Nesfatin-1 in the dorsal raphe nucleus influences visceral sensitivity via 5-HT neurons in male maternally separated rats.

abstract：:Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-β1-induced collagen production in cultured f...

journal_title：Scientific reports

authors： Tanaka KI,Niino T,Ishihara T,Takafuji A,Takayama T,Kanda Y,Sugizaki T,Tamura F,Kurotsu S,Kawahara M,Mizushima T

更新日期：2017-06-13 00:00:00

abstract：:Given our vast lignocellulosic biomass reserves and the difficulty in bioprocessing them without expensive pretreatment and fuel separation steps, the conversion of lignocellulosic biomass directly into electricity would be beneficial. Here we report the previously unexplored capabilities of thermophilic Geobacillus s...

journal_title：Scientific reports

authors： Shrestha N,Tripathi AK,Govil T,Sani RK,Urgun-Demirtas M,Kasthuri V,Gadhamshetty V

更新日期：2020-10-12 00:00:00

abstract：:Silver nanoparticles (AgNPs) demonstrating good antimicrobial activity are widely used in many fields. However, the impact of AgNPs on the community structures of marine biofilms that drive biogeochemical cycling processes and the recruitment of marine invertebrate larvae remains unknown. Here, we employed MiSeq seque...

journal_title：Scientific reports

authors： Yang JL,Li YF,Liang X,Guo XP,Ding DW,Zhang D,Zhou S,Bao WY,Bellou N,Dobretsov S

更新日期：2016-11-21 00:00:00

abstract：:Cell lytic enzymes represent an alternative to chemical decontamination or use of antibiotics to kill pathogenic bacteria, such as listeria. A number of phage cell lytic enzymes against listeria have been isolated and possess listericidal activity; however, there has been no attempt to incorporate these enzymes onto s...

journal_title：Scientific reports

authors： Solanki K,Grover N,Downs P,Paskaleva EE,Mehta KK,Lee L,Schadler LS,Kane RS,Dordick JS

更新日期：2013-01-01 00:00:00

abstract：:Quantum physics is undoubtedly the most successful theory of the microscopic world, yet the complexities which arise in applying it even to simple atomic and molecular systems render the description of basic collision probabilities a formidable task. For this reason, approximations are often employed, the validity of ...

journal_title：Scientific reports

authors： Laricchia G,Van Reeth P,Fayer SE,Brawley SJ,Kadokura R,Loreti A,Shipman M

更新日期：2018-10-10 00:00:00

abstract：:Brain tumors are fast proliferating and destructive within the brain microenvironment. Effective chemotherapeutic strategies are currently lacking which combat this deadly disease curatively. The glioma-specific chloride ion channel represents a specific target for therapy. Chlorotoxin (CTX), a peptide derived from sc...

journal_title：Scientific reports

authors： Xu T,Fan Z,Li W,Dietel B,Wu Y,Beckmann MW,Wrosch JK,Buchfelder M,Eyupoglu IY,Cao Z,Savaskan NE

更新日期：2016-02-02 00:00:00

abstract：:Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. However, searching for mutually ex...

journal_title：Scientific reports

authors： Pulido-Tamayo S,Weytjens B,De Maeyer D,Marchal K

更新日期：2016-11-03 00:00:00

abstract：:The multifactorial chronic inflammatory disease periodontitis, which is characterized by destruction of tooth-supporting tissues, has also been implicated as a risk factor for various systemic diseases. Although periodontitis has been studied extensively, neither disease-specific biomarkers nor therapeutic targets hav...

journal_title：Scientific reports

authors： Lundmark A,Davanian H,Båge T,Johannsen G,Koro C,Lundeberg J,Yucel-Lindberg T

更新日期：2015-12-21 00:00:00

abstract：:E-mail has become the main carrier of spreading malicious software and been widely used for phishing, even high-level persistent threats. The e-mail accounts with high social reputation are primary targets to be attacked and utilized by attackers, suffering a lot of probing attacks for a long time. In this paper, in o...

journal_title：Scientific reports

authors： Wen Y,Chen X,Zeng X,Wang W

更新日期：2020-04-29 00:00:00

abstract：:Climate change-induced extinctions are estimated to eliminate one in six known species by the end of the century. One major factor that will contribute to these extinctions is extreme climatic events. Here, we show the ecological impacts of recent record warm air temperatures and simultaneous peak drought conditions i...

journal_title：Scientific reports

authors： Bucciarelli GM,Clark MA,Delaney KS,Riley SPD,Shaffer HB,Fisher RN,Honeycutt RL,Kats LB

更新日期：2020-02-25 00:00:00

abstract：:This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an un...

journal_title：Scientific reports

authors： Sasaki M,Sanada Y,Katengeza EW,Yamamoto A

更新日期：2021-01-20 00:00:00

abstract：:Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

journal_title：Scientific reports

authors： Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

更新日期：2018-04-04 00:00:00

abstract：:Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of ...

journal_title：Scientific reports

authors： Hamilton PJ,Chen EY,Tolstikov V,Peña CJ,Picone JA,Shah P,Panagopoulos K,Strat AN,Walker DM,Lorsch ZS,Robinson HL,Mervosh NL,Kiraly DD,Sarangarajan R,Narain NR,Kiebish MA,Nestler EJ

更新日期：2020-10-22 00:00:00

abstract：:The natural course of intermittent exotropia and the factors affecting its control has been unclear. We aim to report the natural course of our cohort of 117 Chinese children with intermittent exotropia and to identify baseline parameters that may have predictive value in the control deterioration of the disease. The ...

journal_title：Scientific reports

authors： Kwok JJ,Chong GS,Ko ST,Yam JC

更新日期：2016-06-03 00:00:00

abstract：:A new, composite plasmonic waveguide based electromagnetic cloaking scheme is proposed with Si nano-spacer. Here we show, that the scattering fields of an object located on the cloak do not interact with the evanescent field, resulting in object's invisibility. Finite difference time domain (FDTD) numerical calculatio...

journal_title：Scientific reports

authors： Galutin Y,Falek E,Karabchevsky A

更新日期：2017-09-21 00:00:00

abstract：:The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not well defi...

journal_title：Scientific reports

authors： Dufour R,Daumar P,Mounetou E,Aubel C,Kwiatkowski F,Abrial C,Vatoux C,Penault-Llorca F,Bamdad M

更新日期：2015-08-03 00:00:00

abstract：:In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors sugges...

journal_title：Scientific reports

authors： Weng L,Hu X,Kumar B,Garcia M,Todorov I,Jung X,Marcucci G,Forman SJ,Chen CC

更新日期：2016-12-08 00:00:00

abstract：:Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fib...

journal_title：Scientific reports

authors： Coughlan CA,Chou LD,Jing JC,Chen JJ,Rangarajan S,Chang TH,Sharma GK,Cho K,Lee D,Goddard JA,Chen Z,Wong BJ

更新日期：2016-03-10 00:00:00

abstract：:Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...

journal_title：Scientific reports

authors： Ribeiro LNM,Franz-Montan M,Alcântara ACS,Breitkreitz MC,Castro SR,Guilherme VA,Muniz BV,Rodrigues da Silva GH,de Paula E

更新日期：2020-07-09 00:00:00

abstract：:Near-surface ozone is enhanced under particular chemical reactions and physical processes. This study showed the seasonal variation of near-surface ozone in Nicosia, Cyprus and focused in summers when the highest ozone levels were noted using a seven year hourly dataset from 2007 to 2014. The originality of this study...

journal_title：Scientific reports

authors： Pyrgou A,Hadjinicolaou P,Santamouris M

更新日期：2018-06-15 00:00:00

abstract：:Balancing the upper body is pivotal for upright and efficient gait. While models have identified potentially useful characteristics of biarticular thigh muscles for postural control of the upper body, experimental evidence for their specific role is lacking. Based on theoretical findings, we hypothesised that biarticu...

journal_title：Scientific reports

authors： Schumacher C,Berry A,Lemus D,Rode C,Seyfarth A,Vallery H

更新日期：2019-10-10 00:00:00

abstract：:When exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative processes. The development of robust strains therefore represents a pivotal challenge for the implementation of cost-effective bioprocesses. Altering ...

journal_title：Scientific reports

authors： Martani F,Marano F,Bertacchi S,Porro D,Branduardi P

更新日期：2015-12-14 00:00:00

abstract：:Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In ...

journal_title：Scientific reports

authors： Kasubuchi M,Watanabe K,Hirano K,Inoue D,Li X,Terasawa K,Konishi M,Itoh N,Kimura I

更新日期：2017-07-12 00:00:00

abstract：:In recent years, conservation biologists have raised awareness about the risk of ecological interference between massively introduced managed honeybees and the native wild bee fauna in protected natural areas. In this study, we surveyed wild bees and quantified their nectar and pollen foraging success in a rosemary Me...

journal_title：Scientific reports

authors： Henry M,Rodet G

更新日期：2018-06-18 00:00:00

abstract：:The honey bee is threatened by biological agents and pesticides that can act in combination to induce synergistic effects on its physiology and lifespan. The synergistic effects of a parasite/pesticide combination have been demonstrated on workers and queens, but no studies have been performed on drones despite their ...

journal_title：Scientific reports

authors： Kairo G,Biron DG,Ben Abdelkader F,Bonnet M,Tchamitchian S,Cousin M,Dussaubat C,Benoit B,Kretzschmar A,Belzunces LP,Brunet JL

更新日期：2017-08-17 00:00:00

abstract：:Interfacial charge transfer from photoexcited ruthenium-based N3 dye molecules into ZnO thin films received controversial interpretations. To identify the physical origin for the delayed electron transfer in ZnO compared to TiO2, we probe directly the electronic structure at both dye-semiconductor interfaces by applyi...

journal_title：Scientific reports

authors： Borgwardt M,Wilke M,Kampen T,Mähl S,Xiao M,Spiccia L,Lange KM,Kiyan IY,Aziz EF

更新日期：2016-04-13 00:00:00

abstract：:The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along 〈111〉. Through analys...

journal_title：Scientific reports

authors： Zhou WH,Zhang CG,Li YG,Zeng Z

更新日期：2014-05-28 00:00:00

abstract：:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs...

journal_title：Scientific reports

authors： Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté J

更新日期：2017-07-11 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted...

journal_title：Scientific reports

authors： Jiang X,Zhang B,Zhao J,Xu Y,Han H,Su K,Tao J,Fan R,Zhao X,Li L,Li MD

更新日期：2019-09-17 00:00:00

abstract：:Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...

journal_title：Scientific reports

authors： Chang ZL,Li BX,Liu B,Yao L,Yu J,Jiang GM,Tan JH

更新日期：2019-03-01 00:00:00