Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities.

abstract：:SLC10A7 represents an orphan member of the Solute Carrier Family SLC10. Recently, mutations in the human SLC10A7 gene were associated with skeletal dysplasia, amelogenesis imperfecta, and decreased bone mineral density. However, the exact molecular function of SLC10A7 and the mechanisms underlying these pathologies ar...

journal_title：Scientific reports

authors： Karakus E,Wannowius M,Müller SF,Leiting S,Leidolf R,Noppes S,Oswald S,Diener M,Geyer J

更新日期：2020-04-29 00:00:00

abstract：:Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive f...

journal_title：Scientific reports

authors： Zhang B,Han M,Tan S,De Yang F,Tan Y,Jiang S,Zhang X,Huang XF

更新日期：2017-09-19 00:00:00

abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...

journal_title：Scientific reports

authors： Bhowal A,Majumder S,Ghosh S,Basu S,Sen D,Roychowdhury S,Sengupta S,Chatterji U

更新日期：2017-08-29 00:00:00

abstract：:It has been reported that non-selective autophagy of infected hepatocytes could facilitate the development of malaria in the liver stage, but the fate of parasites following selective autophagy of infected hepatocytes is still not very clear. Here, we confirmed that sporozoite infection can induce a selective autophag...

journal_title：Scientific reports

authors： Zhao C,Liu T,Zhou T,Fu Y,Zheng H,Ding Y,Zhang K,Xu W

更新日期：2016-11-30 00:00:00

abstract：:The aim of this study was to compare the effects of an aerobic training program with a strength training program on body composition and energy expenditure in overweight or obese (29.06 ± 3.49 kg/m2) young adults (21.96 ± 1.90 years). Subjects (N = 109) were randomly assigned to one of three groups: a control group (C...

journal_title：Scientific reports

authors： Fernández-García JC,Gálvez-Fernández I,Mercadé-Melé P,Gavala-González J

更新日期：2020-03-24 00:00:00

abstract：:In this paper, we demonstrate a novel dual-pump approach to generate robust optical frequency comb with varying free spectral range (FSR) spacing in a CMOS-compatible high-Q micro-ring resonator (MRR). The frequency spacing of the comb can be tuned by an integer number FSR of the MRR freely in our dual-pump scheme. Th...

journal_title：Scientific reports

authors： Wang W,Chu ST,Little BE,Pasquazi A,Wang Y,Wang L,Zhang W,Wang L,Hu X,Wang G,Hu H,Su Y,Li F,Liu Y,Zhao W

更新日期：2016-06-24 00:00:00

abstract：:The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) pa...

journal_title：Scientific reports

authors： Eligini S,Cosentino N,Fiorelli S,Fabbiocchi F,Niccoli G,Refaat H,Camera M,Calligaris G,De Martini S,Bonomi A,Veglia F,Fracassi F,Crea F,Marenzi G,Tremoli E

更新日期：2019-06-18 00:00:00

abstract：:Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could le...

journal_title：Scientific reports

authors： Gonzalez-Escamilla G,Chirumamilla VC,Meyer B,Bonertz T,von Grotthus S,Vogt J,Stroh A,Horstmann JP,Tüscher O,Kalisch R,Muthuraman M,Groppa S

更新日期：2018-09-28 00:00:00

abstract：:Numerous past studies have investigated neurophysiological correlates of music-syntactic processing. However, only little is known about how prior knowledge about an upcoming syntactically irregular event modulates brain correlates of music-syntactic processing. Two versions of a short chord sequence were presented re...

journal_title：Scientific reports

authors： Guo S,Koelsch S

更新日期：2016-01-19 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L...

journal_title：Scientific reports

authors： Witwinowski J,Moutiez M,Coupet M,Correia I,Belin P,Ruzzini A,Saulnier C,Caraty L,Favry E,Seguin J,Lautru S,Lequin O,Gondry M,Pernodet JL,Darbon E

更新日期：2019-12-27 00:00:00

abstract：:The usage of gelatin hydrogel is limited due to its instability and poor mechanical properties, especially under physiological conditions. Divalent metal ions present in gelatin such as Ca(2+) and Fe(2+) play important roles in the gelatin molecule interactions. The objective of this study was to determine the impact ...

journal_title：Scientific reports

authors： Xing Q,Yates K,Vogt C,Qian Z,Frost MC,Zhao F

更新日期：2014-04-16 00:00:00

abstract：:Nash equilibrium is widely present in various social disputes. As of now, in structured static populations, such as social networks, regular, and random graphs, the discussions on Nash equilibrium are quite limited. In a relatively stable static gaming network, a rational individual has to comprehensively consider all...

journal_title：Scientific reports

authors： Zhang Y,Aziz-Alaoui MA,Bertelle C,Guan J

更新日期：2014-08-29 00:00:00

abstract：:Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general ...

journal_title：Scientific reports

authors： Coutinho C,Bastos LS,da Mota JC,Toledo L,Costa K,Bertoni N,Bastos FI

更新日期：2019-01-24 00:00:00

abstract：:Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be indu...

journal_title：Scientific reports

authors： Mandel Y,Manivanh R,Dalal R,Huie P,Wang J,Brinton M,Palanker D

更新日期：2013-01-01 00:00:00

abstract：:We tried to establish a reliable detrusor underactivity (DUA) rat model and to investigate pathophysiology of chronic bladder ischemia (CBI) on voiding behavior and bladder function. Adult male rats were divided into five groups. The arterial injury (AI) groups (AI-10, AI-20, AI-30) underwent vascular endothelial dama...

journal_title：Scientific reports

authors： Kim M,Yu HY,Ju H,Shin JH,Kim A,Lee J,Ryu CM,Yun H,Lee S,Lim J,Heo J,Shin DM,Choo MS

更新日期：2019-11-08 00:00:00

abstract：:The number of patients with dry eye disease (DED) is increasing, and DED has become an urgent public health problem. A comorbidity of mental disorders has been reported in DED patients. We hypothesized that physical and psychological stressors impair tear secretion. To examine the relationship between stress loading a...

journal_title：Scientific reports

authors： Sano K,Kawashima M,Imada T,Suzuki T,Nakamura S,Mimura M,Tanaka KF,Tsubota K

更新日期：2019-03-04 00:00:00

abstract：:There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour characteristics using previously validated methods. Our results suggest a ...

journal_title：Scientific reports

authors： Bowen J,Fatjó J,Serpell JA,Bulbena-Cabré A,Leighton E,Bulbena A

更新日期：2019-06-13 00:00:00

abstract：:We report the temperature dependence of the dielectric function ε = ε1 + iε2 and critical point (CP) energies of biaxial α-SnS in the spectral energy region from 0.74 to 6.42 eV and temperatures from 27 to 350 K using spectroscopic ellipsometry. Bulk SnS was grown by temperature gradient method. Dielectric response fu...

journal_title：Scientific reports

authors： Nguyen HT,Le VL,Nguyen TMH,Kim TJ,Nguyen XA,Kim B,Kim K,Lee W,Cho S,Kim YD

更新日期：2020-10-27 00:00:00

abstract：:The subjective experience of thermal pain follows the detection and encoding of noxious stimuli by primary afferent neurons called nociceptors. However, nociceptor morphology has been hard to access and the mechanisms of signal transduction remain unresolved. In order to understand how heat transducers in nociceptors ...

journal_title：Scientific reports

authors： Dezhdar T,Moshourab RA,Fründ I,Lewin GR,Schmuker M

更新日期：2015-12-07 00:00:00

abstract：:There are at least two different principles of how ADP-ribose (ADPR) induces activation of TRPM2 channels. In human TRPM2, gating requires the C-terminal NUDT9H domain as ADPR-binding module, whereas in sea anemone, NUDT9H is dispensable and binding of ADPR occurs N-terminally. Zebrafish TRPM2 needs both, the N-termin...

journal_title：Scientific reports

authors： Kühn FJP,Ehrlich W,Barth D,Kühn C,Lückhoff A

更新日期：2019-12-16 00:00:00

abstract：:Knowledge about a tool's dynamics can be acquired from the visual configuration of the tool and through physical interaction. Here, we examine how visual information affects the generalization of dynamic learning during tool use. Subjects rotated a virtual hammer-like object while we varied the object dynamics separat...

journal_title：Scientific reports

authors： Sadeghi M,Sheahan HR,Ingram JN,Wolpert DM

更新日期：2019-02-25 00:00:00

abstract：:Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate...

journal_title：Scientific reports

authors： Feng J,Wu J,Zhu R,Feng D,Yu L,Zhang Y,Bu D,Li C,Zhou Y,Si L,Liu Y,Liang Z,Xu J,Wu T

更新日期：2017-03-09 00:00:00

abstract：:The distribution of carbon from a branch setting pod in alfalfa was investigated during the seed development of seeds to determine the relative contribution of pod and leaf photoassimilates to the total C balance and to investigate the partitioning of these photoassimilates to other plant organs. A 13Clabeling procedu...

journal_title：Scientific reports

authors： Zhang W,Mao P,Li Y,Wang M,Xia F,Wang H

更新日期：2017-02-07 00:00:00

abstract：:Surface enhanced Raman scattering (SERS) spectroscopy becomes increasingly used in biosensors for its capacity to detect and identify single molecules. In practice, a large number of SERS spectra are acquired and reliable ranking methods are thus essential for analysing all these data. Supervised classification strate...

journal_title：Scientific reports

authors： Leray A,Brulé T,Buret M,Colas des Francs G,Bouhelier A,Dereux A,Finot E

更新日期：2016-02-02 00:00:00

abstract：:Today's electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmen...

journal_title：Scientific reports

authors： Yong J,Hassan B,Liang Y,Ganesan K,Rajasekharan R,Evans R,Egan G,Kavehei O,Li J,Chana G,Nasr B,Skafidas E

更新日期：2017-11-07 00:00:00

abstract：:Endothelin-1 (ET-1) is associated with endothelial dysfunction and vasoconstriction. Increased circulating ET-1 levels are associated with long-term cardiovascular mortality. Renalase, released from kidney, metabolizes catecholamines and regulates blood pressure. An increase in circulating renalase levels has been rep...

journal_title：Scientific reports

authors： Li YH,Sheu WH,Lee WJ,Wang J-,Fu CP,Liang KW,Lee IT

更新日期：2018-05-09 00:00:00

abstract：:Dynamical polarization of nuclear spin ensembles is of central importance for magnetic resonance studies, precision sensing and for applications in quantum information theory. Here we propose a scheme to generate long-lived singlet pairs in an unpolarized nuclear spin ensemble which is dipolar coupled to the electron ...

journal_title：Scientific reports

authors： Greiner JN,Dasari DBR,Wrachtrup J

更新日期：2017-04-03 00:00:00

abstract：:Coral reefs around the world are undergoing severe decline in the past few decades. Mass coral mortalities have predominantly been reported to be caused by coral bleaching or disease outbreaks. Temporary hypoxic conditions caused by algal blooms can trigger mass coral mortalities though are reported rarely. In this st...

journal_title：Scientific reports

authors： Raj KD,Mathews G,Obura DO,Laju RL,Bharath MS,Kumar PD,Arasamuthu A,Kumar TKA,Edward JKP

更新日期：2020-12-17 00:00:00

abstract：:Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates, including disease-associated deposits. The BRICHOS domain from familial dementia associated protein Bri2 (or ITM2B) probably chaperones its specific proprotein region with high β-sheet propensity ...

journal_title：Scientific reports

authors： Poska H,Leppert A,Tigro H,Zhong X,Kaldmäe M,Nilsson HE,Hebert H,Chen G,Johansson J

更新日期：2020-06-17 00:00:00