Micelle-stabilized Olfactory Receptors for a Bioelectronic Nose Detecting Butter Flavors in Real Fermented Alcoholic Beverages.

abstract：:Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...

journal_title：Scientific reports

authors： Boulding T,McCuaig RD,Tan A,Hardy K,Wu F,Dunn J,Kalimutho M,Sutton CR,Forwood JK,Bert AG,Goodall GJ,Malik L,Yip D,Dahlstrom JE,Zafar A,Khanna KK,Rao S

更新日期：2018-01-08 00:00:00

abstract：:Photoreceptor cell death is the ultimate process underlying many retinal diseases, including retinal detachment (RD). Both autophagy and inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), participate in photoreceptor cell death after RD. In this study, we examined whether TNF-α inhibition would impact ...

journal_title：Scientific reports

authors： Xie J,Zhu R,Peng Y,Gao W,Du J,Zhao L,Chi Y,Yang L

更新日期：2017-12-07 00:00:00

abstract：:Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and func...

journal_title：Scientific reports

authors： Katchalski T,Case T,Kim KY,Ramachandra R,Bushong EA,Deerinck TJ,Haberl MG,Mackey MR,Peltier S,Castillon GA,Fujikawa N,Lawrence AR,Ellisman MH

更新日期：2018-05-15 00:00:00

abstract：:By means of extensive ab initio calculations, a new two-dimensional (2D) atomic material tin selenide monolayer (coined as tinselenidene) is predicted to be a semiconductor with an indirect gap (~1.45 eV) and a high hole mobility (of order 10000 cm(2)V(-1)S(-1)), and will bear an indirect-direct gap transition under a...

journal_title：Scientific reports

authors： Zhang LC,Qin G,Fang WZ,Cui HJ,Zheng QR,Yan QB,Su G

更新日期：2016-02-01 00:00:00

abstract：:Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes. Here, we examined the role of lysine side chain length in the catalytic activity of human KATs by incorporating shorter and longer lysine analogs into synthetic...

journal_title：Scientific reports

authors： Proietti G,Wang Y,Rainone G,Mecinović J

更新日期：2020-08-03 00:00:00

abstract：:The pathways of protein post-translational modifications (PTMs) have been shown to play particularly important roles for almost any biological process. Identification of PTM substrates along with information on the exact sites is fundamental for fully understanding or controlling biological processes. Alternative comp...

journal_title：Scientific reports

authors： Chen X,Shi SP,Xu HD,Suo SB,Qiu JD

更新日期：2016-05-13 00:00:00

abstract：:Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...

journal_title：Scientific reports

authors： Scalzone A,Ferreira AM,Tonda-Turo C,Ciardelli G,Dalgarno K,Gentile P

更新日期：2019-10-10 00:00:00

abstract：:Hookworms are one of the most prevalent and important parasites, infecting ~500 million people worldwide. Hookworm disease is among the leading causes of iron-deficiency anemia in the developing world and is associated with significant growth stunting and malnutrition. In humans, hookworms appear to impair memory and ...

journal_title：Scientific reports

authors： Pan SC,Ward DV,Yin Y,Hu Y,Elfawal MA,Clark RE,Aroian RV

更新日期：2019-05-27 00:00:00

abstract：:Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize that phosphate deficiency altered the circadian cycle in peripheral tissues. Analysis of the expression of the central clock g...

journal_title：Scientific reports

authors： Noguchi T,Hussein AI,Horowitz N,Carroll D,Gower AC,Demissie S,Gerstenfeld LC

更新日期：2018-09-13 00:00:00

abstract：:In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages retain any persistent memory of past polarization states which may then impact their future repolarization to new states. Here, we perform deep transcriptomic p...

journal_title：Scientific reports

authors： Liu SX,Gustafson HH,Jackson DL,Pun SH,Trapnell C

更新日期：2020-07-23 00:00:00

abstract：:Oxide heterointerfaces are ideal for investigating strong correlation effects to electron transport, relevant for oxide-electronics. Using hot-electrons, we probe electron transport perpendicular to the La₀.₇Sr₀.₃MnO₃ (LSMO)- Nb-doped SrTiO₃ (Nb:STO) interface and find the characteristic hot-electron attenuation lengt...

journal_title：Scientific reports

authors： Rana KG,Yajima T,Parui S,Kemper AF,Devereaux TP,Hikita Y,Hwang HY,Banerjee T

更新日期：2013-01-01 00:00:00

abstract：:Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...

journal_title：Scientific reports

authors： Seppa K,Toots M,Reimets R,Jagomäe T,Koppel T,Pallase M,Hasselholt S,Krogsbæk Mikkelsen M,Randel Nyengaard J,Vasar E,Terasmaa A,Plaas M

更新日期：2019-10-31 00:00:00

abstract：:Gold is a noble metal typically stable as a solid in a face-centered cubic (FCC) structure under ambient conditions; however, under particular circumstances aberrant allotropes have been synthesized. In this work, we document the phase transformation of 25 nm thick nanocrystalline (NC) free-standing gold thin-film via...

journal_title：Scientific reports

authors： Suri PK,Nathaniel JE 2nd,Li N,Baldwin JK,Wang Y,Hattar K,Taheri ML

更新日期：2020-10-20 00:00:00

abstract：:Persistent shortage and heterogeneous quality of liver grafts encourages the optimization of donor-recipient matching in liver transplantation (LT). We explored whether or not there was a survival benefit (SB) of LT according to the quality of grafts assessed by the Donor Quality Index (DQI) and recipients' disease se...

journal_title：Scientific reports

authors： Winter A,Féray C,Antoine C,Azoulay D,Daurès JP,Landais P

更新日期：2020-03-05 00:00:00

abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...

journal_title：Scientific reports

authors： Jia X,Zhao Y,Wang W,He Y

更新日期：2015-09-23 00:00:00

abstract：:Because of the lack of cell wall, Micoplasma species require a fine control of membrane fluidity and integrity. mg517 is an essential gene of Mycoplasma genitalium responsible for the biosynthesis of membrane glycoglycerolipids. It encodes for a unique glycosyltransferase (MG517) with processive activity, transferring...

journal_title：Scientific reports

authors： Romero-García J,Biarnés X,Planas A

更新日期：2019-05-08 00:00:00

abstract：:Seagrass meadows are among the four most productive marine ecosystems in the world. Zostera japonica (Z. japonica) is the most widely distributed species of seagrass in China. However, there is no reference genome or transcriptome available for Z. japonica, impeding progress in functional genomic and molecular ecology...

journal_title：Scientific reports

authors： Chen S,Qiu G,Yang M

更新日期：2019-10-10 00:00:00

abstract：:Burley tobacco (Nicotiana Tabacum) is a chlorophyll-deficiency mutant. Nitrate is one precursor of tobacco-specific nitrosamines (TSNAs) and is largely accumulated in burley tobacco. To decrease nitrate accumulation in burley tobacco, glycerol, a polyhydric alcohol compound and physiological regulating material, was s...

journal_title：Scientific reports

authors： Li Y,Chang D,Yang H,Wang J,Shi H

更新日期：2018-09-05 00:00:00

abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

journal_title：Scientific reports

authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

更新日期：2016-04-11 00:00:00

abstract：:TRPA1 is a Ca2+-permeable ion channel involved in many sensory disorders such as pain, itch and neuropathy. Notably, the function of TRPA1 depends on Ca2+, with low Ca2+ potentiating and high Ca2+ inactivating TRPA1. However, it remains unknown how Ca2+ exerts such contrasting effects. Here, we show that Ca2+ regulate...

journal_title：Scientific reports

authors： Hasan R,Leeson-Payne AT,Jaggar JH,Zhang X

更新日期：2017-03-23 00:00:00

abstract：:The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel was developed to deliver BMSCs, which improve the chronic inflammation microenvironments ...

journal_title：Scientific reports

authors： Chen S,Shi J,Zhang M,Chen Y,Wang X,Zhang L,Tian Z,Yan Y,Li Q,Zhong W,Xing M,Zhang L,Zhang L

更新日期：2015-12-08 00:00:00

abstract：:Nitrogen-doped graphene oxides (GO:Nx) were synthesized by a partial reduction of graphene oxide (GO) using urea [CO(NH2)2]. Their electronic/bonding structures were investigated using X-ray absorption near-edge structure (XANES), valence-band photoemission spectroscopy (VB-PES), X-ray emission spectroscopy (XES) and ...

journal_title：Scientific reports

authors： Chuang CH,Ray SC,Mazumder D,Sharma S,Ganguly A,Papakonstantinou P,Chiou JW,Tsai HM,Shiu HW,Chen CH,Lin HJ,Guo J,Pong WF

更新日期：2017-02-10 00:00:00

abstract：:The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2 (GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to display a function, particularly in anxiety, depression, and appetite regulation, the further determination of its function would benefit from a more st...

journal_title：Scientific reports

authors： Reyes-Alcaraz A,Lee YN,Son GH,Kim NH,Kim DK,Yun S,Kim DH,Hwang JI,Seong JY

更新日期：2016-02-24 00:00:00

abstract：:In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...

journal_title：Scientific reports

authors： Zhang L,Zhang J,Ye Z,Manevich Y,Townsend DM,Marshall DT,Tew KD

更新日期：2019-09-24 00:00:00

abstract：:A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, semi-conducting behavior, catalytic activity and a remarkably good chemical stability, makes it an ideal material for a wide range of technological...

journal_title：Scientific reports

authors： Mondal S,Bykova E,Dey S,Ali SI,Dubrovinskaia N,Dubrovinsky L,Parakhonskiy G,van Smaalen S

更新日期：2016-01-18 00:00:00

abstract：:G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...

journal_title：Scientific reports

authors： Pathak RR,Mandal VK,Jangam AP,Sharma N,Madan B,Jaiswal DK,Raghuram N

更新日期：2021-01-27 00:00:00

abstract：:Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell char...

journal_title：Scientific reports

authors： Park K,Kim JY,Lee C,Jeon S,Lim G,Kim C

更新日期：2017-10-17 00:00:00

abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...

journal_title：Scientific reports

authors： Long L,Xu L,Xiao Z,Hu S,Luo R,Wang H,Lu X,Xu Z,Yao X,Zhou L,Long H,Gong J,Song Y,Zhao L,Luo K,Zhang M,Feng L,Yang L,Sheng X,Fan X,Xiao B

更新日期：2016-03-22 00:00:00

abstract：:Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical induction of status epilepticus (SE). ...

journal_title：Scientific reports

authors： Zhu H,Zhao Y,Wu H,Jiang N,Wang Z,Lin W,Jin J,Ji Y

更新日期：2016-12-01 00:00:00

abstract：:The oral microbiota change dramatically with each part of the oral cavity, even within the same mouth. Nevertheless, the microbiota associated with peri-implantitis and periodontitis have been considered the same. To improve our knowledge of the different communities of complex oral microbiota, we compared the microbi...

journal_title：Scientific reports

authors： Maruyama N,Maruyama F,Takeuchi Y,Aikawa C,Izumi Y,Nakagawa I

更新日期：2014-10-13 00:00:00