Abstract：
:Cell lytic enzymes represent an alternative to chemical decontamination or use of antibiotics to kill pathogenic bacteria, such as listeria. A number of phage cell lytic enzymes against listeria have been isolated and possess listericidal activity; however, there has been no attempt to incorporate these enzymes onto surfaces. We report three facile routes for the surface incorporation of the listeria bacteriophage endolysin Ply500: covalent attachment onto FDA approved silica nanoparticles (SNPs), incorporation of SNP-Ply500 conjugates into a thin poly(hydroxyethyl methacrylate) film; and affinity binding to edible crosslinked starch nanoparticles via construction of a maltose binding protein fusion. These Ply500 formulations were effective in killing L. innocua (a reduced pathogenic surrogate) at challenges up to 10(5) CFU/ml both in non-growth sustaining PBS as well as under growth conditions on lettuce. This strategy represents a new route toward achieving highly selective and efficient pathogen decontamination and prevention in public infrastructure.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Solanki K,Grover N,Downs P,Paskaleva EE,Mehta KK,Lee L,Schadler LS,Kane RS,Dordick JSdoi
10.1038/srep01584subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1584issn
2045-2322pii
srep01584journal_volume
3pub_type
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