Abstract:
:Data on post stroke outcomes in developing countries are scarce due to uncoordinated healthcare delivery systems. In Malaysia, the national stroke clinical practice guideline does not address transfer of care and longer term post stroke care beyond tertiary care. Hence, post stroke care delivery may be delivered at either tertiary or primary care facilities. This study aimed at describing patients' characteristics and outcomes of post stroke care delivered by the primary care teams at public primary care healthcentres across Peninsular Malaysia. Multi staged sampling was done to select public primary care health centres to recruit post stroke patients. At each health centre, convenience sampling was done to recruit adult patients (≥18 years) who received post stroke care between July-December 2012. Baseline measurements were recorded at recruitment and retrospective medical record review was done simultaneously, for details on medical and / or rehabilitation treatment at health centre. Changes in the measurements for post stroke care were compared using paired t-tests and Wilcoxon Rank test where appropriate. Total of 151 patients were recruited from ten public primary care healthcentres. The mean age at stroke presentation was 55.8 ± 9.8 years. Median duration of follow up was 2.3 (IQR 5.1) years. Majority co-resided with a relative (80.8%), and a family member was primary caregiver (75.%). Eleven percent were current smokers. Almost 71.0% of patients achieved BP ≤ 140/90 mmHg. Only 68.9% of the patients had been referred for neurorehabilitation. Percentage of recorded data was highest for blood pressure (88.1%) while lowest was HbA1c (43.0%). For clinical outcomes, systolic and diastolic blood pressure, triglyceride level and calculated GFR (eGFR) showed statistically significant changes during follow up (p < 0.05). Post stroke care at public primary care healthcentres showed benefits in stroke risk factors control (i.e. hypertension and dyslipidaemia) but deterioration in renal function. A more structured coordination is needed to optimise post stroke care beyond acute phase management for patients who reside at home in the community.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Abdul Aziz AF,Ali MF,Yusof MF,Che' Man Z,Sulong S,Aljunid SMdoi
10.1038/s41598-018-36154-0subject
Has Abstractpub_date
2018-12-19 00:00:00pages
17965issue
1issn
2045-2322pii
10.1038/s41598-018-36154-0journal_volume
8pub_type
杂志文章abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-26061-9
更新日期:2018-05-15 00:00:00
abstract::Total Grain-Size Distribution (TGSD) of tephra deposits is key to the characterization of explosive volcanism, plume-dispersal modeling, and magmatic fragmentation studies. Nonetheless, various aspects that includes deposit exposure and data fitting make its determination extremely complex and affect its representativ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46125-8
更新日期:2019-07-10 00:00:00
abstract::Platelet activation is an important event involved in the pathophysiological processes of the coagulation system. Clinical evidence has shown that platelets undergo distinctive pathological processes during sepsis. Unfortunately, how platelets physiologically respond to inflammation or sepsis is not well understood. I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23653
更新日期:2016-03-29 00:00:00
abstract::Smart nanoparticles (NPs) that respond to external and internal stimulations have been developing to achieve optimal drug release in tumour. However, applying these smart NPs to attain high antitumour performance is hampered by limited drug carriers and inefficient spatiotemporal control. Here we report a noninvasive ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14258
更新日期:2015-09-24 00:00:00
abstract::Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69073-0
更新日期:2020-07-22 00:00:00
abstract::Catharanthus roseus is a commercial source for anti-cancer terpenoid indole alkaloids (TIAs: vincristine and vinblastine). Inherent levels of these TIAs are very low, hence research studies need to focus on enhancing their levels in planta. Since primary metabolism provides precursors for specialized-metabolism, eleva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33415-w
更新日期:2018-10-10 00:00:00
abstract::The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30431-8
更新日期:2018-08-17 00:00:00
abstract::For the past 30 years, oocytes from Xenopus laevis have been extensively used to express and characterise ion channels in an easily controlled environment. Here we report the first use of oocytes from the closely related species Xenopus borealis as an alternative expression system for neuronal ion channels. Using the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14763
更新日期:2015-10-06 00:00:00
abstract::The PRL phosphatases are oncogenic when overexpressed but their in vivo biological function is less well understood. Previous gene deletion study revealed a role for PRL2 in spermatogenesis. We report here the first knockout mice lacking PRL1, the most related homolog of PRL2. We found that loss of PRL1 does not affec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34211
更新日期:2016-09-26 00:00:00
abstract::We examined whether it is possible to identify individual subjects on the basis of brain anatomical features. For this, we analyzed a dataset comprising 191 subjects who were scanned three times over a period of two years. Based on FreeSurfer routines, we generated three datasets covering 148 anatomical regions (corti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23696-6
更新日期:2018-04-04 00:00:00
abstract::The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16099
更新日期:2015-11-05 00:00:00
abstract::Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer components cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood. From X-ray scattering, neutron scattering and spectroscopic data, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79676-2
更新日期:2021-01-11 00:00:00
abstract::Formamidinium lead iodide (CH(NH2)2PbI3, FAPI) thin films have been deposited on glass substrates at 150 °C using ambient pressure aerosol assisted chemical vapour deposition (AACVD). The films have been analysed by a range of techniques including powder X-ray diffraction (pXRD), scanning electron microscopy (SEM), en...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79291-1
更新日期:2020-12-17 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42642
更新日期:2017-02-14 00:00:00
abstract::High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42863
更新日期:2017-02-17 00:00:00
abstract::Marine plant communities such as kelp forests produce significant amounts of detritus, most of which is exported to areas where it can constitute an important trophic subsidy or potentially be sequestered in marine sediments. Knowing the vertical transport speed of detrital particles is critical to understanding the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34721-z
更新日期:2018-11-21 00:00:00
abstract::Planktonic foraminifera (PF) life cycles are highly sensitive to marine conditions, which are evolving rapidly due to anthropogenic climate change. Even though PF shells in the sedimentary record serve as prominent proxies of past ocean conditions, very little is still known about their life cycles, particularly in ol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74342-z
更新日期:2020-10-15 00:00:00
abstract::The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) offers interactive visualization and exploration of TCGA genomic, phenotypic, and clinical data, as produced by the Cancer Genome Atlas Research Network. Researchers can explore the impact of genomic alterations on phenotypes by visualizing gene and pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02652
更新日期:2013-10-02 00:00:00
abstract::PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28890
更新日期:2016-07-04 00:00:00
abstract::The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple tissues where its function is critical in establishing and maintaining epithelial integrity. Here, we analysed awd gene function in Drosophila epithelial cells using transgene-mediated RNA i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17217-0
更新日期:2017-12-04 00:00:00
abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31198
更新日期:2016-08-09 00:00:00
abstract::Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the associatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16196-6
更新日期:2017-11-21 00:00:00
abstract::Sense of touch is a major part of man's communication with their environment. Artificial skins can help robots to have the same sense of touch, especially for their social interactions. This paper presents a pressure mapping sensing using piezo-resistive fabric to represent aspects of the sense of touch. In past few y...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45484-6
更新日期:2019-06-20 00:00:00
abstract::We constructed Antarctic ice velocity maps from Landsat 8 images for the years 2014 and 2015 at a high spatial resolution (100 m). These maps were assembled from 10,690 scenes of displacement vectors inferred from more than 10,000 optical images acquired from December 2013 through March 2016. We estimated the mass dis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22765-0
更新日期:2018-03-14 00:00:00
abstract::The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling. We utilized functional magnetic resonance imaging on NaV1.8-deficient (NaV1.8-/-) compared with wildtype (WT) mice to identify brain struct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00524-x
更新日期:2017-04-03 00:00:00
abstract::Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quantitative analysis into the locomotor abilities of a stem-archosaur app...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70175-y
更新日期:2020-09-21 00:00:00
abstract::MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03148-3
更新日期:2017-06-06 00:00:00
abstract::Cohesins are vital for chromosome organisation during meiosis and mitosis. In addition to the important function in sister chromatid cohesion, these complexes play key roles in meiotic recombination, DSB repair, homologous chromosome pairing and segregation. Egg-laying mammals (monotremes) feature an unusually complex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04560-5
更新日期:2017-06-26 00:00:00
abstract::Oryza coarctata (KKLL; 2n = 4x = 48, 665 Mb) also known as Porteresia coarctata is an extreme halophyte species of genus Oryza. Using Illumina and Nanopore reads, we achieved the assembled genome size of 569.9 Mb, accounting 85.69% of the estimated genome size with N50 of 1.85 Mb and 19.89% repetitive region. We also ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31518-y
更新日期:2018-09-12 00:00:00
abstract::Temporal-difference (TD) learning models afford the neuroscientist a theory-driven roadmap in the quest for the neural mechanisms of reinforcement learning. The application of these models to understanding the role of phasic midbrain dopaminergic responses in reward prediction learning constitutes one of the greatest ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42244-4
更新日期:2019-04-12 00:00:00