Abstract：
:The overuse of antibiotics results in the development of antibiotic resistance and limits the useful life of these drugs in fighting bacteria, including Aeromonas hydrophila, a well-known opportunistic pathogen that causes serious infections in fish and other animals. In this study, we investigated the adaptive resistance mechanism in A. hydrophila by multiple proteomic methods. Dimethyl labeling and label-free methods were performed to compare the differential expression of proteins in response to various doses of oxytetracycline (OXY). The results point to the conclusions that, in response to OXY stress, translational processes increase the abundance of these proteins whereas largely central metabolic pathways decrease their abundance. To confirm our hypothesis, various exogenous metabolites were compounded with OXY, and the resulting survival capabilities were measured. Results show that 7 metabolites (malic acid, serine, methionine, etc.) significantly decreased the survival capabilities of A. hydrophila in the presence of OXY, whereas 4 metabolites (arginine, lysine, tyrosine, etc.) did the opposite. Further investigation suggests that a compound comprising exogenous metabolites in combination with various antibiotics could have a significant bactericidal effect and might come into widespread use, especially together with tetracycline antibiotics. These findings may provide new clues to the antimicrobial treatment of A. hydrophila infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yao Z,Li W,Lin Y,Wu Q,Yu F,Lin W,Lin Xdoi
10.1038/srep39413subject
Has Abstractpub_date
2016-12-19 00:00:00pages
39413issn
2045-2322pii
srep39413journal_volume
6pub_type
杂志文章abstract：:Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing a series of developmental changes. During differentiation, the trypanosome alters its prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22451
更新日期：2016-03-02 00:00:00
abstract：:With the development of next generation sequencing, more and more common inherited diseases have been reported. However, accurate and convenient molecular diagnosis cannot be achieved easily because of the enormous size of disease causing mutations. In this study, we introduced a new single-step method for the genetic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30151-z
更新日期：2018-08-03 00:00:00
abstract：:Understanding the processes that shaped contemporary pathogen populations in agricultural landscapes is quite important to define appropriate management strategies and to support crop improvement efforts. Here, we took advantage of an historical record to examine the adaptation pathway of the rice pathogen Xanthomonas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34137
更新日期：2016-09-26 00:00:00
abstract：:Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68617-8
更新日期：2020-08-14 00:00:00
abstract：:In recent years methicillin-resistant Staphylococcus aureus has posed a challenge in treating skin and soft tissue infections. Finding new antimicrobial agents has therefore become imperative. We evaluated the in vitro antimicrobial activity of a synthetic peptide, P6, against multidrug resistant clinical strains of S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53926-4
更新日期：2019-11-20 00:00:00
abstract：:Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described as a general problem of the latest Illumina sequencing instruments utilizing exclusion amplifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23563-4
更新日期：2018-03-28 00:00:00
abstract：:Synthetic fertilizer production is associated with a high environmental footprint, as compounds typically dissolve rapidly leaching emissions to the atmosphere or surface waters. We tested two recovered nutrients with slower release patterns, as promising alternatives for synthetic fertilizers: struvite and a commerci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45290-0
更新日期：2019-07-02 00:00:00
abstract：:Coupling between dynamical heterogeneity of ionic liquids and their structural periodicity on different length-scales can be directly probed by quasielastic neutron scattering with polarization analysis. The technique provides the tools to investigate single-particle and cooperative ion motions separately and, thus, d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34481-w
更新日期：2018-11-06 00:00:00
abstract：:Silicon nanocrystals offer huge advantages compared to other semi-conductor quantum dots as they are made from an abundant, non-toxic material and are compatible with silicon devices. Besides, among a wealth of extraordinary properties ranging from catalysis to nanomedicine, metal nanoparticles are known to increase t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02672
更新日期：2013-01-01 00:00:00
abstract：:Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26578
更新日期：2016-05-25 00:00:00
abstract：:Conversion of lignocellulosic biomass to biofuels and biomaterials suffers from high production costs associated with biomass pretreatment and enzymatic hydrolysis. In-planta expression of lignocellulose-digesting enzymes is a promising approach to reduce these cost elements. However, this approach faces a number of c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11026-1
更新日期：2017-09-13 00:00:00
abstract：:A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05047-z
更新日期：2017-07-06 00:00:00
abstract：:Although macrophages are important players in the injury/repair processes in animal models of acute kidney injury (AKI), their roles in human AKI remains uncertain owing to a paucity of human biopsy studies. We investigated the role of macrophages in 72 cases of biopsy-proven acute tubular necrosis (ATN) and six cases...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58725-w
更新日期：2020-02-07 00:00:00
abstract：:When sliding our fingertip against a textured surface, complex vibrations are produced in the skin. It is increasingly recognised that the neural transduction and processing of these vibrations plays an important role in the dynamic tactile perception of textures. The aim of the present study was to develop a novel me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20738
更新日期：2016-02-08 00:00:00
abstract：:Evolutions of Asian and Australian monsoons have important significance for understanding the past global change but are still a controversial subject. Here, we explore systematically the effects of plate movement and plateau uplift on the formation and evolution of the Asian and Australian monsoons by numerical simul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40344
更新日期：2017-01-13 00:00:00
abstract：:Periodontitis is a multifactorial inflammatory disease that can cause tooth loss and contribute to systemic inflammation. It is suggested that periodontitis may be associated with the development of glaucoma. Based on data from Taiwan's National Health Insurance Research Database, a retrospective cohort study was cond...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74589-6
更新日期：2020-10-16 00:00:00
abstract：:The natural peptide chensinin-1 doesnot exhibit its desired biological properties. In this study, the mutant MC1-1 was designed by replacing Gly in the chensinin-1 sequence with Trp. Mutants MC1-2 and MC1-3 were designed based on the MC1-1 sequence to investigate the specific role of His residues. The mutated peptides...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40228
更新日期：2017-01-05 00:00:00
abstract：:The study of cancer immunology has provided diagnostic and therapeutic instruments through serum autoantibody biomarkers and exogenous monoclonal antibodies. While some endogenous antibodies are found within or surrounding transformed tissue, the extent to which this exists has not been entirely characterized. We find...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05088
更新日期：2014-05-30 00:00:00
abstract：:Western wheatgrass (Pascopyrum smithii Rydb.) is an important cool-season forage and turfgrass. However, due to seed dormancy and poor seedling vigor, it is difficult to develop high seed yield production systems, and assessing these components in response to seed yield. Based on multifactor orthogonally designed fiel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54586-0
更新日期：2019-11-29 00:00:00
abstract：:Since the re-emergence of Zika virus in 2014 and subsequent association with microcephaly, much work has focused on the development of a vaccine to halt its spread throughout the world. The mosquito vector that transmits this virus is widespread and responsible for the spread of other arboviridae including Dengue. Cur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05980-z
更新日期：2017-07-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-31524-0
更新日期：2018-09-03 00:00:00
abstract：:Geographical origin determination of white rice has become the major issue of food industry. However, there is still lack of a high-throughput method for rapidly and reproducibly differentiating the geographical origins of commercial white rice. In this study, we developed a method that employed lipidomics and deep le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08892-0
更新日期：2017-08-17 00:00:00
abstract：:Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-52436-7
更新日期：2019-11-01 00:00:00
abstract：:The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54057-6
更新日期：2019-11-26 00:00:00
abstract：:Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16363-9
更新日期：2017-12-12 00:00:00
abstract：:Radix Astragali is commonly used in traditional Chinese medicine, and its quality is closely related to ecological factors, such as climate and soil, in the production area. To provide high-quality Radix Astragali to Chinese and foreign markets, we used maximum entropy model and statistical analysis method, combined w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69391-3
更新日期：2020-07-27 00:00:00
abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32038
更新日期：2016-08-25 00:00:00
abstract：:Combined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21152-z
更新日期：2018-02-09 00:00:00
abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72062-y
更新日期：2020-09-16 00:00:00
abstract：:We show that filamentous fungi can emit green or red light after the accumulation of particulate lanthanide metal-organic frameworks over the cell wall. These new biohybrids present photoluminescence properties that are unaffected by the components of the cell wall. In addition, the fungal cells internalise lanthanide...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43835-x
更新日期：2019-05-13 00:00:00
