Abstract：
:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypic mammary model consisting of a collagen-embedded duct structure lined with MCF7 cells to 17-β estradiol (E2), with and without HMFs in the surrounding matrix. MCF7 cells grown as ductal structures were polarized and proliferated at rates comparable to in vivo breast tissue. In both culture platforms, exposure to E2 increased ER transactivation, increased proliferation, and induced ductal hyperplasia. When the surrounding matrix contained HMFs, the onset and severity of E2-induced ductal hyperplasia was increased due to decreased apoptosis. The reduced apoptosis may be due to fibroblasts modulating ER signaling in MCF7 cells, as suggested by the increased ER transactivation and reduced ER protein in MCF7 cells grown in co-culture. These findings demonstrate the utility of organotypic platforms when studying stromal:epithelial interactions, and add to existing literature that implicate the mammary microenvironment in ER + breast cancer progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Morgan MM,Livingston MK,Warrick JW,Stanek EM,Alarid ET,Beebe DJ,Johnson BPdoi
10.1038/s41598-018-25461-1subject
Has Abstractpub_date
2018-05-08 00:00:00pages
7139issue
1issn
2045-2322pii
10.1038/s41598-018-25461-1journal_volume
8pub_type
杂志文章abstract：:Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26198
更新日期：2016-05-17 00:00:00
abstract：:The Frasnian-Famennian boundary records one of the most catastrophic mass extinctions of the Phanerozoic Eon. Several possible causes for this extinction have been suggested, including extra-terrestrial impacts and large-scale volcanism. However, linking the extinction with these potential causes is hindered by the la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27847-7
更新日期：2018-06-22 00:00:00
abstract：:Interferometry-based online partial discharge (PD) monitor presented in this paper can detect the occurrence of PD sensitively, evaluate the peak value of the discharge inception voltage with random waveform and the damage extent relatively cost effectively. The interferograms affected by the PD are collected online. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76134-x
更新日期：2020-11-04 00:00:00
abstract：:It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13368-2
更新日期：2017-10-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-27850-y
更新日期：2018-06-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-36219-0
更新日期：2018-12-10 00:00:00
abstract：:Silver nanoparticles (AgNPs) have been extensively used and are considered as an emerging contaminant in the ocean. The environmental contamination of AgNPs is expected to increase greatly over time, and cetaceans, as the top ocean predators, will suffer the negative impacts of AgNPs. In the present study, we investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23737-0
更新日期：2018-04-04 00:00:00
abstract：:We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40247-9
更新日期：2019-03-06 00:00:00
abstract：:We report, for the first time, that the energy of femtosecond optical laser pulses, E, with relativistic intensities I > 10(21) W/cm(2) is efficiently converted to X-ray radiation, which is emitted by "hot" electron component in collision-less processes and heats the solid density plasma periphery. As shown by direct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13436
更新日期：2015-09-02 00:00:00
abstract：:Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. To assess the risks of CM-induced SJS/TEN with SOC, systematic review and meta-analysis were employed. Studies investigating associations between HLA geno...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-67610-5
更新日期：2020-06-29 00:00:00
abstract：:Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection of a number of cytokines directly ex vivo. However, for some cytokines this approach is suboptimal. Here, we report technical variations that allow the improved dete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16832-1
更新日期：2017-11-30 00:00:00
abstract：:Although TRAIL can directly induce cell death in some cancer cells, it appears that TRAIL resistance exists in many cancers. This study focuses on anti-cancer drugs for TRAIL-resistant head and neck cancer (HNC) to provide further progress toward effective cancer therapy. Results indicate in TRAIL-resistant HNC cells,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31039-8
更新日期：2018-08-21 00:00:00
abstract：:When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69098-5
更新日期：2020-07-22 00:00:00
abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14562
更新日期：2015-10-01 00:00:00
abstract：:Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06646-6
更新日期：2017-07-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28391-0
更新日期：2018-07-11 00:00:00
abstract：:Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06542
更新日期：2014-10-13 00:00:00
abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19010-5
更新日期：2018-01-31 00:00:00
abstract：:The abundance and diversity of bacteria in two types of ponds were investigated by quantitative PCR and Illumina MiSeq sequencing. The results revealed that the abundance of bacterial 16S rRNA genes in D ponds (with grass carp fed sudan grass) was significantly lower than that in E ponds (with grass carp fed commercia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35232
更新日期：2016-10-19 00:00:00
abstract：:The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling. We utilized functional magnetic resonance imaging on NaV1.8-deficient (NaV1.8-/-) compared with wildtype (WT) mice to identify brain struct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00524-x
更新日期：2017-04-03 00:00:00
abstract：:A low-bandgap acceptor (ITIC) was added to a binary system composed of a wide-bandgap polymer (PBT-OTT) and an acceptor (PC71BM) to increase the light harvesting efficiency of the associated organic solar cells (OSCs). A ternary blend OSC with an acceptor ratio of PC71BM:ITIC = 8:2 was found to exhibit a power convers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48306-x
更新日期：2019-08-19 00:00:00
abstract：:Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the α1A subunit of the P/Q-type voltage-gated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02554-x
更新日期：2017-05-31 00:00:00
abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26193
更新日期：2016-05-19 00:00:00
abstract：:We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21859-z
更新日期：2018-02-22 00:00:00
abstract：:Adaptation to new environmental stress is often associated with an alteration of one or more life history parameters. Insecticide resistant populations of insects often have reduced fitness relative to susceptible populations in insecticide free environments. Our previous work showed that three populations of bed bugs...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10807
更新日期：2015-06-03 00:00:00
abstract：:Fuelled by a desire for greater connectivity, networked systems now pervade our society at an unprecedented level that will affect it in ways we do not yet understand. In contrast, nature has already developed efficient networks that can instigate rapid response and consensus when key elements are stimulated. We prese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53942-4
更新日期：2019-11-26 00:00:00
abstract：:Insulin resistance is a major risk factor for metabolic diseases such as Type 2 diabetes. Although the underlying mechanisms of insulin resistance remain elusive, oxidative stress is a unifying driver by which numerous extrinsic signals and cellular stresses trigger insulin resistance. Consequently, we sought to under...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20104-x
更新日期：2018-01-29 00:00:00
abstract：:Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18894
更新日期：2016-01-07 00:00:00
abstract：:Traumatic brain injury (TBI) causes brain edema that induces increased intracranial pressure and decreased cerebral perfusion. Decompressive craniectomy has been recommended as a surgical procedure for the management of swollen brain and intracranial hypertension. Proper location and size of a decompressive craniectom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75479-7
更新日期：2020-10-29 00:00:00
abstract：:Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three differ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70894-2
更新日期：2020-08-18 00:00:00
