Vitamin D attenuates myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts through smad2/3 signaling pathway.

abstract：:Septic shock is associated with multiple injuries to organs and tissues. These events may induce the regenerative response of adult stem cells. However, little is known about how endogenous stem cells are modulated by sepsis. This study analyzed the circulation of hematopoietic stem cells (HSCs), endothelial progenito...

journal_title：Scientific reports

authors： Skirecki T,Mikaszewska-Sokolewicz M,Godlewska M,Dołęgowska B,Czubak J,Hoser G,Kawiak J,Zielińska-Borkowska U

更新日期：2019-03-01 00:00:00

abstract：:Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-l...

journal_title：Scientific reports

authors： Li W,Wang M,Zhu W,Qin Y,Huang Y,Chen X

更新日期：2016-09-28 00:00:00

abstract：:Micro-tube experiment has been implemented to understand the mechanisms of governing microcosmic fluid percolation and is extensively used in both fields of micro electromechanical engineering and petroleum engineering. The measured pressure difference across the microtube is not equal to the actual pressure differenc...

journal_title：Scientific reports

authors： Wang S,Liu P,Zhao H,Zhang Y

更新日期：2017-11-29 00:00:00

abstract：:Majority of novel X-ray crystal structures of proteins are currently solved using the anomalous diffraction signal provided by selenium after incorporation of selenomethionine instead of natural methionine by genetic engineering methods. However, selenium can be inserted into protein crystals in the form of selenourea...

journal_title：Scientific reports

authors： Luo Z

更新日期：2016-11-14 00:00:00

abstract：:Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays a...

journal_title：Scientific reports

authors： Huh SU,Lee GJ,Jung JH,Kim Y,Kim YJ,Paek KH

更新日期：2015-01-23 00:00:00

abstract：:Due to the increasing environmental impact of food production, carbon footprint as an indicator can guide farmland management. This study established a method and estimated the carbon footprint of grain production in China based on life cycle analysis (LCA). The results showed that grain production has a high carbon f...

journal_title：Scientific reports

authors： Zhang D,Shen J,Zhang F,Li Y,Zhang W

更新日期：2017-06-29 00:00:00

abstract：:Skin burns are a significant source of injury in both military and civilian sectors. They are especially problematic in low resource environments where non-fatal injuries can lead to high morbidity rates, prolonged hospitalization, and disability. These multifaceted wounds can be highly complex and must be quickly dia...

journal_title：Scientific reports

authors： Nguyen JQ,Marks HL,Everett T,Haire T,Carlsson A,Chan R,Evans CL

更新日期：2020-06-09 00:00:00

abstract：:Urban heat dome flow, which is also referred to as urban heat island circulation, is important for urban ventilation and pollutant transport between adjacent cities when the background wind is weak or absent. A "dome-shaped" profile can form at the upper boundary of the urban heat island circulation. The horizontal ex...

journal_title：Scientific reports

authors： Fan Y,Li Y,Bejan A,Wang Y,Yang X

更新日期：2017-09-15 00:00:00

abstract：:Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...

journal_title：Scientific reports

authors： Choi J,Yoon YN,Kim N,Park CS,Seol H,Park IC,Kim HA,Noh WC,Kim JS,Seong MK

更新日期：2020-01-20 00:00:00

abstract：:The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult huma...

journal_title：Scientific reports

authors： Dusart P,Fagerberg L,Perisic L,Civelek M,Struck E,Hedin U,Uhlén M,Trégouët DA,Renné T,Odeberg J,Butler LM

更新日期：2018-10-02 00:00:00

abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...

journal_title：Scientific reports

authors： Bansal C,Praveen SG,Kumaran JT,Chatterjee A

更新日期：2015-01-08 00:00:00

abstract：:YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...

journal_title：Scientific reports

authors： Singh A,Thakur M,Singh SK,Sharma LK,Chandra K

更新日期：2020-09-17 00:00:00

abstract：:Clogging of porous media by soft particles has become a subject of extensive research in the last years and the understanding of the clogging mechanisms is of great importance for process optimization. The rise in the utilization of microfluidic devices brought the possibility to simulate membrane filtration and perfo...

journal_title：Scientific reports

authors： Bouhid de Aguiar I,Meireles M,Bouchoux A,Schroën K

更新日期：2019-06-25 00:00:00

abstract：:Increasing evidence has confirmed that immunoglobulins (Igs) can be expressed in non-B cells. Our previous work demonstrated that mesangial cells and podocytes express IgA and IgG, respectively. The aim of this work was to reveal whether proximal tubular epithelial cells (PTECs) express Igs. High-throughput single-cel...

journal_title：Scientific reports

authors： Deng Z,Wang X,Liu Y,Tian X,Deng S,Sun Y,Wang S,Zheng D,Cui Z,Pan Y,A L,Yan H,Qiu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:Indoor simulation experiment was carried out to evaluate the formation and consumption rates of methane (CH4) in Xiangxi Bay of the Three Gorges Reservoir (TGR), China. The results show that both the CH4 formation and consumption rates were significantly positively correlated with temperature. CH4 efflux decreased wit...

journal_title：Scientific reports

authors： Wang C,Xiao S,Li Y,Zhong H,Li X,Peng F

更新日期：2014-03-24 00:00:00

abstract：:Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value < 5 × 10-8) with diabetic albuminuria, in Finnish individuals with t...

journal_title：Scientific reports

authors： Sandholm N,Haukka JK,Toppila I,Valo E,Harjutsalo V,Forsblom C,Groop PH

更新日期：2018-08-17 00:00:00

abstract：:HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory sample...

journal_title：Scientific reports

authors： Linster M,Do LAH,Minh NNQ,Chen Y,Zhe Z,Tuan TA,Tuan HM,Su YCF,van Doorn HR,Moorthy M,Smith GJD

更新日期：2018-05-01 00:00:00

abstract：:Numerous researchers have expressed concern over the emerging water scarcity issues around the globe. Economic water scarcity is severe in the developing countries; thus, the use of inexpensive wastewater treatment strategies can help minimize this issue. An abundant amount of laundry wastewater (LWW) is generated dai...

journal_title：Scientific reports

authors： Yaseen ZM,Zigale TT,Tiyasha,D RK,Salih SQ,Awasthi S,Tung TM,Al-Ansari N,Bhagat SK

更新日期：2019-12-10 00:00:00

abstract：:Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and has a high survival rate when properly managed. Prognosis is correlated with many factors such as age, gender, white blood cell (WBC) count, CD10, French-American-British (FAB) classification, and many others. Many of these factors are include...

journal_title：Scientific reports

authors： Kakaje A,Alhalabi MM,Ghareeb A,Karam B,Mansour B,Zahra B,Hamdan O

更新日期：2020-04-21 00:00:00

abstract：:During symbiosis, organisms use a range of metabolic and protein-based signals to communicate. Of these protein signals, one class is defined as 'effectors', i.e., small secreted proteins (SSPs) that cause phenotypical and physiological changes in another organism. To date, protein-based effectors have been described ...

journal_title：Scientific reports

authors： Plett JM,Yin H,Mewalal R,Hu R,Li T,Ranjan P,Jawdy S,De Paoli HC,Butler G,Burch-Smith TM,Guo HB,Ju Chen C,Kohler A,Anderson IC,Labbé JL,Martin F,Tuskan GA,Yang X

更新日期：2017-03-23 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive movement disturbances caused by the selective loss of dopamine (DA) neurons in the substantia nigra. Despite the identification of the causal mechanisms underlying the pathogenesis of PD, effective treatments remain elusive. In this s...

journal_title：Scientific reports

authors： Lee EH,Kim SM,Kim CH,Pagire SH,Pagire HS,Chung HY,Ahn JH,Park CH

更新日期：2019-09-20 00:00:00

abstract：:To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2 (Nrf2) to prevent diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice were given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for ...

journal_title：Scientific reports

authors： Xu Z,Wang S,Ji H,Zhang Z,Chen J,Tan Y,Wintergerst K,Zheng Y,Sun J,Cai L

更新日期：2016-07-26 00:00:00

abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...

journal_title：Scientific reports

authors： Ding H,Luo Y,Liu M,Huang J,Xu D

更新日期：2016-02-11 00:00:00

abstract：:We found that the coagulation and cytokine pathways were important mechanisms involve in the degeneration of intervertebral discs (IVD) using a microarray approach to analyze gene expression in different grades of specimens. Furthermore, using a cytokine/chemokine array, a significant increase in CXCL8 expression was ...

journal_title：Scientific reports

authors： Huang BR,Chen TS,Bau DT,Chuang IC,Tsai CF,Chang PC,Lu DY

更新日期：2017-08-17 00:00:00

abstract：:Understanding the innate immune response to vaccination is critical in vaccine design. Here, we studied blood innate myeloid cells after first and second immunization of cynomolgus macaques with the modified vaccinia virus Ankara. The inflammation at the injection site was moderate and resolved faster after the boost....

journal_title：Scientific reports

authors： Palgen JL,Tchitchek N,Elhmouzi-Younes J,Delandre S,Namet I,Rosenbaum P,Dereuddre-Bosquet N,Martinon F,Cosma A,Lévy Y,Le Grand R,Beignon AS

更新日期：2018-02-15 00:00:00

abstract：:The availability of genotyping assays has allowed the detailed evaluation of cattle genetic diversity worldwide. However, these comprehensive studies did not include some local European populations, including autochthonous Italian cattle. In this study, we assembled a large-scale, genome-wide dataset of single nucleot...

journal_title：Scientific reports

authors： Mastrangelo S,Tolone M,Ben Jemaa S,Sottile G,Di Gerlando R,Cortés O,Senczuk G,Portolano B,Pilla F,Ciani E

更新日期：2020-09-03 00:00:00

abstract：:Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared vide...

journal_title：Scientific reports

authors： Scharbarg E,Daenens M,Lemaître F,Geoffroy H,Guille-Collignon M,Gallopin T,Rancillac A

更新日期：2016-01-12 00:00:00

abstract：:The treatment of testicular cancer includes unilateral orchiectomy and chemotherapy and is curative for most patients. However, observational studies revealed an association with depression, anxiety and cognitive impairment. It is unclear whether these side effects are caused by chemotherapy, hemicastration or the dis...

journal_title：Scientific reports

authors： Borbélyová V,Renczés E,Chovanec M,Mego M,Celec P

更新日期：2020-06-23 00:00:00

abstract：:Previously, we demonstrated that chronic exposure to low levels of estradiol-17β (E2) increases mean arterial pressure (MAP) in young female Sprague-Dawley (SD) rats, however, the underlying mechanisms are unclear. Since endothelin-1 (ET-1) is implicated in blood pressure (BP) regulation, we hypothesized that E2's eff...

journal_title：Scientific reports

authors： Subramanian M,MohanKumar SM,Balasubramanian P,Northcott CA,Garver H,Fink GD,MohanKumar PS

更新日期：2017-03-10 00:00:00

abstract：:Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) exacerbates early brain injury (EBI) following subarachnoid hemorrhage (SAH) by provoking pro-inflammatory and pro-apoptotic signaling. Myeloid differentiation primary response protein 88 (...

journal_title：Scientific reports

authors： Yan H,Zhang D,Wei Y,Ni H,Liang W,Zhang H,Hao S,Jin W,Li K,Hang CH

更新日期：2017-11-17 00:00:00