Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.

Abstract:

:Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Belmans N,Gilles L,Vermeesen R,Virag P,Hedesiu M,Salmon B,Baatout S,Lucas S,Lambrichts I,Jacobs R,Moreels M,DIMITRA Research Group.

doi

10.1038/s41598-020-58746-5

subject

Has Abstract

pub_date

2020-02-07 00:00:00

pages

2113

issue

1

issn

2045-2322

pii

10.1038/s41598-020-58746-5

journal_volume

10

pub_type

杂志文章
  • Sea-level rise induced amplification of coastal protection design heights.

    abstract::Coastal protection design heights typically consider the superimposed effects of tides, surges, waves, and relative sea-level rise (SLR), neglecting non-linear feedbacks between these forcing factors. Here, we use hydrodynamic modelling and multivariate statistics to show that shallow coastal areas are extremely sensi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40171

    authors: Arns A,Dangendorf S,Jensen J,Talke S,Bender J,Pattiaratchi C

    更新日期:2017-01-06 00:00:00

  • Sulfuric acid intercalated graphite oxide for graphene preparation.

    abstract::Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03439

    authors: Hong Y,Wang Z,Jin X

    更新日期:2013-12-06 00:00:00

  • Iterative consensus spectral clustering improves detection of subject and group level brain functional modules.

    abstract::Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63552-0

    authors: Gupta S,Rajapakse JC

    更新日期:2020-05-05 00:00:00

  • A Data Driven Model for Predicting RNA-Protein Interactions based on Gradient Boosting Machine.

    abstract::RNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27814-2

    authors: Jain DS,Gupte SR,Aduri R

    更新日期:2018-06-22 00:00:00

  • Prevalence of Integrase Strand Transfer Inhibitors (INSTI) Resistance Mutations in Taiwan.

    abstract::Antiretroviral therapy containing an integrase strand transfer inhibitor (INSTI) plus two NRTIs has become the recommended treatment for antiretroviral-naive HIV-1-infected patients in the updated guidelines. We aimed to determine the prevalence of INSTI-related mutations in Taiwan. Genotypic resistance assays were pe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35779

    authors: Chang SY,Lin PH,Cheng CL,Chen MY,Sun HY,Hsieh SM,Sheng WH,Su YC,Su LH,Chang SF,Liu WC,Hung CC,Chang SC

    更新日期:2016-10-25 00:00:00

  • Regulation of PCGEM1 by p54/nrb in prostate cancer.

    abstract::PCGEM1 is a long non-coding RNA (lncRNA) that is often upregulated in prostate cancer. However, little is known how PCGEM1 is regulated. In the present study, we show transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. While ectopic expression of p54/nrb increases, suppression of p54/n...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34529

    authors: Ho TT,Huang J,Zhou N,Zhang Z,Koirala P,Zhou X,Wu F,Ding X,Mo YY

    更新日期:2016-09-29 00:00:00

  • Excited-state fidelity as a signal for the many-body localization transition in a disordered Ising chain.

    abstract::In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transitions in quantum Ising chains with disordered nearest-neighbour couplings, disordered next-nearest-neighbour couplings and disordered external fields. It is demonstrated that the fidelity can be used to characterize the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00660-4

    authors: Hu T,Xue K,Li X,Zhang Y,Ren H

    更新日期:2017-04-03 00:00:00

  • Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving.

    abstract::Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60940-4

    authors: Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

    更新日期:2020-03-05 00:00:00

  • Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population.

    abstract::Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58430-8

    authors: Otto L,Budde K,Kastenmüller G,Kaul A,Völker U,Völzke H,Adamski J,Kühn JP,Krumsiek J,Artati A,Nauck M,Friedrich N,Pietzner M

    更新日期:2020-01-30 00:00:00

  • Bacterial community structure and function shift along a successional series of tidal flats in the Yellow River Delta.

    abstract::Coastal ecosystems play significant ecological and economic roles but are threatened and facing decline. Microbes drive various biogeochemical processes in coastal ecosystems. Tidal flats are critical components of coastal ecosystems; however, the structure and function of microbial communities in tidal flats are poor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36550

    authors: Lv X,Ma B,Yu J,Chang SX,Xu J,Li Y,Wang G,Han G,Bo G,Chu X

    更新日期:2016-11-08 00:00:00

  • Anatomical Study of the Neurovascular in Flexor Hallucis Longus Tendon Transfers.

    abstract::The transfer of the flexor hallucis longus tendon or flexor digitorum longus tendon is frequently used for the treatment of posterior tibial tendon insufficiency or chronic Achilles tendinopathy. According to several anatomical studies, harvesting the flexor hallucis longus (FHL) tendon may cause nerve injury. Sixty-e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13742-0

    authors: Mao H,Dong W,Shi Z,Yin W,Xu D,Wapner KL

    更新日期:2017-10-27 00:00:00

  • Tailoring Mechanically Robust Poly(m-phenylene isophthalamide) Nanofiber/nets for Ultrathin High-Efficiency Air Filter.

    abstract::Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40550

    authors: Zhang S,Liu H,Yin X,Li Z,Yu J,Ding B

    更新日期:2017-01-11 00:00:00

  • Simultaneously improving the mechanical and electrical properties of poly(vinyl alcohol) composites by high-quality graphitic nanoribbons.

    abstract::Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties v...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17365-3

    authors: Yang M,Weng L,Zhu H,Zhang F,Fan T,Zhang D

    更新日期:2017-12-07 00:00:00

  • Multivariate analysis reveals significant diuron-related changes in the soil composition of different Brazilian regions.

    abstract::Sorption and desorption determine the amount of an herbicide in soil solution. Therefore, knowledge of the sorption and desorption coefficients in different soils is an essential factor to estimate the potential for environmental contamination by herbicides. We evaluated the feasibility of multivariate and linear disc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44405-x

    authors: Chagas PSFD,Souza MF,Dombroski JLD,Junior RSO,Nunes GHS,Pereira GAM,Silva TS,Passos ABRJ,Santos JBD,Silva DV

    更新日期:2019-05-27 00:00:00

  • Time Series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization.

    abstract::Polarization of macrophages is regulated through complex signaling networks. Correlating miRNA and mRNA expression over time after macrophage polarization has not yet been investigated. We used paired RNA-Seq and miRNA-Seq experiments to measure the mRNA and miRNA expression in bone marrow-derived macrophages over a t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37446

    authors: Lu L,McCurdy S,Huang S,Zhu X,Peplowska K,Tiirikainen M,Boisvert WA,Garmire LX

    更新日期:2016-12-16 00:00:00

  • Comparative transcriptome analysis of Eogammarus possjeticus at different hydrostatic pressure and temperature exposures.

    abstract::Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39716-y

    authors: Chen J,Liu H,Cai S,Zhang H

    更新日期:2019-03-05 00:00:00

  • A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval.

    abstract::Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04894

    authors: Shen JC,Fox EJ,Ahn EH,Loeb LA

    更新日期:2014-05-08 00:00:00

  • Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells.

    abstract::Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01525-6

    authors: Ietta F,Maioli E,Daveri E,Gonzaga Oliveira J,da Silva RJ,Romagnoli R,Cresti L,Maria Avanzati A,Paulesu L,Barbosa BF,Gomes AO,Roberto Mineo J,Ferro EAV

    更新日期:2017-04-28 00:00:00

  • Network rewiring is an important mechanism of gene essentiality change.

    abstract::Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the framework of network evolution and comparative genomic analysis. We foun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00900

    authors: Kim J,Kim I,Han SK,Bowie JU,Kim S

    更新日期:2012-01-01 00:00:00

  • Hard plant tissues do not contribute meaningfully to dental microwear: evolutionary implications.

    abstract::Reconstructing diet is critical to understanding hominin adaptations. Isotopic and functional morphological analyses of early hominins are compatible with consumption of hard foods, such as mechanically-protected seeds, but dental microwear analyses are not. The protective shells surrounding seeds are thought to induc...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/s41598-019-57403-w

    authors: van Casteren A,Strait DS,Swain MV,Michael S,Thai LA,Philip SM,Saji S,Al-Fadhalah K,Almusallam AS,Shekeban A,McGraw WS,Kane EE,Wright BW,Lucas PW

    更新日期:2020-01-17 00:00:00

  • Neurodevelopment and asymmetry of auditory-related responses to repetitive syllabic stimuli in preterm neonates based on frequency-domain analysis.

    abstract::Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47064-0

    authors: Daneshvarfard F,Abrishami Moghaddam H,Dehaene-Lambertz G,Kongolo G,Wallois F,Mahmoudzadeh M

    更新日期:2019-07-23 00:00:00

  • Identification and local manipulation of bone marrow vasculature during intravital imaging.

    abstract::Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63533-3

    authors: Morikawa T,Tamaki S,Fujita S,Suematsu M,Takubo K

    更新日期:2020-04-14 00:00:00

  • Hair organ regeneration via the bioengineered hair follicular unit transplantation.

    abstract::Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully functional regeneration of ectodermal organs, a concept has been proposed in which a bioengineered organ is developed by reproducing the embryoni...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00424

    authors: Asakawa K,Toyoshima KE,Ishibashi N,Tobe H,Iwadate A,Kanayama T,Hasegawa T,Nakao K,Toki H,Noguchi S,Ogawa M,Sato A,Tsuji T

    更新日期:2012-01-01 00:00:00

  • Photocatalytic dye degradation and antimicrobial activities of Pure and Ag-doped ZnO using Cannabis sativa leaf extract.

    abstract::A facile green route has been employed for the synthesis of ZnO and Ag-doped ZnO using Cannabis sativa as a reducing and stabilizing agent. The as-synthesized nanoparticles were characterized and tested for photocatalytic dye degradation and antimicrobial activity. The results suggested that nanoparticles have shown a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64419-0

    authors: Chauhan A,Verma R,Kumari S,Sharma A,Shandilya P,Li X,Batoo KM,Imran A,Kulshrestha S,Kumar R

    更新日期:2020-05-12 00:00:00

  • Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action.

    abstract::Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in the blood and are the first defense mechanism against S. aureus infections. Here we show Staphylococcal Superantigen-Like protein 11 (SSL...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40817-x

    authors: Chen C,Yang C,Barbieri JT

    更新日期:2019-03-12 00:00:00

  • Nanofluid based on self-nanoencapsulated metal/metal alloys phase change materials with tuneable crystallisation temperature.

    abstract::Nanofluids using nanoencapsulated Phase Change Materials (nePCM) allow increments in both the thermal conductivity and heat capacity of the base fluid. Incremented heat capacity is produced by the melting enthalpy of the nanoparticles core. In this work two important advances in this nanofluid type are proposed and ex...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17841-w

    authors: Navarrete N,Gimeno-Furio A,Mondragon R,Hernandez L,Cabedo L,Cordoncillo E,Julia JE

    更新日期:2017-12-14 00:00:00

  • Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.

    abstract::Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and basal-like tumors. With this approach we identified 16 ubiquitin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17836-7

    authors: Perez-Peña J,Corrales-Sánchez V,Amir E,Pandiella A,Ocana A

    更新日期:2017-12-13 00:00:00

  • Systematized reporter assays reveal ZIC protein regulatory abilities are Subclass-specific and dependent upon transcription factor binding site context.

    abstract::The ZIC proteins are a family of transcription regulators with a well-defined zinc finger DNA-binding domain and there is evidence that they elicit functional DNA binding at a ZIC DNA binding site. Little is known, however, regarding domains within ZIC proteins that confer trans-activation or -repression. To address t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69917-9

    authors: Ahmed JN,Diamand KEM,Bellchambers HM,Arkell RM

    更新日期:2020-08-04 00:00:00

  • Association between newborn screening analytes and hypoxic ischemic encephalopathy.

    abstract::Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. Our study sought to examine whether patterns of newborn screening analytes differed between infants with and without neonatal HIE in order to identify opportunities for potential use of these analytes for diagnosis in routine c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51919-x

    authors: Wilson LA,Fell DB,Hawken S,Wong CA,Murphy MSQ,Little J,Potter BK,Walker M,Lacaze-Masmonteil T,Juul S,Chakraborty P,Wilson K

    更新日期:2019-10-31 00:00:00

  • Kyoto probe-1 reveals phenotypic differences between mouse ES cells and iTS-P cells.

    abstract::Kyoto probe 1 (KP-1) rapidly distinguishes between human ES/iPS (hES/iPS) cells and their differentiated cells. Recently, we generated induced tissue-specific stem cells from pancreas (iTS-P cells) using reprogramming factors and tissue-specific selection. The iTS-P cells have self-renewal potential, and subcutaneousl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75016-6

    authors: Miyagi-Shiohira C,Saitoh I,Watanabe M,Noguchi H

    更新日期:2020-10-22 00:00:00