Abstract：
:Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneously transplanting them into immunodeficient mice did not generate teratomas. In this study, we applied KP-1 to analyze mouse ES (mES) cells and mouse iTS-P (miTS-P) cells. KP-1 completely stained mES cells in colonies, but only miTS-P cells at the edge of a colony. This difference was caused by cell type-specific expression of different ABC transporters. These finding suggest that KP-1 will be useful for distinguishing between iPS and iTS-P cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Miyagi-Shiohira C,Saitoh I,Watanabe M,Noguchi Hdoi
10.1038/s41598-020-75016-6subject
Has Abstractpub_date
2020-10-22 00:00:00pages
18084issue
1issn
2045-2322pii
10.1038/s41598-020-75016-6journal_volume
10pub_type
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