Abstract:
:In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (T-SPARCLE) Registry, a multicenter, observational study of adult patients with ASCVD in Taiwan. Low HDL-C was defined as < 40 mg/dL for men and < 50 mg/dL for women. The primary outcome was a composite CV events including CV death, myocardial infarction (MI), stroke or cardiac arrest with resuscitation. A total of 3731 patients (mean age 65.6 years, 75.6% men) were included. Patients with on-treatment low HDL-C (44%, mean HDL-C 34.9 ± 6.8 mg/dL) were younger and with more diabetes and higher body weight. The mean follow-up time was 2.7 years. We used restricted cubic spline curves to examine the potential non-linear association between HDL-C and adverse outcomes. Decreased HDL-C levels were associated with a significantly increased risk of CV events in women (< 49 mg/dL in women) but not in men (< 42 mg/dL in men). However, the protective effect of elevated HDL-C levels was more prominent in men than in women. In ASCVD patients with statin therapy, low on-treatment HDL-C was common in Taiwan and associated with an increased risk of CV events in women. Higher HDL-C levels provided more protective effect in men than in women.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li YH,Tseng WK,Yin WH,Lin FJ,Wu YW,Hsieh IC,Lin TH,Sheu WH,Yeh HI,Chen JW,Wu CC,Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators.doi
10.1038/s41598-020-78828-8subject
Has Abstractpub_date
2020-12-14 00:00:00pages
21835issue
1issn
2045-2322pii
10.1038/s41598-020-78828-8journal_volume
10pub_type
杂志文章abstract::For many applications heterogeneity is a direct indicator of material quality. Reliable determination of chemical heterogeneity is however not a trivial task. Spectral imaging can be used for determining the spatial distribution of an analyte in a sample, thus transforming each pixel of an image into a sampling cell. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28889-7
更新日期:2018-07-11 00:00:00
abstract::Magic clusters have attracted significant interest to explore the dynamics of quantum dot (QD) nucleation and growth. At the same time, CdSe magic-sized QDs reveal broadband emission in the visible wavelength region, which advantageously offer simple integration of a single-type of nanomaterial and high color renderin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46581-2
更新日期:2019-07-11 00:00:00
abstract::Marine bacterial strains are of great interest for their ability to produce secondary metabolites with anticancer potentials. Isolation, identification, characterization and anticancer activities of isolated bacteria from El-Hamra Lake, Wadi El-Natrun (Egypt) were the objectives of this study. The isolated bacteria we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70945-8
更新日期:2020-08-21 00:00:00
abstract::Spreading broadly refers to the notion of an entity propagating throughout a networked system via its interacting components. Evidence of its ubiquity and severity can be seen in a range of phenomena, from disease epidemics to financial systemic risk. In order to understand the dynamics of these critical phenomena, co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22770-3
更新日期:2018-03-12 00:00:00
abstract::Two-dimensional (2D) gold nanoparticles can possess novel physical and chemical properties, which will greatly expand the utility of gold nanoparticles in a wide variety of applications ranging from catalysis to biomedicine. However, colloidal synthesis of such particles generally requires sophisticated synthetic tech...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06119
更新日期:2014-08-26 00:00:00
abstract::Carbon nanofibers were widely utilized to improve microwave absorption properties since they are a promising lightweight candidate. Adjustable conductive nanostructures of carbon nanofibers were synthesized by electrospinning technique. The conductive network is controlled by the polyvinyl pyrrolidone (PVP) content du...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38899-8
更新日期:2019-03-12 00:00:00
abstract::Immunoglobulin A nephropathy (IgAN) involves repeated events of gross haematuria with concurrent upper airway infections. The mucosal immune system, especially the tonsil, is considered the initial site of inflammation, although the role of the tonsillar microbiota has not been established in IgAN. In this study, we c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73035-x
更新日期:2020-10-01 00:00:00
abstract::Social context influences social decisions and outcome processing, partially depending on inter-individual differences. The present study investigated social context-dependent modulation of behavior and feedback processing in the ultimatum game (UG) in relation to inter-individual differences in social anxiety. Thirty...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep44062
更新日期:2017-03-09 00:00:00
abstract::Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12916
更新日期:2015-08-10 00:00:00
abstract::CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42081
更新日期:2017-02-03 00:00:00
abstract::Cholecystokinin (CCK) and leptin are satiety-controlling peptides, yet their interactive roles remain unclear. Here, we addressed this issue using in vitro and in vivo models. In rat C6 glioma cells, leptin pre-treatment enhanced Ca2+ mobilization by a CCK agonist (CCK-8s). This leptin action was reduced by Janus kina...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69035-6
更新日期:2020-07-20 00:00:00
abstract::Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilization of actin filament...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14216-z
更新日期:2017-10-20 00:00:00
abstract::The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics. Thymoquinone (TQ) is a naturally occurring compound with cumulative evidence of anti-cancer properties. In this study, we assessed the chemomodulatory potential of TQ to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30046-z
更新日期:2018-08-03 00:00:00
abstract::Music and language are complex hierarchical systems in which individual elements are systematically combined to form larger, syntactic structures. Suggestions that music and language share syntactic processing resources have relied on evidence that syntactic violations in music interfere with syntactic processing in l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36076-x
更新日期:2018-12-17 00:00:00
abstract::HIV-associated disseminated TB (tuberculosis) has been under-recognised and poorly characterised. Blood culture is the gold-standard diagnostic test, but is expensive, slow, and may under-diagnose TB dissemination. In a cohort of hospitalised HIV patients, we aimed to report the prevalence of TB-blood-culture positivi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09895-7
更新日期:2017-09-07 00:00:00
abstract::Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-25164-7
更新日期:2018-04-27 00:00:00
abstract::The physiologic response to tobacco smoke can be measured by gene-expression profiling of the airway epithelium. Temporal resolution of kinetics of gene-expression alterations upon smoking-cessation might delineate distinct biological processes that are activated during recovery from tobacco smoke exposure. Using whol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43295-3
更新日期:2019-05-06 00:00:00
abstract::Recombinant human erythropoietin (rHuEPO) is a biopharmaceutical drug given to patients who have a low hemoglobin related to chronic kidney disease, cancer or anemia. However, some patients repeatedly receiving rHuEPO develop anti-rHuEPO neutralizing antibodies leading to the development of pure red cell aplasia (PRCA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80402-1
更新日期:2021-01-15 00:00:00
abstract::The claim that organic agriculture produces higher levels of phytochemicals has been controversial for decades. Using strawberries as a model crop in field conditions, a preharvest leaf wounding stress was applied to study the production of phytochemicals in fruits. As a result phenolic compounds (PCs) and total solub...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55033-w
更新日期:2019-12-17 00:00:00
abstract::The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55938-6
更新日期:2019-12-20 00:00:00
abstract::Brain-computer interface (BCI) systems having the ability to classify brain waves with greater accuracy are highly desirable. To this end, a number of techniques have been proposed aiming to be able to classify brain waves with high accuracy. However, the ability to classify brain waves and its implementation in real-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45605-1
更新日期:2019-06-24 00:00:00
abstract::The discovery of the insertion of IbT-DNA1 and IbT-DNA2 into the cultivated (hexaploid) sweetpotato [Ipomoea batatas (L.) Lam.] genome constitutes a clear example of an ancient event of Horizontal Gene Transfer (HGT). However, it remains unknown whether the acquisition of both IbT-DNAs by the cultivated sweetpotato oc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48691-3
更新日期:2019-08-29 00:00:00
abstract:ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14708-y
更新日期:2017-10-27 00:00:00
abstract::There is significant interest in understanding the pathophysiology of Obsessive-Compulsive Disorder (OCD) using resting-state fMRI (rsfMRI). Previous studies acknowledge abnormalities within and beyond the fronto-striato-limbic circuit in OCD that require further clarifications. However, limited information could be i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80346-6
更新日期:2021-01-14 00:00:00
abstract::The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05532-5
更新日期:2017-07-14 00:00:00
abstract::The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the pres...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62195-5
更新日期:2020-03-30 00:00:00
abstract::The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20305-4
更新日期:2018-01-30 00:00:00
abstract::Thermoelectric properties of Graphene nano-ribbons (GNRs) with nanopores (NPs) are explored for a range of pore dimensions in order to achieve a high performance two-dimensional nano-scale thermoelectric device. We reduce thermal conductivity of GNRs by introducing pores in them in order to enhance their thermoelectri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11297
更新日期:2015-06-17 00:00:00
abstract::Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46166
更新日期:2017-04-11 00:00:00
abstract::Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16855-8
更新日期:2017-11-30 00:00:00