Scaling and correlation properties of RR and QT intervals at the cellular level.

Abstract:

:We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short- and long-term scaling exponents α1 and α2 of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim J,Shah D,Potapov I,Latukka J,Aalto-Setälä K,Räsänen E

doi

10.1038/s41598-019-40247-9

subject

Has Abstract

pub_date

2019-03-06 00:00:00

pages

3651

issue

1

issn

2045-2322

pii

10.1038/s41598-019-40247-9

journal_volume

9

pub_type

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