Abstract：
:Immunoglobulin A nephropathy (IgAN) involves repeated events of gross haematuria with concurrent upper airway infections. The mucosal immune system, especially the tonsil, is considered the initial site of inflammation, although the role of the tonsillar microbiota has not been established in IgAN. In this study, we compared the tonsillar microbiota of patients with IgAN (n = 21) and other glomerular diseases (n = 36) as well as, healthy controls (n = 23) from three medical centres in Korea. The microbiota was analysed from tonsil swabs using the Illumina MiSeq system based on 16S rRNA gene. Tonsillar bacterial diversity was higher in IgAN than in other glomerular diseases, although it did not differ from that of healthy controls. Principal coordinates analysis revealed differences between the tonsillar microbiota of IgAN and both healthy and disease controls. The proportions of Rahnella, Ruminococcus_g2, and Clostridium_g21 were significantly higher in patients with IgAN than in healthy controls (corrected p < 0.05). The relative abundances of several taxa were correlated with the estimated glomerular filtration rate, blood urea nitrogen, haemoglobin, and serum albumin levels. Based on our findings, tonsillar microbiota may be associated with clinical features and possible immunologic pathogenesis of IgAN.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Park JI,Kim TY,Oh B,Cho H,Kim JE,Yoo SH,Lee JP,Kim YS,Chun J,Kim BS,Lee Hdoi
10.1038/s41598-020-73035-xsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
16206issue
1issn
2045-2322pii
10.1038/s41598-020-73035-xjournal_volume
10pub_type
杂志文章abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13494
更新日期：2015-09-22 00:00:00
abstract：:We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending cor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35314-6
更新日期：2018-11-15 00:00:00
abstract：:It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24634-2
更新日期：2018-04-19 00:00:00
abstract：:Recombinant Mycobacterium strains such as recombinant BCG (rBCG) have received considerable attention for the HIV-1 vaccine development. Recently, we described a temperature-sensitive Mycobacterium paragordonae (Mpg) strain as a novel live tuberculosis vaccine that is safer and showed an enhanced protective effect aga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51875-6
更新日期：2019-10-29 00:00:00
abstract：:Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07750
更新日期：2015-01-13 00:00:00
abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77753-0
更新日期：2020-11-26 00:00:00
abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. METHODS:In a case-control study of CAH patients ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65897-y
更新日期：2020-06-01 00:00:00
abstract：:Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared vide...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19107
更新日期：2016-01-12 00:00:00
abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46333-2
更新日期：2019-07-15 00:00:00
abstract：:Recent reports on direct reprogramming of cancer cells (iPCs) which results in reduced tumorigenic potential has attributed the importance of epigenetics in tumorigenesis, but lacked genome-wide analysis. Here we describe successful generation of iPCs from non-small cell lung cancer (NSCLC) cell lines. Following repro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00592
更新日期：2012-01-01 00:00:00
abstract：:Under specific reaction conditions, levansucrase from Bacillus subtilis (SacB) catalyzes the synthesis of a low molecular weight levan through the non-processive elongation of a great number of intermediates. To deepen understanding of the polymer elongation mechanism, we conducted a meticulous examination of the fruc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32872-7
更新日期：2018-10-09 00:00:00
abstract：:The increasing performance of optical lattice clocks has made them attractive for scientific applications in space and thus has pushed the development of their components including the interrogation lasers of the clock transitions towards being suitable for space, which amongst others requires making them more power e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33973
更新日期：2016-09-26 00:00:00
abstract：:Cancer stem cells play an important role on tumor progression. Biomarkers of stem cell property and their relationship to extranodal involvement of malignant lymphocytes are undefined in diffuse large B-cell lymphoma (DLBCL). Here we showed that junctional adhesion molecule-A (JAM-A) was highly expressed in DLBCL pati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07964-5
更新日期：2017-08-07 00:00:00
abstract：:Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41362
更新日期：2017-01-27 00:00:00
abstract：:Nesfatin-1, a satiety molecule processed from nucleobindin2 (NUCB2), is implicated in visceral hypersensitivity in rats and colocalized with 5-hydroxytryptamine (5-HT) in the dorsal raphe nucleus (DRN). Maternal separation (MS) in rats contributes to visceral hypersensitivity via elevated expression of 5-HT in the DRN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27592-x
更新日期：2018-06-19 00:00:00
abstract：:Propionibacterium acnes (P. acnes) is a major skin-associated bacterium that was long considered commensal, until several studies revealed it to be an opportunistic pathogen. We investigated the ability of P. acnes surface proteins to recognize ECM proteins and showed that a 58 kDa P. acnes surface protein was specifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06940-3
更新日期：2017-07-25 00:00:00
abstract：:Magnetic skyrmions are topological quasiparticles of great interest for data storage applications because of their small size, high stability, and ease of manipulation via electric current. However, although models exist for some limiting cases, there is no universal theory capable of accurately describing the structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22242-8
更新日期：2018-03-13 00:00:00
abstract：:Bioerosion is a process with a high socio-economic impact that contributes to coastal retreat, and likely to increase with climate change. Whereas limestone bioerosion is well explained by a combination of mechanical and chemical pathways, the bioerosion mechanisms of silicates, which are harder and chemically more re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70265-x
更新日期：2020-08-07 00:00:00
abstract：:According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, and their long-term usability still needs to be fully investigat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11306-w
更新日期：2017-09-07 00:00:00
abstract：:This study aimed to detect the spatial distribution and high-risk clusters of female breast cancer mortality for the years 2011 to 2013 in Shandong Province, China. The urban-rural difference in the spatial distribution and clusters of disease mortality were also examined. Breast cancer mortality data were obtained fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00179-8
更新日期：2017-03-07 00:00:00
abstract：:Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature (before synaptogen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75047-z
更新日期：2020-10-22 00:00:00
abstract：:Although cooperation is central to the organisation of many social systems, relatively little is known about cooperation in situations of collective emergency. When groups of people flee from a danger such as a burning building or a terrorist attack, the collective benefit of cooperation is important, but the cost of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33417
更新日期：2016-09-15 00:00:00
abstract：:We investigate optical bound states in the continuum (BICs) supported by a photonic crystal (PhC) slab penetrated with periodic annular holes theoretically. Ultrahigh-quality factor (Q-factor) resonances associated with BICs are obtained with a Q-factor more than 108. The BICs can be seen at nonzero incident angles by...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29930-5
更新日期：2018-08-20 00:00:00
abstract：:Quantum physics is undoubtedly the most successful theory of the microscopic world, yet the complexities which arise in applying it even to simple atomic and molecular systems render the description of basic collision probabilities a formidable task. For this reason, approximations are often employed, the validity of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33425-8
更新日期：2018-10-10 00:00:00
abstract：:We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03589-w
更新日期：2017-06-12 00:00:00
abstract：:Viruses induce double-stranded RNA (dsRNA) in the host cells. The mammalian system has developed dsRNA-dependent recognition receptors such as RLRs that recognize the long stretches of dsRNA as PAMPs to activate interferon-mediated antiviral pathways and apoptosis in severe infection. Here we report an efficient antiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22550
更新日期：2016-03-03 00:00:00
abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26453
更新日期：2016-05-24 00:00:00
abstract：:Silver-based antibacterial agents have obtained wide attention due to the fact that bacteria in the environment is ubiquitous, which has become one of the most difficult problems for human health. However, the antibacterial mechanism and process are still inconclusive. Here, Ag2O nanoparticles (NPs) with uniform spher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81305-5
更新日期：2021-01-18 00:00:00
abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01432-w
更新日期：2017-05-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-53224-z
更新日期：2019-11-18 00:00:00
