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Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.

Abstract：

:We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene - 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41-6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sokołowska A,Świerzko AS,Gajek G,Gołos A,Michalski M,Nowicki M,Szala-Poździej A,Wolska-Washer A,Brzezińska O,Wierzbowska A,Jamroziak K,Kowalski ML,Thiel S,Matsushita M,Jensenius JC,Cedzyński M

doi

10.1038/s41598-020-67516-2

subject

Has Abstract

pub_date

2020-06-29 00:00:00

pages

10561

issue

1

issn

2045-2322

pii

10.1038/s41598-020-67516-2

journal_volume

10

pub_type

杂志文章

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