Abstract:
:The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has greatly outpaced the development of new therapeutics, necessitating an alternative strategy for antibiotic development that considers the evolutionary mechanisms driving antibiotic resistance. In this study, we synthesize a novel inorganic antibiotic, phosphopyricin, which has antibiotic activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). We show that this potent antibiotic is bactericidal, and exhibits low toxicity in an acute dose assay in mice. As a synthetic compound that does not occur naturally, phosphopyricin would be evolutionarily foreign to microbes, thereby slowing the evolution of resistance. In addition, it loses antibiotic activity upon exposure to light, meaning that the active antibiotic will not accumulate in the general environment where strong selective pressures imposed by antibiotic residuals are known to accelerate resistance. Phosphopyricin represents an innovation in antimicrobials, having a synthetic core, and a photosensitive chemical architecture that would reduce accumulation in the environment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hubick S,Jayaraman A,McKeen A,Reid S,Alcorn J,Stavrinides J,Sterenberg BTdoi
10.1038/srep41999subject
Has Abstractpub_date
2017-02-06 00:00:00pages
41999issn
2045-2322pii
srep41999journal_volume
7pub_type
杂志文章abstract::A soil remediation method based on magnetic beneficiation is reported. A new magnetic solid chelator powder, FS@IDA (core-shell Fe3O4@SiO2 nanoparticles coated with iminodiacetic acid chelators), was used as a reactive magnetic carrier to selectively capture non-magnetic heavy metals in soil by chelation and removal b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21027
更新日期:2016-02-16 00:00:00
abstract::TiO2/graphene (TiO2-x/GR) composites, which are Ti(3+) self-doped TiO2 nanorods decorated on boron doped graphene sheets, were synthesized via a simple one-step hydrothermal method using low-cost NaBH4 as both a reducing agent and a boron dopant on graphene. The resulting TiO2 nanorods were about 200 nm in length with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05493
更新日期:2014-06-30 00:00:00
abstract::Cross-border equity and long-term debt securities portfolio investment networks are analysed from 2002 to 2012, covering the 2008 global financial crisis. They serve as network-proxies for measuring the robustness of the global financial system and the interdependence of financial markets, respectively. Two early-warn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03991
更新日期:2014-02-10 00:00:00
abstract::The Casimir force exerted on a gold dipolar nanoparticle by a finite-thickness slab of the natural hyperbolic material namely, the ortorhombic crystalline modification of boron nitride, is investigated. The main contribution to the force originates from the TM-polarized waves, for frequencies at which the parallel and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73995-0
更新日期:2020-10-08 00:00:00
abstract::Centrioles are essential for forming cilia, flagella and centrosomes. Successful centriole assembly requires proteins of the SAS-6 family, which can form oligomeric ring structures with ninefold symmetry in vitro. While important progress has been made in understanding SAS-6 protein biophysics, the mechanisms enabling...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27075
更新日期:2016-06-08 00:00:00
abstract::Diagnosing stable ischemic heart disease (IHD) is challenging, especially in females. Currently, no blood test is available. Plasma extracellular vesicles (EV) are emerging as potential biomarker source. We therefore aimed to identify stress induced ischemia due to stable IHD with plasma extracellular vesicle protein ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69297-0
更新日期:2020-07-23 00:00:00
abstract::The microwave emitting Radio Electric Asymmetric Conveyor (REAC) is a technology able to interact with biological tissues at low emission intensity (2 mW at the emitter and 2.4 or 5.8 GHz) by inducing radiofrequency generated microcurrents. It shows remarkable biological effects at many scales from gene modulations up...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18200
更新日期:2015-12-11 00:00:00
abstract::Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both substrate and edge states are known to have important effects. Here we show the 1/f noise for a microscopic graphene QD is substantially lar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08142
更新日期:2015-01-30 00:00:00
abstract::In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with Ath...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78828-8
更新日期:2020-12-14 00:00:00
abstract::Spintronic devices currently rely on magnetic switching or controlled motion of domain walls by an external magnetic field or spin-polarized current. Achieving the same degree of magnetic controllability using an electric field has potential advantages including enhanced functionality and low power consumption. Here w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00258
更新日期:2012-01-01 00:00:00
abstract::The macroscopically ordered structure of rod-like nanoapatites within the collagen matrix is of great significance for the mechanical performance of bones and teeth. However, the synthesis of macroscopically ordered nanoapatite remains a challenge. Inspired by the effect of citrate molecules on apatite crystals in nat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36843-w
更新日期:2019-01-24 00:00:00
abstract::Rapid eye movement (REM) sleep is considered to preferentially reprocess emotionally arousing memories. We tested this hypothesis by cueing emotional vs. neutral memories during REM and NREM sleep and wakefulness by presenting associated verbal memory cues after learning. Here we show that cueing during NREM sleep sig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39229
更新日期:2016-12-16 00:00:00
abstract::Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. Nevertheless, little is known about these viruses, including the mechanisms that control their production, which makes them one of the least un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21908
更新日期:2016-02-22 00:00:00
abstract::Mycoplasma mobile, a fish pathogen, exhibits its own specialized gliding motility on host cells based on ATP hydrolysis. The special protein machinery enabling this motility is composed of surface and internal protein complexes. Four proteins, MMOBs 1630, 1660, 1670, and 4860 constitute the internal complex, including...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60535-z
更新日期:2020-03-02 00:00:00
abstract::Early admission to the neurosciences intensive care unit (NSICU) is associated with improved patient outcomes. Natural language processing offers new possibilities for mining free text in electronic health record data. We sought to develop a machine learning model using both tabular and free text data to identify pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-80985-3
更新日期:2021-01-14 00:00:00
abstract::Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently, there is no treatment for this detrimental disorder. Development of therapies is largely hindered by lack of understanding of mechanisms involved i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50550-0
更新日期:2019-10-04 00:00:00
abstract::Finding overlapping communities of complex networks remains a challenge in network science. To address this challenge, one of the widely used approaches is finding the communities of links by optimizing the objective function, partition density. In this study, we show that partition density suffers from inverse resolu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12432-1
更新日期:2017-09-29 00:00:00
abstract::Our goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger's disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28-63 years; male, 91...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19690
更新日期:2016-01-21 00:00:00
abstract::Twenty-six imprinted genes were quantified in bovine in vivo produced oocytes and embryos using RNA-seq. Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17898
更新日期:2015-12-07 00:00:00
abstract::Diffraction gratings are an essential optical component of high-power, short-pulse lasers. The maximum output of high-power pulsed lasers is always determined by laser resistance of gratings and this resistance is strongly dependent on the local near electric field intensity in the grating structure. We presented a no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22479-3
更新日期:2018-03-27 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) plays a crucial role in breakdown of the blood-retinal barrier due to hyperpermeability in diabetic retinopathy (DR). However, the distinct signaling driven by VEGF and PlGF in the pathogenesis of DR remains unclear. In this study, we investi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51603-0
更新日期:2019-10-25 00:00:00
abstract::Despite their interest and threat status, the number of whales in world's oceans remains highly uncertain. Whales detection is normally carried out from costly sighting surveys, acoustic surveys or through high-resolution images. Since deep convolutional neural networks (CNNs) are achieving great performance in severa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50795-9
更新日期:2019-10-03 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24103-w
更新日期:2018-04-13 00:00:00
abstract::Channelopathy mutations prove informative on disease causing mechanisms and channel gating dynamics. We have identified a novel heterozygous mutation in the KCNA1 gene of a young proband displaying typical signs and symptoms of Episodic Ataxia type 1 (EA1). This mutation is in the S4 helix of the voltage-sensing domai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03041-z
更新日期:2017-07-04 00:00:00
abstract::Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50620-3
更新日期:2019-10-02 00:00:00
abstract::Aedes aegypti is the primary vector for transmission of Dengue, Zika and chikungunya viruses. Previously it was shown that Dengue virus infection of the mosquito led to an in increased expression of the odorant binding protein 22 (AeOBP22) within the mosquito salivary gland and that siRNA mediated knockdown of AeOBP22...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60242-9
更新日期:2020-02-24 00:00:00
abstract::Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42992
更新日期:2017-02-22 00:00:00
abstract::Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00745
更新日期:2012-01-01 00:00:00
abstract::The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle cells is an important criterion in using them as a cell source to ameliorate skeletal muscle impairments. However, differentiation of hESCs into skeletal muscle cells still remains a challenge, often requiring introduction of trans...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05916
更新日期:2014-08-01 00:00:00
abstract::Polyphenol oxidases (PPOs) are ubiquitously distributed among plants, bacteria, fungi and animals. They catalyze the hydroxylation of monophenols (monophenolase activity) and the oxidation of o-diphenols (diphenolase activity) to o-quinones. PPOs are commonly present as an isoenzyme family. In walnut (Juglans regia), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67415-6
更新日期:2020-07-02 00:00:00