Abstract：
:Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric current to induce rapid constriction in femoral and mesenteric arteries and veins in rats. Electrically-induced vasoconstriction could be induced in seconds while blood vessels dilated back to their original size within minutes after stimulation. At higher settings, a blood clotting formed, leading to complete and permanent occlusion of the vessels. The latter regime dramatically decreased the bleeding rate in the injured femoral and mesenteric arteries, with a complete hemorrhage arrest achieved within seconds. The average blood loss from the treated femoral artery during the first minute after injury was about 7 times less than that of a non-treated control. This new treatment modality offers a promising approach to non-damaging control of bleeding during surgery, and to efficient hemorrhage arrest in trauma patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mandel Y,Manivanh R,Dalal R,Huie P,Wang J,Brinton M,Palanker Ddoi
10.1038/srep02111subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2111issn
2045-2322pii
srep02111journal_volume
3pub_type
杂志文章abstract：:Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10492-x
更新日期：2017-09-06 00:00:00
abstract：:We investigate the behaviour of the recently proposed Quantum PageRank algorithm, in large complex networks. We find that the algorithm is able to univocally reveal the underlying topology of the network and to identify and order the most relevant nodes. Furthermore, it is capable to clearly highlight the structure of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02773
更新日期：2013-10-04 00:00:00
abstract：:The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10465-0
更新日期：2017-08-31 00:00:00
abstract：:We have applied a combined computational procedure based on inverse and direct docking in order to identify putative protein targets of a panel of mycotoxins and xenobiotic compounds that can contaminate food and that are known to have several detrimental effects on human health. This procedure allowed us to identify ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15148-4
更新日期：2017-11-09 00:00:00
abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13494
更新日期：2015-09-22 00:00:00
abstract：:Cancer dissemination is initiated by the movement of cells into the vasculature which has been reported to be triggered by EMT (epithelial to mesenchymal transition). Cellular dissemination also requires proteases that remodel the extracellular matrix. The protease, plasmin is a prominent player in matrix remodeling a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32433-y
更新日期：2018-09-20 00:00:00
abstract：:Cortical spreading depolarization (SD) involves activation of NMDA receptors and elicit neurovascular unit dysfunction. NMDA cannot trigger SD in newborns, thus its effect on neurovascular function is not confounded by other aspects of SD. The present study investigated if NMDA affected hypercapnia-induced microvascul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55468-1
更新日期：2019-12-11 00:00:00
abstract：:Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. PubMed, Embase.com and Cochrane Library databases were searched up to 31 October 2015 and randomized controlled trials (RCTs), cohort studies or...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep33743
更新日期：2016-09-19 00:00:00
abstract：:Ovarian cancer (OC) is the most lethal gynecological carcinoma due to the lack of diagnostic markers and effective drug targets. Discovery of new therapeutic targets in OC to improve the treatment outcome is urgently needed. We performed proteomic analysis of OC specimens and the paired normal tissues and revealed tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48992-7
更新日期：2019-09-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29525-0
更新日期：2018-07-25 00:00:00
abstract：:Because of their exceptional local-field enhancement and ultrasmall mode volume, plasmonic components can integrate photonics and electronics at nanoscale, and active control of plasmons is the key. However, all-optical modulation of plasmonic response with nanometer mode volume and unity modulation depth is still lac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24293
更新日期：2016-04-11 00:00:00
abstract：:Mitochondria are key cellular signaling platforms, affecting fundamental processes such as cell proliferation, differentiation and death. However, it remains unclear how mitochondrial signaling affects other organelles, particularly lysosomes. Here, we demonstrate that mitochondrial respiratory chain (RC) impairments ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45076
更新日期：2017-03-27 00:00:00
abstract：:The mammalian central nervous system (CNS) contains various types of neurons with different neuronal functions. In contrast to established roles of cell type-specific transcription factors on neuronal specification and maintenance, whether ubiquitous transcription factors have conserved or differential neuronal functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34575
更新日期：2016-09-30 00:00:00
abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23173
更新日期：2016-03-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18707-x
更新日期：2018-01-15 00:00:00
abstract：:Networks are a powerful abstraction with applicability to a variety of scientific fields. Models explaining their morphology and growth processes permit a wide range of phenomena to be more systematically analysed and understood. At the same time, creating such models is often challenging and requires insights that ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06284
更新日期：2014-09-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33187
更新日期：2016-09-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28225
更新日期：2016-06-17 00:00:00
abstract：:Metallic glasses are disordered materials that offer the unique ability to perform thermoplastic forming operations at low thermal budget while preserving excellent mechanical properties such as high strength, large elastic strain limits, and wear resistance owing to the metallic nature of bonding and lack of internal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19530
更新日期：2016-01-20 00:00:00
abstract：:The pathophysiology of diabetic nephropathy (DN) in type 2 diabetes (T2D) patients is minimally understood. We compared untargeted high-resolution accurate mass (HRAM) orbitrap-based plasma metabolomic profiles of 31 T2D-DN (with estimated glomerular filtration rate ≤80 mL/min/1.73 m2), 29 T2D and 30 normal glucose to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54584-2
更新日期：2019-12-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74584-x
更新日期：2020-10-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2019-11-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00456
更新日期：2012-01-01 00:00:00
abstract：:Detection of copy number variations (CNVs) is a first-tier clinical diagnostic test for children with neurodevelopmental disorders (NDD), which reveals the genetic cause of the disorder in more than 20%. These are mostly known microdeletion/microduplication syndromes, but variants of unknown clinical significance (VOU...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27824-0
更新日期：2018-06-21 00:00:00
abstract：:Multi-principle element alloys have enormous potential, but their exploration suffers from the tremendously large range of configurations. In the last decade such alloys have been designed with a focus on random solid solutions. Here we apply an experimentally verified, combined thermodynamic and first-principles desi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02385-w
更新日期：2017-05-19 00:00:00
abstract：:The insect vector borne bacterium Xylella fastidiosa was first detected in olive trees in Southern Italy in 2013, and identified as the main culprit behind the 'olive quick decline syndrome'. Since then, the disease has spread rapidly through Italy's main olive oil producing region. The epidemiology of the outbreak is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00077-z
更新日期：2017-03-06 00:00:00
abstract：:The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46177
更新日期：2017-04-11 00:00:00
abstract：:The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11784
更新日期：2015-07-06 00:00:00
abstract：:Therapies that target the signal transduction and metabolic pathways of cancer stem cells (CSCs) are innovative strategies to effectively reduce the recurrence and significantly improve the outcome of glioblastoma multiforme (GBM). CSCs exhibit an increased rate of glycolysis, thus rendering them intrinsically more se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15556
更新日期：2015-10-23 00:00:00
abstract：:The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69774-6
更新日期：2020-07-30 00:00:00
