Abstract：
:Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data from 178 lung SCC specimens (containing tumor and tumor-associated cells) and analyzed the correlation between SOX2 and previously-reported SOX2-controlled genes in lung SCC. In addition, we used another RNA-seq dataset from 105 non-small cell lung cancer cell lines (NSCLC; including 4 lung SCC cell lines) and again analyzed the correlation between SOX2 and the reported SOX2-controlled genes in the NSCLC cell lines (no tumor-associated cells). We combined the two analyses and identified genes commonly correlated with SOX2 in both datasets. Among the 99 genes reported as SOX2 downstream and/or correlated genes, we found 4 negatively-correlated (e.g., CDKN1A) and 11 positively-correlated genes with SOX2. We used biological studies to demonstrate that CDKN1A was suppressed by SOX2 in lung SCC cells. G1 cell cycle arrest induced by SOX2 siRNA was rescued by CDKN1A siRNA. These results indicate that the tumorigenic effect of SOX2 in lung SCC cells is mediated in part by suppression of CDKN1A.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fukazawa T,Guo M,Ishida N,Yamatsuji T,Takaoka M,Yokota E,Haisa M,Miyake N,Ikeda T,Okui T,Takigawa N,Maeda Y,Naomoto Ydoi
10.1038/srep20113subject
Has Abstractpub_date
2016-02-05 00:00:00pages
20113issn
2045-2322pii
srep20113journal_volume
6pub_type
杂志文章abstract：:We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid chromatography (OTLC) separation column functionalized with C18-groups, for separating a wide range of molecules (from small metabolites to int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37507
更新日期：2016-11-29 00:00:00
abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17777-1
更新日期：2017-12-11 00:00:00
abstract：:Our previous studies have shown that sulbactam can play a neuroprotection role in hippocampal neurons by upregulating the expression and function of glial glutamate transporter-1 (GLT-1) during ischemic insult. Here, using rat global cerebral ischemia model, we studied in vivo the role of p38 mitogen-activated protein...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77583-0
更新日期：2020-11-26 00:00:00
abstract：:The beta rhythm (15-30 Hz) is a prominent signal of sensorimotor cortical activity. This rhythm is not sustained but occurs non-rhythmically as brief events of a few (1-2) oscillatory cycles. Recent work on the relationship between these events and sensorimotor performance suggests that they are the biologically relev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54706-w
更新日期：2019-12-04 00:00:00
abstract：:miR1444s are functionally significant miRNAs targeting polyphenol oxidase (PPO) genes for cleavage. MIR1444 genes were reported only in Populus trichocarpa. Through the computational analysis of 215 RNA-seq data, four whole genome sequences of Salicaceae species and deep sequencing of six P. trichocarpa small RNA libr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39740
更新日期：2017-01-10 00:00:00
abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26533-y
更新日期：2018-05-30 00:00:00
abstract：:This study is the first report on the preparation of mesoporous carbon/silica (MCS) nanocomposites with tunable mesoporosity and hydrophobicity using natural rubber (NR) as a renewable and cheap carbon source. A series of mesoporous nanocomposites based on NR and hexagonal mesoporous silica (HMS) were prepared via an ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69963-3
更新日期：2020-07-31 00:00:00
abstract：:Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well as pathophysiological states could induce changes in macrophage m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42180-3
更新日期：2019-04-05 00:00:00
abstract：:The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44332
更新日期：2017-03-09 00:00:00
abstract：:Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09365-0
更新日期：2017-08-18 00:00:00
abstract：:The microtubule cytoskeleton is composed of α-tubulin and β-tubulin heterodimers, and it serves to regulate the shape, motility, and division of a cell. Post-translational modifications including acetylation are closely associated with the functional aspects of the microtubule, involving in a number of pathological di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27775
更新日期：2016-06-08 00:00:00
abstract：:The extraction of renewable energy resources particularly from earth abundant materials has always been a matter of significance in industrial products. Herein, we report a novel simultaneous extraction of nano-silicon with activated carbons (nano-Si@ACs) from rice husk (RH) by chemical activation method. As-extracted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39314
更新日期：2016-12-21 00:00:00
abstract：:EEG is known to contain considerable inter-trial and inter-subject variability, which poses a challenge in any group-level EEG analyses. A true experimental effect must be reproducible even with variabilities in trials, sessions, and subjects. Extracting components that are reproducible across trials and subjects bene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56962-2
更新日期：2020-01-09 00:00:00
abstract：:The present study was aimed at evaluating the fluorescence property, sporicidal potency against Bacillus and Clostridium endospores, and surface disinfecting ability of biogenic nano silver. The nano silver was synthesized using an actinobacterial cell-filtrate. The fluorescence property as well as imaging facilitator...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34058
更新日期：2016-09-26 00:00:00
abstract：:The transfer of the flexor hallucis longus tendon or flexor digitorum longus tendon is frequently used for the treatment of posterior tibial tendon insufficiency or chronic Achilles tendinopathy. According to several anatomical studies, harvesting the flexor hallucis longus (FHL) tendon may cause nerve injury. Sixty-e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13742-0
更新日期：2017-10-27 00:00:00
abstract：:This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78965-0
更新日期：2020-12-14 00:00:00
abstract：:With the aim to capture and subsequent selective trapping of CO2, a nanocomposite has been developed through selective modification of the outer surface of the halloysite nanotubes (HNTs) with an organosilane to make the nanocomposite a novel solid-phase adsorbent to adsorb CO2 from the atmosphere at standard ambient ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08711
更新日期：2015-03-04 00:00:00
abstract：:The absorption spectra in array of Ge, Al and Ge/Al-shell nanoparticles immersed in alumina (Al2O3) matrix is calculated in framework of ab initio macroscopic dielectric model. It is demonstrated that absorption is strongly enhanced when germanium nanospheres are encapsulated by Al-shell. Two absorption peaks, appeari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56673-8
更新日期：2020-01-09 00:00:00
abstract：:Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73308-5
更新日期：2020-10-06 00:00:00
abstract：:Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mappin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45020
更新日期：2017-03-22 00:00:00
abstract：:Here, we report large, near-daily oscillations of near-bottom temperatures, with ranges of up to 11.5 °C at depths of 30-60 m in September 2011 around the Saint Pierre and Miquelon archipelago (south-eastern Canada). These oscillations were detected on velocity and temperature profiles from moorings in Miquelon Bay an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31857-w
更新日期：2018-09-17 00:00:00
abstract：:A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32167
更新日期：2016-08-30 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58622-2
更新日期：2020-01-28 00:00:00
abstract：:Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13357-5
更新日期：2017-10-13 00:00:00
abstract：:The access and recycling of the base cations are essential processes for the long-lasting functioning of forest ecosystems. While the role of soil bacterial communities has been demonstrated in mineral weathering and tree nutrition, our understanding of the link between the availability of base cations and the functio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50730-y
更新日期：2019-10-07 00:00:00
abstract：:The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04206
更新日期：2014-02-26 00:00:00
abstract：:The neuropathology of Parkinson's disease (PD) involves the frontal-subcortical circuit, an area responsible for processing affective theory of mind (ToM). Patients with PD are expected to experience deficits in the affective ToM. This study aims to investigate whether the ability to infer emotion in others is affecte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33988-6
更新日期：2018-10-30 00:00:00
abstract：:Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02223-z
更新日期：2017-05-17 00:00:00
abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28529-0
更新日期：2018-07-10 00:00:00
abstract：:The tibial tuberosity-trochlear groove (TT-TG) distance is a radiographic measurement that is used to quantify malalignment of the patellofemoral joint (PFJ) in cross-sectional imaging. There is an ongoing debate about the impact of the TT-TG-distance on lateral patellar instability and the initiating of cartilage deg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72299-7
更新日期：2020-09-18 00:00:00
