015-05-06 00:00:00

abstract：:With the reduction of oil and gas reserves and the increase of mining difficulty in Northern China, the carbonate rocks in Southern North China Basin are becoming a significant exploration target for carbonate reservoirs. However, the development characteristics, formation stages, formation environments and mechanisms...

journal_title：Scientific reports

authors： Zhang H,Xu G,Liu M,Wang M

更新日期：2021-01-12 00:00:00

abstract：:Parent selection is the core of hybrid breeding. The breeding strategy involving the parental identification of superior open-pollinated progeny of Populous tomentosa germplasm resources can significantly improve the efficiency of parental matching. However, due to some factors such as loose powdering time and pollen ...

journal_title：Scientific reports

authors： Han Z,Han Q,Xia Y,Geng X,Du K,Yang J,Kang X

更新日期：2020-10-29 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have been developed to detect influenza A virus for the swift diagnosis and management of patients. However, despite the simplicity and convenience, the low sensitivity of RDTs remains a limitation for their use in point of care testing (POCT). In this study, we developed a rapid fluoresc...

journal_title：Scientific reports

authors： Yu ST,Thi Bui C,Kim DTH,V T Nguyen A,Thi Trinh TT,Yeo SJ

更新日期：2018-09-07 00:00:00

abstract：:Metastatic colorectal cancer is the fourth most common cause of cancer death. Current options in palliation such as hyperthermic intraperitoneal chemotherapy (HIPEC) present severe side effects. Recent research efforts suggested the therapeutic use of oxidant-enriched liquid using cold physical plasma. To investigate ...

journal_title：Scientific reports

authors： Freund E,Liedtke KR,van der Linde J,Metelmann HR,Heidecke CD,Partecke LI,Bekeschus S

更新日期：2019-01-24 00:00:00

abstract：:Spatially explicit information on electric power consumption (EPC) is crucial for effective electricity allocation and utilization. Many studies have estimated fine-scale spatial EPC based on remotely sensed nighttime light (NTL). However, the spatial non-stationary relationship between EPC and NTL at prefectural leve...

journal_title：Scientific reports

authors： Chen M,Cai H,Yang X,Jin C

更新日期：2020-10-29 00:00:00

abstract：:Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...

journal_title：Scientific reports

authors： Patrono D,Surra A,Catalano G,Rizza G,Berchialla P,Martini S,Tandoi F,Lupo F,Mirabella S,Stratta C,Salizzoni M,Romagnoli R

更新日期：2019-06-27 00:00:00

abstract：:The microtubule cytoskeleton is composed of α-tubulin and β-tubulin heterodimers, and it serves to regulate the shape, motility, and division of a cell. Post-translational modifications including acetylation are closely associated with the functional aspects of the microtubule, involving in a number of pathological di...

journal_title：Scientific reports

authors： Han SJ,Kim JH,Kim JI,Park KM

更新日期：2016-06-08 00:00:00

abstract：:We propose a novel method to achieve tunable plasmon focusing in graphene/photonic-crystal hybrid structure exhibiting all-angle negative refraction at terahertz frequencies. A two-dimensional photonic crystal composed of a square lattice of dielectric rods is constructed on the substrate of a graphene sheet to provid...

journal_title：Scientific reports

authors： Zhong S,Lu Y,Li C,Xu H,Shi F,Chen Y

更新日期：2017-02-02 00:00:00

abstract：:In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of crucial importance. We demonstrated that Regulated in development and DNA damage r...

journal_title：Scientific reports

authors： Pastor F,Dumas K,Barthélémy MA,Regazzetti C,Druelle N,Peraldi P,Cormont M,Tanti JF,Giorgetti-Peraldi S

更新日期：2017-08-01 00:00:00