Abstract：
:The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) patients and healthy subjects, and we evaluated the association between CAD MDM profile and in vivo coronary plaque characteristics assessed by optical coherence tomography (OCT). At morphological analysis, MDMs of CAD patients had a higher prevalence of round than spindle cells, whereas in healthy subjects the prevalence of the two morphotypes was similar. Compared to healthy subjects, MDMs of CAD patients had reduced efferocytosis, lower transglutaminase-2, CD206 and CD163 receptor levels, and higher tissue factor (TF) levels. At OCT, patients with a higher prevalence of round MDMs showed more frequently a lipid-rich plaque, a thin-cap fibroatheroma, a greater intra-plaque macrophage accumulation, and a ruptured plaque. The MDM efferocytosis correlated with minimal lumen area, and TF levels in MDMs correlated with the presence of ruptured plaque. MDMs obtained from CAD patients are characterized by a morpho-phenotypic heterogeneity with a prevalence of round cells, showing pro-inflammatory and pro-thrombotic properties. The MDM profile allows identifying CAD patients at high risk.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Eligini S,Cosentino N,Fiorelli S,Fabbiocchi F,Niccoli G,Refaat H,Camera M,Calligaris G,De Martini S,Bonomi A,Veglia F,Fracassi F,Crea F,Marenzi G,Tremoli Edoi
10.1038/s41598-019-44847-3subject
Has Abstractpub_date
2019-06-18 00:00:00pages
8680issue
1issn
2045-2322pii
10.1038/s41598-019-44847-3journal_volume
9pub_type
杂志文章abstract：:Endoconidiophora resinifera (=Ceratocystis resinifera) is a blue-stain fungus that occurs on conifers. The data showed that the Endoconidiophora resinifera mitochondrial genome is one of the largest mitochondrial genomes (>220 kb) so far reported among members of the Ascomycota. An exceptional large number of introns ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35926-y
更新日期：2018-12-04 00:00:00
abstract：:Most studies on buoyant microplastics in the marine environment rely on sea surface sampling. Consequently, microplastic amounts can be underestimated, as turbulence leads to vertical mixing. Models that correct for vertical mixing are based on limited data. In this study we report measurements of the depth profile of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33882
更新日期：2016-10-10 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep25577. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46944
更新日期：2018-02-16 00:00:00
abstract：:Aquaporins (AQPs) are a ubiquitous family of transmembrane water channel proteins. A subgroup of AQP water channels also facilitates transmembrane diffusion of small, polar solutes. A constriction within the pore, the aromatic/arginine (ar/R) selectivity filter, is thought to control solute permeability: previous stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56814-z
更新日期：2019-12-30 00:00:00
abstract：:Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40653-z
更新日期：2019-03-08 00:00:00
abstract：:In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43858
更新日期：2017-03-06 00:00:00
abstract：:In recent pioneer experiment, a strong spin-orbit coupling, with equal Rashba and Dresselhaus strengths, has been created in a trapped Bose-Einstein condensate. Moreover, many exotic superfluid phenomena induced by this strong spin-orbit coupling have been predicted. In this report, we show that this novel spin-orbit ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03166
更新日期：2013-11-07 00:00:00
abstract：:The removal of macroalgal biomass is critical to the health of coral reef ecosystems. Previous studies on relatively intact reefs with diverse and abundant fish communities have quantified rapid removal of macroalgae by herbivorous fishes, yet how these findings relate to degraded reef systems where fish diversity and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08873-3
更新日期：2017-08-21 00:00:00
abstract：:This paper investigates the effects of temperature on an InGaP (GaInP) 55Fe X-ray photovoltaic cell prototype for a radioisotope microbattery (also called a nuclear microbattery). An In0.5Ga0.5P p-i-n (5 μm i-layer) mesa photodiode was illuminated by a standard 206 MBq 55Fe radioisotope X-ray source and characterised ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05181-8
更新日期：2017-07-10 00:00:00
abstract：:Reperfusion alters post-myocardial infarction (MI) healing; however, very few systematic studies report the early molecular changes following ischemia/reperfusion (I/R). Alterations in the remote myocardium have also been neglected, disregarding its contribution to post-MI heart failure (HF) development. This study ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11985-5
更新日期：2017-09-27 00:00:00
abstract：:The Na+;HCO3- co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncation of the full NBCn1 C-term...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25059-7
更新日期：2018-05-09 00:00:00
abstract：:Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08666
更新日期：2015-03-02 00:00:00
abstract：:The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78160-1
更新日期：2020-12-04 00:00:00
abstract：:Diatoms are known for their intricate, silicified cell walls (frustules). Silica polymerization occurs in a compartment called the silica deposition vesicle (SDV) and it was proposed that the cytoskeleton influences silica patterning through the SDV membrane (silicalemma) via interactions with transmembrane proteins. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13613-8
更新日期：2017-10-18 00:00:00
abstract：:Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32685-8
更新日期：2018-09-26 00:00:00
abstract：:Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02560-z
更新日期：2017-06-01 00:00:00
abstract：:The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70389-0
更新日期：2020-08-26 00:00:00
abstract：:Secondhand smoke (SHS) has been associated with a variety of adverse health outcomes in nonsmokers, including emphysema (a chronic obstructive pulmonary disease). One way to detect SHS exposure is to measure the concentration of cotinine, the primary metabolite of nicotine, in bodily fluids. We have developed a method...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03864
更新日期：2014-01-27 00:00:00
abstract：:Arbuscular mycorrhizal fungi (AMF) can be beneficial for improving restoration of radioactive-cesium (137Cs)-contaminated soils through soil remediation. However, there has been no information on species diversity and the composition of AMF communities in 137Cs-contaminated soil after the Fukushima-Daiichi Nuclear Pow...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44665-7
更新日期：2019-06-03 00:00:00
abstract：:Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12703-x
更新日期：2017-10-05 00:00:00
abstract：:Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses CCR5 protein as a co-receptor. Recently, the crystal structure of CCR5-bound complex with an approved anti-retroviral drug (maroviroc) was r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13180
更新日期：2015-08-24 00:00:00
abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75062-0
更新日期：2020-10-26 00:00:00
abstract：:The aim of this study was to analyse postoperative haemorrhage (POH) after a total thyroidectomy and explore the possible risk factors. Records of patients receiving a total thyroidectomy were reviewed and analysed for risk factors of POH. From the 2,678 patients in this study, a total of 39 patients had POH, represen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07334-1
更新日期：2017-08-01 00:00:00
abstract：:Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58126-z
更新日期：2020-03-12 00:00:00
abstract：:The association of visual impairment and depression has been investigated in several studies based on a cross-sectional design, which cannot delineate temporal relationships. In the present study, we evaluated the influence of visual impairment on depression in all age groups using a longitudinal database of a nationa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20374-5
更新日期：2018-02-01 00:00:00
abstract：:Cerebral malaria (CM), a complication of malaria infection, is the cause of the majority of malaria-associated deaths in African children. The standard clinical case definition for CM misclassifies ~25% of patients, but when malarial retinopathy (MR) is added to the clinical case definition, the specificity improves f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42703
更新日期：2017-02-15 00:00:00
abstract：:Forest conservation includes stemming deforestation as well as preserving its vegetation condition. Traditional Protected Area (PA) effectiveness evaluations have assessed changes in forest extent but have mostly ignored vegetation condition. Tiger Reserves (TRs) are India's PAs with highest protection and management ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51118-8
更新日期：2019-10-18 00:00:00
abstract：:The widespread use of electric light and electronic devices has resulted in an excessive exposure to light during the late-evening and at night. This late light exposure acutely suppresses melatonin and sleepiness and delays the circadian clock. Here we investigate whether the acute effects of late-evening light expos...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-52352-w
更新日期：2019-11-05 00:00:00
abstract：:We present a formulation of electromagnetic spin-orbit coupling in magneto-optic media, and propose an alternative source of spin-orbit coupling to non-paraxial optics vortices. Our treatment puts forth a formulation of nonreciprocal transverse-spin angular-momentum-density shifts for evanescent waves in magneto-optic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39972
更新日期：2017-01-06 00:00:00
abstract：:The formation of Pb, Zn, and Cu carboxylates (soaps) has caused visible deterioration in hundreds of oil paintings dating from the 15th century to the present. Through transport phenomena not yet understood, free fatty acids in the oil binding medium migrate through the paint and react with pigments containing heavy m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11525-1
更新日期：2017-09-14 00:00:00
