Abstract:
:Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and has a high survival rate when properly managed. Prognosis is correlated with many factors such as age, gender, white blood cell (WBC) count, CD10, French-American-British (FAB) classification, and many others. Many of these factors are included in this study as they play a major role in establishing the best treatment protocol. This study aims to demonstrate clinical and laboratory features of childhood ALL in Syria. They were treated at Children's University Hospital, the only working major cancer centre in Syria at the time of the study. Data of 203 patients who aged 0-14 years were obtained for this study. Most patients (48.8%) aged (5-9) years with a male predominance (60.9%). The major features for ALL included lymphadenopathy (82.9%), presenting with systemic symptoms (74.9%), T-ALL subclass (20.2%), L2 FAB classification (36.1%), low educational levels for fathers (53%) and mothers (56.2%), having a high risk (48.4%), and having a duration of symptoms before evaluation for more than 4 weeks (42.6%). Only three (1.5%) patients had normal full blood counts (FBC) and only one (0.5%) patient had an isolated high WBC count at time of presentation. Most patients had either abnormal platelet count (89.3%) or low haemoglobin level (88.8%) when presenting with only (2.0%) having normal levels for both. This suggests that having normal haemoglobin and platelet count can be used for quick screening in crisis time like in Syria for prioritising patients. Many prognostic factors were significantly different from medical literature which emphasises the importance of local studies in the developping countries. This study included a high prevalence of T-all, L2 FAB classification, high-risk and other variables which require further studies to evaluate the aetiology of these features, especially that treatment protocols may have a higher mortality in developing countries when not adjusted to local variables.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kakaje A,Alhalabi MM,Ghareeb A,Karam B,Mansour B,Zahra B,Hamdan Odoi
10.1038/s41598-020-63528-0subject
Has Abstractpub_date
2020-04-21 00:00:00pages
6756issue
1issn
2045-2322pii
10.1038/s41598-020-63528-0journal_volume
10pub_type
杂志文章abstract::This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42132-x
更新日期:2019-04-04 00:00:00
abstract::The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has gr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41999
更新日期:2017-02-06 00:00:00
abstract::In this work we revisit the important and controversial concept of quantum weak values, aiming to provide a simplified understanding to its associated physics and the origin of anomaly. Taking the Stern-Gerlach setup as a working system, we base our analysis on an exact treatment in terms of quantum Bayesian approach....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20286
更新日期:2016-02-03 00:00:00
abstract::Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35148-2
更新日期:2018-11-12 00:00:00
abstract::Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78328-9
更新日期:2020-12-10 00:00:00
abstract::A frequency reconfigurable dipole antenna based on a silicon radiator is presented. The silicon radiator is activated with the aid of highly dense solid-state plasma by injecting carriers into the intrinsic region of p-i-n diodes. The fabrication and design guideline of the reconfigurable dipole antenna with this plas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33278-1
更新日期:2018-10-09 00:00:00
abstract::Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38770
更新日期:2016-12-09 00:00:00
abstract::We study a three-mode (i.e., a clockwise mode, a counterclockwise mode, and a mechanical mode) coherent coupling regime of the optical whispering-gallery-mode (WGM) microresonator optomechanical system by considering a pair of counterpropagating modes in a general case. The WGM microresonator is coherently driven by a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39781
更新日期:2017-01-03 00:00:00
abstract::Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45504-5
更新日期:2019-06-24 00:00:00
abstract::Charge density wave (CDW), the periodic modulation of the electronic charge density, will open a gap on the Fermi surface that commonly leads to decreased or vanishing conductivity. On the other hand superconductivity, a commonly believed competing order, features a Fermi surface gap that results in infinite conductiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26974
更新日期:2016-06-02 00:00:00
abstract::Frequent self-monitoring of blood glucose (SMBG) is the only accurate method available for insulin dose titration in patients with T1DM. Professional continuous glucose monitoring (p-CGM) is blinded recording of glucose trends over 5-7 days and helps physicians to guide insulin titration to patient. This study was pla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42555-6
更新日期:2019-04-16 00:00:00
abstract::Mammals typically keep their body temperature (Tb) within a narrow limit with changing environmental conditions. There are indications that some wild ungulates can exhibit certain forms of energy saving mechanisms when ambient temperatures are low and/or food is scarce. Therefore, the aim of the study was to determine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07946-7
更新日期:2017-08-08 00:00:00
abstract::Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10878-x
更新日期:2017-09-06 00:00:00
abstract::p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46949-4
更新日期:2019-07-17 00:00:00
abstract::Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant enterococci (VRE), are among the pathogens that require new antibiotic innovation. The colonization of the gut represents a major pathway by which VRE can cause infection and spread to other patients. In the current study, auranofin (FDA-appro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26674-0
更新日期:2018-05-29 00:00:00
abstract::Yield-phenology relation is a critical issue affecting rainfed maize field productivity in semiarid east African Plateau (EAP). We first introduced Chinese ridge-furrow mulching (RFM) system to EAP, using three maize cultivars with early-, mid- and late-maturing traits as test materials. A two-year field experiment wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03372-x
更新日期:2017-06-12 00:00:00
abstract::Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34699-8
更新日期:2018-11-13 00:00:00
abstract::Developing optically transparent magnets at room temperature is an important challenge. They would bring many innovations to various industries, not only for electronic and magnetic devices but also for optical applications. Here we introduce FeCo-(Al-fluoride) nanogranular films exhibiting ferromagnetic properties wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34227
更新日期:2016-09-28 00:00:00
abstract::The development of microstructure during melting, reactive wetting and solidification of solder pastes on Cu-plated printed circuit boards has been studied by synchrotron radiography. Using Sn-3.0Ag-0.5Cu/Cu and Sn-0.7Cu/Cu as examples, we show that the interfacial Cu6Sn5 layer is present within 0.05 s of wetting, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40010
更新日期:2017-01-12 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22719-6
更新日期:2018-03-20 00:00:00
abstract::Muscle damage and loss of muscle mass are triggered by immobilization, loss of appetite, dystrophies and chronic wasting diseases. In addition, physical exercise causes muscle damage. In damaged muscle, the N-terminal and C-terminal regions of titin, a giant sarcomere protein, are cleaved by calpain-3, and the resulti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39375
更新日期:2016-12-19 00:00:00
abstract::Glomerular permeability and subsequent albuminuria are early clinical markers for glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and cardiovascular morbidity. AT1 receptor blockers protect from albuminuria, cardiovascular morbidity and mortality. A blood pressure independent, molecular m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39513
更新日期:2016-12-22 00:00:00
abstract::In order to improve the accuracy and reliability of micropipetting, a method of micro-pipette detection and calibration combining the dynamic pressure monitoring in pipetting process and quantitative identification of pipette volume in image processing was proposed. Firstly, the normalized pressure model for the pipet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24145-0
更新日期:2018-04-10 00:00:00
abstract::The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26052-w
更新日期:2018-05-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-77348-9
更新日期:2020-11-18 00:00:00
abstract::We experimentally investigate a discharging flux of granular particles through a sieve plate subject to vertical vibrations. The mean mass flux shows a non-monotonic relation with the vibration strength. High-speed photography reveals that two stages, the free flight of the particles' bulk over the plate and the adhes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09880
更新日期:2015-06-09 00:00:00
abstract::The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15794-8
更新日期:2017-11-14 00:00:00
abstract::The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02408
更新日期:2013-01-01 00:00:00
abstract::We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67516-2
更新日期:2020-06-29 00:00:00
abstract::Blockage of pores by particles is found in many processes, including filtration and oil extraction. We present filtration experiments through a linear array of ten channels with one dimension which is sub-micron, through which a dilute dispersion of Brownian polystyrene spheres flows under the action of a fixed pressu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30389-7
更新日期:2018-08-20 00:00:00