Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential.

abstract：:Mixed strain infections of Mycobacterium tuberculosis make diagnosis, treatment, and control of tuberculosis (TB) more difficult. This study was aimed to evaluate the relationship between mixed infections, antibiotic resistance patterns and treatment of TB patients. In this study, among 2850 suspected TB clinical samp...

journal_title：Scientific reports

authors： Kargarpour Kamakoli M,Sadegh HR,Farmanfarmaei G,Masoumi M,Fateh A,Javadi G,Rahimi Jamnani F,Vaziri F,Siadat SD

更新日期：2017-01-25 00:00:00

abstract：:In this work, an enzymatic biofuel cell (EBC) based on a membraneless and mediatorless glucose enzymatic fuel cell system was constructed for operation in physiological conditions (pH 7.0 and temperature 37 °C). The new platform EBC made of nanocomposite, including magnetic nanoparticles (Fe3O4 NPs) and reduced graphe...

journal_title：Scientific reports

authors： Pakapongpan S,Tuantranont A,Poo-Arporn RP

更新日期：2017-10-10 00:00:00

abstract：:We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteiniz...

journal_title：Scientific reports

authors： Chen C,Wang N,Zhai H,Nie X,Sun H,Han B,Li Q,Chen Y,Cheng J,Xia F,Zhao L,Zheng Y,Shen Z,Lu Y

更新日期：2016-11-29 00:00:00

abstract：:Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N(9)-(2...

journal_title：Scientific reports

authors： Wang J,Bonnesen PV,Rangel E,Vallejo E,Sanchez-Castillo A,James Cleaves Ii H,Baddorf AP,Sumpter BG,Pan M,Maksymovych P,Fuentes-Cabrera M

更新日期：2016-01-04 00:00:00

abstract：:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...

journal_title：Scientific reports

authors： Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

更新日期：2016-04-07 00:00:00

abstract：:Myelopoiesis involves differentiation of hematopoietic stem cells to cellular populations that are restricted in their self-renewal capacity, beginning with the common myeloid progenitor (CMP) and leading to mature cells including monocytes and granulocytes. This complex process is regulated by various extracellular a...

journal_title：Scientific reports

authors： Rajasekhar M,Schmitz U,Flamant S,Wong JJ,Bailey CG,Ritchie W,Holst J,Rasko JEJ

更新日期：2018-05-08 00:00:00

abstract：:The Fabry-Pérot interferometer is used in a variety of high-precision optical interferometry applications, such as gravitational wave detection. It is also used in various types of laser resonators to act as a narrow band filter. In addition, ultra-compact Fabry-Pérot interferometers are used in the optical resonators...

journal_title：Scientific reports

authors： Tsujiie Y,Kawamura Y

更新日期：2018-10-12 00:00:00

abstract：:15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the stru...

journal_title：Scientific reports

authors： Kim SN,Akindehin S,Kwon HJ,Son YH,Saha A,Jung YS,Seong JK,Lim KM,Sung JH,Maddipati KR,Lee YH

更新日期：2018-06-11 00:00:00

abstract：:Honey bees are under pressure due to abnormal high colony death rates, especially during the winter. The infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally considered as the bees' most important biological threats. Almost all efforts to remedy this dual infection h...

journal_title：Scientific reports

authors： de Graaf DC,Laget D,De Smet L,Claeys Boúúaert D,Brunain M,Veerkamp RF,Brascamp EW

更新日期：2020-08-31 00:00:00

abstract：:Cellular membrane distortion invokes variations in cellular physiology. However, lack of an appropriate system to control the stress and facilitate molecular analyses has hampered progress of relevant studies. In this study, a microfluidic system that finely manipulates membrane distortion of Chlamydomonas reinhardtii...

journal_title：Scientific reports

authors： Min SK,Yoon GH,Joo JH,Sim SJ,Shin HS

更新日期：2014-04-14 00:00:00

abstract：:Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-fold selectivity of...

journal_title：Scientific reports

authors： Kachel HS,Patel RN,Franzyk H,Mellor IR

更新日期：2016-11-30 00:00:00

abstract：:Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage dysplasia, but the ...

journal_title：Scientific reports

authors： Wang C,Xu CX,Alippe Y,Qu C,Xiao J,Schipani E,Civitelli R,Abu-Amer Y,Mbalaviele G

更新日期：2017-07-07 00:00:00

abstract：:The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wa...

journal_title：Scientific reports

authors： Long CY,Lin KL,Shen CR,Ker CR,Liu YY,Loo ZX,Hsiao HH,Lee YC

更新日期：2021-01-15 00:00:00

abstract：:This paper analyzed the compositional and structural changes of humic acid (HA) after combined with phosphate fertilizer (PHA), and investigated its effects on the growth of maize seedlings with four humic acid concentrations. The results showed that the atomic ratios of O/C and (O + N)/N of PHA were significantly low...

journal_title：Scientific reports

authors： Jing J,Zhang S,Yuan L,Li Y,Lin Z,Xiong Q,Zhao B

更新日期：2020-10-15 00:00:00

abstract：:Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...

journal_title：Scientific reports

authors： Do NH,Pham HH,Le TM,Lauwaert J,Diels L,Verberckmoes A,Do NHN,Tran VT,Le PK

更新日期：2020-12-04 00:00:00

abstract：:We investigated if fermentation with probiotic cultures could improve the production of health-promoting biological compounds in Astragalus membranaceus. We tested the probiotics Enterococcus faecium, Lactobacillus plantarum and Enterococcus faecium + Lactobacillus plantarum and applied PacBio single molecule, real-ti...

journal_title：Scientific reports

authors： Qiao H,Zhang X,Shi H,Song Y,Bian C,Guo A

更新日期：2018-08-08 00:00:00

abstract：:Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using ...

journal_title：Scientific reports

authors： Pfaender S,Sauer AK,Hagmeyer S,Mangus K,Linta L,Liebau S,Bockmann J,Huguet G,Bourgeron T,Boeckers TM,Grabrucker AM

更新日期：2017-03-27 00:00:00

abstract：:The strategy of using redox additive electrolyte in combination with multiwall carbon nanotubes/metal oxide composites leads to a substantial improvements in the specific energy and power of asymmetric supercapacitors (ASCs). When the pure electrolyte is optimally modified with a redox additive viz., KI, ~105% increas...

journal_title：Scientific reports

authors： Singh A,Chandra A

更新日期：2016-05-17 00:00:00

abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...

journal_title：Scientific reports

authors： Patra C,Kontarakis Z,Kaur H,Rayrikar A,Mukherjee D,Stainier DYR

更新日期：2017-06-02 00:00:00

abstract：:Arabidopsis thaliana contains the putative K+ efflux transporters KEA1-KEA6, similar to KefB and KefC of Escherichia coli. KEA1-KEA3 are involved in the regulation of photosynthetic electron transport and chloroplast development. KEA4-KEA6 mediate pH regulation of the endomembrane network during salinity stress. Howev...

journal_title：Scientific reports

authors： Tsujii M,Kera K,Hamamoto S,Kuromori T,Shikanai T,Uozumi N

更新日期：2019-07-11 00:00:00

abstract：:Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the risk of developing cardiovascular diseases (CVD). Previous studies that compared FRS and MS have focused on high-income urban areas. This study focused on the comparison between FRS and MS when used in nomadic minorities in mountain...

journal_title：Scientific reports

authors： Yang W,Ma R,Zhang X,Guo H,He J,Mao L,Mu L,Hu Y,Yan Y,Liu J,Ma J,Li S,Ding Y,Zhang M,Zhang J,Guo S

更新日期：2018-11-07 00:00:00

abstract：:There is no preclinical mouse model to investigate pulmonary Mycobacteroides abscessus (formerly Mycobacterium abscessus) infection in an immunocompetent mouse strain, especially in the context of antibiotic testing and regimen development. We developed a mouse model of pulmonary M. abscessus infection using the aeros...

journal_title：Scientific reports

authors： Maggioncalda EC,Story-Roller E,Mylius J,Illei P,Basaraba RJ,Lamichhane G

更新日期：2020-02-28 00:00:00

abstract：:West Nile virus (WNV) is a neurotropic pathogen which causes zoonotic disease in humans. Recently, there have been an increasing number of infected cases and there are no clinically approved vaccines or effective drugs to treat WNV infections in humans. The purpose of this study was to facilitate vaccine and antiviral...

journal_title：Scientific reports

authors： Li W,Ma L,Guo LP,Wang XL,Zhang JW,Bu ZG,Hua RH

更新日期：2017-06-12 00:00:00

abstract：:Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and a...

journal_title：Scientific reports

authors： Scoville EA,Allaman MM,Adams DW,Motley AK,Peyton SC,Ferguson SL,Horst SN,Williams CS,Beaulieu DB,Schwartz DA,Wilson KT,Coburn LA

更新日期：2019-02-27 00:00:00

abstract：:Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatmen...

journal_title：Scientific reports

authors： Rajendran RL,Gangadaran P,Bak SS,Oh JM,Kalimuthu S,Lee HW,Baek SH,Zhu L,Sung YK,Jeong SY,Lee SW,Lee J,Ahn BC

更新日期：2017-11-14 00:00:00

abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

journal_title：Scientific reports

authors： Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

更新日期：2019-10-16 00:00:00

abstract：:This work introduces a new population-based stochastic search technique, named multi-variant differential evolution (MVDE) algorithm for solving fifteen well-known real world problems from UCI repository and compared to four popular optimization methods. The MVDE proposes a new self-adaptive scaling factor based on co...

journal_title：Scientific reports

authors： Hassan S,Hemeida AM,Alkhalaf S,Mohamed AA,Senjyu T

更新日期：2020-10-14 00:00:00

abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

journal_title：Scientific reports

authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

更新日期：2012-01-01 00:00:00

abstract：:Organic gases undergoing conversion to form secondary organic aerosol (SOA) during atmospheric aging are largely unidentified, particularly in regions influenced by anthropogenic emissions. SOA dominates the atmospheric organic aerosol burden and this knowledge gap contributes to uncertainties in aerosol effects on cl...

journal_title：Scientific reports

authors： Bruns EA,El Haddad I,Slowik JG,Kilic D,Klein F,Baltensperger U,Prévôt AS

更新日期：2016-06-17 00:00:00

abstract：:Ants are a dominant insect group in terrestrial ecosystems and many myrmecophilous species evolve to associate with ants to gain benefits. One iconic example is myrmecophilous butterflies that often produce ant-mimicking vibrational calls to modulate ant behaviors. Despite its popularity, empirical exploration of how ...

journal_title：Scientific reports

authors： Lin YH,Liao YC,Yang CS,Billen J,Yang MM,Hsu YF

更新日期：2019-12-06 00:00:00